Hypereosinophilia of undetermined significance

Summary

Hypereosinophilia of undetermined significance (MONDO:0100059) is a disease. A subtype of hypereosinophilic syndrome — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	hypereosinophilia of undetermined significance
Mondo ID	MONDO:0100059
UMLS	C5666804
MedGen	1812275
GARD	0026029
Is cancer (heuristic)	no

Also known as: benign eosinophilia · HEUS

Disease family

This is a subtype of hypereosinophilic syndrome. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › syndromic disease › hypereosinophilic syndrome › hypereosinophilia of undetermined significance

Related subtypes (7): pulmonary eosinophilia, disseminated eosinophilic collagen disease, eosinophilia-myalgia syndrome, idiopathic hypereosinophilic syndrome, primary hypereosinophilic syndrome, secondary hypereosinophilic syndrome, episodic angioedema with eosinophilia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.