Hyperplastic polyp

Summary

Hyperplastic polyp (MONDO:0006249) is a disease and 10 clinical trials. A subtype of polyp — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 10

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	hyperplastic polyp
Mondo ID	MONDO:0006249
EFO	EFO:1000299
NCIT	C4083
UMLS	C0333983
MedGen	87189
Anatomy (UBERON)	UBERON:0001007
Is cancer (heuristic)	no

Also known as: HP · metaplastic polyp · MP

Disease family

This is a subtype of polyp. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › polyp › hyperplastic polyp

Related subtypes (20): epulis, polyp of middle ear, uterine polyp, intestinal polyp, nasal cavity polyp, stomach polyp, neoplastic polyp, polyp of ureter, polyp of large intestine, polyp of vagina, polyp of vulva, polyp of external auditory canal, polyp of sphenoidal sinus, polyp of frontal sinus, polyp of maxillary sinus, polyp of gallbladder, polyp of ethmoidal sinus, polyp of vocal cord, gastrointestinal polyp, fibroepithelial polyp

Subtypes (1): appendix hyperplastic polyp

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 10.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	9
PHASE4	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01133041	PHASE4	COMPLETED	Comparative Study of Postprocessing Imaging Systems for Diminutive Colonic Polyps
NCT07470827	Not specified	ACTIVE_NOT_RECRUITING	Evaluation of ‘WAYMED Endo CL CS’ for Automated Detection and Diagnosis of Colorectal Adenoma and Non-Adenoma Lesions
NCT01729416	Not specified	COMPLETED	Prospective Randomized Controlled Trial Comparing Water and Air Colonoscopy in a Community Based Setting
NCT02009774	Not specified	COMPLETED	Accuracy of the Optical Diagnosis of Small Colonic Polyps Using the Nice Classification
NCT02263144	Not specified	UNKNOWN	Resect and Discard Extension to FICE of NIcE Classification
NCT03297996	Not specified	COMPLETED	Study of Gut Microbiome and Colorectal Tumors
NCT03679429	Not specified	UNKNOWN	NBI Versus White Light Endoscopy for Optical Characterization of Neoplastic Polyps in the Colorectum
NCT03775811	Not specified	COMPLETED	In Vivo Computer-aided Prediction of Polyp Histology on White Light Colonoscopy
NCT04722055	Not specified	COMPLETED	A Multicenter Clinical Trial of Stool-based DNA Testing for Early Detection of Colon Cancer in China
NCT05374369	Not specified	COMPLETED	Retrospective Analysis of Colorectal Cancer Screening Results