Hyperacusis

Summary

Hyperacusis (MONDO:0043303) is a disease and 16 clinical trials. Top therapeutic interventions include rimegepant. A subtype of disorder of ear — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 16

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	hyperacusis
Mondo ID	MONDO:0043303
MeSH	D012001
ICD-10-CM	H93.23
ICD-11	652034206
NCIT	C116366
SNOMED CT	25289003
UMLS	C0034880
MedGen	20497
GARD	0027969
Is cancer (heuristic)	no

Also known as: auditory hyperesthesia · auditory Hyperesthesias · disturbance, loudness perception · disturbances, loudness perception · hyperacuses · hyperacusia · hyperacusias · hyperacusis · hyperesthesia, auditory · hyperesthesias, auditory · loudness perception disturbance · loudness perception disturbances · loudness recruitment · loudness Recruitments · low tolerance to sound · perception disturbance, loudness · perception disturbances, loudness · phonophobia · Phonophobias · recruitment, loudness

Disease family

This is a subtype of disorder of ear. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › otorhinolaryngologic disease › disorder of ear › hyperacusis

Related subtypes (5): inner ear disorder, external ear disorder, middle ear disorder, ear neoplasm, ear infection

Subtypes (1): noxacusis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 16.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	11
PHASE4	2
PHASE3	1
PHASE2/PHASE3	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00730834	PHASE4	UNKNOWN	Customized Acoustic Stimulation for Long Term Medical Benefit for the Relief of Tinnitus and Hyperacusis
NCT05207865	PHASE4	COMPLETED	Safety and Tolerability Study of Daily Dosing Rimegepant in Episodic Migraine Prevention
NCT00330850	PHASE3	COMPLETED	An Efficacy Study of a Single Dose Treatment of PRO-513 for Subjects Suffering a Migraine Attack
NCT00486577	PHASE2/PHASE3	COMPLETED	Chronic Electrical Stimulation of the Auditory Cortex for Intractable Tinnitus
NCT00890526	PHASE1	COMPLETED	Intervention for Reduced Sound Tolerance
NCT01793168	Not specified	RECRUITING	Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
NCT04705246	Not specified	NOT_YET_RECRUITING	Role of Exposure in Hyperacusis
NCT04934371	Not specified	NOT_YET_RECRUITING	Treatment of Tinnitus With Noninvasive Neuromodulation and Listening Therapy
NCT05976789	Not specified	RECRUITING	A Feasibility Study of a Novel, Fully Remote Counseling and Sound Therapy Program for Hyperacusis
NCT07527780	Not specified	RECRUITING	Prevalence of Misophonia and Hyperacusis Among Teachers
NCT01321814	Not specified	COMPLETED	Cognitive Behavioral Therapy for Hyperacusis
NCT03206996	Not specified	COMPLETED	Exposure Therapy for Auditory Sensitivity in Autism
NCT04693819	Not specified	COMPLETED	Exploratory Study on the Role of Somatic Modulation in Hyperacusis
NCT04752176	Not specified	UNKNOWN	Evaluation of the Elimination of Tinnitus and Hyperacusis by the ØREBLUE® Method
NCT06466668	Not specified	UNKNOWN	De Oorzaak: Citizen Science Project on the Impact of Environmental Noise
NCT07302373	Not specified	WITHDRAWN	Closed-loop Rehabilitation for Hyperactive Hearing

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
RIMEGEPANT	4	1