Hypermobility syndrome

Summary

Hypermobility syndrome (MONDO:0001798) is a disease and 16 clinical trials. A subtype of arthropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 16

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	hypermobility syndrome
Mondo ID	MONDO:0001798
DOID	DOID:13781
ICD-10-CM	M35.7
SNOMED CT	85551004
UMLS	C0152093
MedGen	508885
Is cancer (heuristic)	no

Disease family

This is a subtype of arthropathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › arthropathy › hypermobility syndrome

Related subtypes (23): transient arthropathy, synovial plica syndrome, Tietze syndrome, neurogenic arthropathy, Behcet syndrome arthropathy, ankylosis, bursitis, synovium neoplasm, hydrarthrosis, articular cartilage disorder, hemarthrosis, tenosynovitis, ganglion or cyst of synovium/tendon/bursa, spondyloarthropathy, temporomandibular joint disorder, arthritic joint disease, de Quervain disease, frozen shoulder, patellofemoral pain syndrome, secondary hypertrophic osteoarthropathy, shoulder impingement syndrome, crystal arthropathy, vertebral joint disorder

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 16.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	14
PHASE4	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07020455	PHASE4	COMPLETED	Is the Combine Prolotherapy More Effective Than the Traditional Prolotherapy in Patients With Temporomandibular Joint Hypermobility?
NCT02869373	PHASE2	COMPLETED	Spinal Stabilization Exercise Effects in Hypermobility
NCT05698446	Not specified	RECRUITING	Comparison of MBR + Suture Tape, MBR, and Anatomic Reconstruction for CLAI in GJL Cases: A Prospective Cohort Study
NCT05871216	Not specified	RECRUITING	Functional Instability in Patients Suffering From Collagen Disease and Joint Hypermobility
NCT06277401	Not specified	RECRUITING	Exercise in Patients With Hypermobile Joints and Knee Pain
NCT07044999	Not specified	NOT_YET_RECRUITING	Evaluation of Balance and Physical Performance Under Dual Task Conditions in Individuals With and Without Generalized Joint Hypermobility
NCT07294014	Not specified	RECRUITING	Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema
NCT07438873	Not specified	NOT_YET_RECRUITING	Dynamic Lycra Garments for Hip Dysplasia Feasibility Study
NCT04666896	Not specified	TERMINATED	Patient-based Care Versus Standard Care for Patients With hEDS/HSD and Multidirectional Shoulder Instability
NCT04734041	Not specified	COMPLETED	Integrative Medicine for Hypermobility Spectrum Disorder and Ehlers-Danlos Syndromes (IMforHSDandEDS)
NCT04934267	Not specified	UNKNOWN	The Effect of Joint Hypermobility Syndrome on Delayed Onset of Muscle Soreness and Recovery Time
NCT04972565	Not specified	COMPLETED	Dyspnea in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder
NCT05685199	Not specified	TERMINATED	Identifying the Determinants of Bleeding and Hypermobility in Patients With Heavy Menstrual Bleeding
NCT05800262	Not specified	COMPLETED	Dynamic Stability Exercises in Patients With Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder
NCT06325345	Not specified	UNKNOWN	RCT of Gut-directed Hypnotherapy in Ehlers-Danlos Syndromes and Generalized Hypermobility Spectrum Disorders
NCT06918613	Not specified	COMPLETED	Ultrasonographic Evaluation of the Effects of Different Wrist Positions on the Median Nerve in Patients With Generalized Joint Hypermobility