Hookworm infectious disease
diseaseOn this page
Also known as BunostomiasesBunostomiasishookworm infectioninfection, hookworminfections, hookworm
Summary
Hookworm infectious disease (MONDO:0005799) is a disease and 33 clinical trials. Top therapeutic interventions include mebendazole, albendazole, and moxidectin. A subtype of infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 33
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | hookworm infectious disease |
| Mondo ID | MONDO:0005799 |
| EFO | EFO:0007314 |
| Is cancer (heuristic) | no |
Also known as: Bunostomiases · Bunostomiasis · hookworm infection · infection, hookworm · infections, hookworm
Disease family
This is a subtype of infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › hookworm infectious disease
Related subtypes (34): infective endocarditis, hirudiniasis, fungal infectious disease, infectious peritonitis, epididymitis, viral infectious disease, bacterial infectious disease, parasitic infectious disease, abscess, Ciliophora infectious disease, infectious embryofetopathy, mycetoma, infectious disorder of the nervous system, ear infection, sexually transmitted disease, puerperal infection, Acanthamoeba infectious disease, infectious myositis, infective vaginitis, skin disorder caused by infection, respiratory tract infectious disorder, nail infection, infective arthritis, digestive system infectious disorder, nosocomial infection, eye infectious disorder, prosthesis-related infectious disease, vector-borne disease, coinfection, urinary tract infection, hemorrhagic fever, protothecosis, pythiosis, infectious disease with sepsis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Albendazole, Aluminum Hydroxide, Mebendazole.
Clinical trials & evidence
Clinical trials
Clinical trials: 33.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE1 | 11 |
| PHASE2 | 7 |
| Not specified | 7 |
| PHASE3 | 4 |
| PHASE4 | 3 |
| PHASE2/PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT07145736 | PHASE4 | RECRUITING | Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases |
| NCT03261596 | PHASE4 | WITHDRAWN | Mebendazole Study Against Hookworm Infections in Children and Adolescents in Ghana |
| NCT03278431 | PHASE4 | COMPLETED | Triple Combinations Against Hookworm Infections in Lao |
| NCT06736691 | PHASE3 | ENROLLING_BY_INVITATION | Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections |
| NCT06800248 | PHASE3 | NOT_YET_RECRUITING | Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections |
| NCT04700423 | PHASE2/PHASE3 | COMPLETED | Efficacy and Safety of MOX/ALB vs. IVM/ALB Co-administration |
| NCT04726969 | PHASE3 | COMPLETED | Efficacy and Safety of MOX/ALB Co-administration |
| NCT06188715 | PHASE3 | COMPLETED | Efficacy and Safety of Moxidectin-Albendazole Co-administration in SAC |
| NCT03172975 | PHASE2 | COMPLETED | Efficacy of Na-GST-1/Alhydrogel Hookworm Vaccine Assessed by Controlled Challenge Infection |
| NCT03527745 | PHASE2 | COMPLETED | Albendazole Dose Finding and Pharmacokinetics in Children and Adults |
| NCT03995680 | PHASE2 | COMPLETED | Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm |
| NCT05017194 | PHASE2 | COMPLETED | Efficacy and Safety of Emodepside in Adults Infected With Trichuris Trichiura and Hookworm |
| NCT05538767 | PHASE2 | COMPLETED | Efficacy and Safety of Emodepside in Adolescents and Adults Infected With Hookworm |
| NCT06184399 | PHASE2 | COMPLETED | Efficacy, Safety and Acceptability of Ivermectin ODT in PSAC |
| NCT06720259 | PHASE2 | COMPLETED | Efficacy and Safety of Oxantel Pamoate in Children Infected With Trichuris Trichiura |
| NCT01940757 | PHASE1 | RECRUITING | Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae |
| NCT00120081 | PHASE1 | COMPLETED | Study of Na-ASP-2 Human Hookworm Vaccine in Healthy Adults Without Evidence of Hookworm Infection |
| NCT00473967 | PHASE1 | TERMINATED | Phase 1 Trial of Na-ASP-2 Hookworm Vaccine in Previously Infected Brazilian Adults |
| NCT01261130 | PHASE1 | COMPLETED | Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With or Without Additional Adjuvant in Brazilian Adults |
| NCT01385189 | PHASE1 | COMPLETED | Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With Different Doses of a Novel Adjuvant |
| NCT01717950 | PHASE1 | COMPLETED | Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults |
| NCT02126462 | PHASE1 | COMPLETED | Safety and Immunogenicity of Co-Administered Hookworm Vaccine Candidates Na-GST-1 and Na-APR-1 in Gabonese Adults |
| NCT02143518 | PHASE1 | COMPLETED | Safety and Immunogenicity Study of Na-GST-1 With or Without CpG |
| NCT02476773 | PHASE1 | COMPLETED | Study of Na-APR-1 (M74)/Alhydrogel® Co-administered With Na-GST-1/Alhydrogel in Brazilian Adults |
| NCT02839161 | PHASE1 | COMPLETED | Study of Co-administered Na-APR-1 (M74) and Na-GST-1 in Gabonese Children |
| NCT03373214 | PHASE1 | COMPLETED | Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults |
| NCT00207753 | Not specified | COMPLETED | Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections |
| NCT00603889 | Not specified | COMPLETED | Development of a Skin Test for the Na-ASP-2 Hookworm Antigen |
| NCT00939198 | Not specified | COMPLETED | Prevalence of Hookworm Infection and Community Preparedness for Hookworm Vaccine Trials in Endemic Areas of Brazil |
| NCT01163877 | Not specified | COMPLETED | Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma |
| NCT02262403 | Not specified | UNKNOWN | Hookworm Immune Regulation Project |
| NCT04227834 | Not specified | UNKNOWN | Soil-transmitted Helminth Reinfection Rates After Single and Repeated School Hygiene Education |
| NCT05914363 | Not specified | COMPLETED | Evaluating Impact of Improved Floors on Health |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| MEBENDAZOLE | 4 | 6 |
| ALBENDAZOLE | 4 | 5 |
| MOXIDECTIN | 4 | 3 |
| PYRANTEL | 4 | 3 |
| HEPATITIS B VIRUS HBSAG SURFACE PROTEIN ANTIGEN | 4 | 2 |
| IVERMECTIN | 4 | 2 |
| OXANTEL | 2 | 4 |
| EMODEPSIDE | 2 | 2 |
| GLA-AF | 2 | 2 |
| CHEMBL4782609 | 0 | 3 |
| CHEMBL5280985 | 0 | 3 |
| CHEMBL263291 | 0 | 2 |
| CHEMBL4082099 | 0 | 2 |
| CHEMBL4788951 | 0 | 2 |
| CHEMBL283807 | 0 | 2 |