Hypersensitivity pneumonitis
diseaseOn this page
Also known as allergic form of pneumonitisallergic interstitial pneumonitisallergic pneumonitisalveolitis, extrinsic allergicexogen allergic alveolitisextrinsic allergic alveolitisextrinsic allergic pneumonia hypersensitivity pneumonitisHP
Summary
Hypersensitivity pneumonitis (MONDO:0017853) is a disease (an umbrella term covering 14 Mondo subtypes) and 30 clinical trials. Top therapeutic interventions include prednisolone and pirfenidone. A subtype of allergic respiratory disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide) [Orphanet-validated]
- Umbrella term: 14 Mondo subtypes
- Clinical trials: 30
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | hypersensitivity pneumonitis |
| Mondo ID | MONDO:0017853 |
| MeSH | D000542 |
| Orphanet | 31740 |
| DOID | DOID:841 |
| NCIT | C34369 |
| SNOMED CT | 37471005 |
| UMLS | C0002390 |
| MedGen | 1446 |
| GARD | 0000012 |
| MedDRA | 10001890 |
| NORD | 761 |
| Is cancer (heuristic) | no |
Also known as: allergic form of pneumonitis · allergic interstitial pneumonitis · allergic pneumonitis · alveolitis, extrinsic allergic · exogen allergic alveolitis · extrinsic allergic alveolitis · extrinsic allergic pneumonia hypersensitivity pneumonitis · HP · hypersensitivity pneumonitis
Data availability: 1 cell line.
Disease family
This is a subtype of allergic respiratory disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › respiratory system disorder › allergic respiratory disease › hypersensitivity pneumonitis
Related subtypes (3): allergic asthma, allergic rhinitis, allergic bronchopulmonary aspergillosis
Subtypes (14): ventilation pneumonitis, bagassosis, farmer’s lung disease, malt worker’s lung, cork-handlers’ disease, maple bark strippers’ lung, bird fancier’s lung, mushroom workers’ lung, sick building syndrome, hypersensitivity pneumonitis, familial, idiopathic chronic eosinophilic pneumonia, house allergic alveolitis, non-fibrotic hypersensitivity pneumonitis, fibrotic hypersensitivity pneumonitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Pirfenidone, Prednisolone.
Clinical trials & evidence
Clinical trials
Clinical trials: 30.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 22 |
| PHASE2 | 4 |
| PHASE4 | 2 |
| PHASE3 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04402177 | PHASE4 | UNKNOWN | This Study Aim is to Compare the Effect of Oral Methyl Prednisolone on Different Radiological Patterns of Hypersensitivity Pneumonitis as it Was Found That Not All Patients Get Satisfying Therapeutic Effect After Taking Corticosteroids. |
| NCT05626387 | PHASE4 | UNKNOWN | An RCT of Mycophenolate Mofetil (MMF) in Fibrotic Hypersensitivity Pneumonitis |
| NCT07210008 | PHASE3 | NOT_YET_RECRUITING | Randomized Controlled Trial Testing the Efficacy of Corticosteroid Therapy Versus Placebo in Fibrotic Hypersensitivity Pneumonitis |
| NCT06329401 | PHASE2 | RECRUITING | A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis |
| NCT02631603 | PHASE2 | TERMINATED | Stop Exogenous Allergic Alveolitis (EAA) in Childhood |
| NCT04675619 | PHASE2 | COMPLETED | Evaluation of the Efficacy of Pirfenidone in Progressive Chronic Hypersensitivity Pneumonitis |
| NCT04677426 | PHASE2 | WITHDRAWN | 129Xe Gas Exchange Imaging in IPF and cHP: A Reliability Study |
| NCT05365802 | EARLY_PHASE1 | RECRUITING | FAPI PET for Lung Fibrosis |
| NCT03800017 | Not specified | RECRUITING | Skeletal Muscle Function in Interstitial Lung Disease |
| NCT04844359 | Not specified | ACTIVE_NOT_RECRUITING | A Prognostic Transcriptomic Signature for Chronic Hypersensitivity Pneumonitis |
| NCT04896138 | Not specified | ENROLLING_BY_INVITATION | University of Virginia Natural History Study |
| NCT05392881 | Not specified | RECRUITING | Interstitial Lung Disease Research Unit Biobank |
| NCT05549635 | Not specified | RECRUITING | Database and Biobank of Patients With Hypersensitivity Pneumonitis |
| NCT05727852 | Not specified | ENROLLING_BY_INVITATION | Breath Analysis and Arterial Stiffness in Patients With Respiratory Diseases |
| NCT05988437 | Not specified | NOT_YET_RECRUITING | Contribution of the Indoor Environment Medical Advisor in the Management of Fibrosing Hypersensitivity Pneumonitis |
| NCT06644144 | Not specified | RECRUITING | P4O2 ILD Extension |
| NCT06811389 | Not specified | RECRUITING | Reimagining Interventions for Support and Education in Hypersensitivity Pneumonitis |
| NCT07577115 | Not specified | ACTIVE_NOT_RECRUITING | Occupational and Environmental Exposures Analysis in Interstitial Lung Diseases. |
| NCT01237145 | Not specified | COMPLETED | Bronchoalveolar Immune Response Determination |
| NCT01487850 | Not specified | COMPLETED | Wind Instruments’ Fungal Contamination |
| NCT02523833 | Not specified | COMPLETED | Small Airway Involvement in Patients With Chronic Hypersensitivity Pneumonitis |
| NCT03300583 | Not specified | COMPLETED | Toward Self-management in ILD |
| NCT03747627 | Not specified | COMPLETED | BPF Genetics of ILD Study |
| NCT03873649 | Not specified | COMPLETED | Immune Response in Hypersensitivity Pneumonitis |
| NCT04273867 | Not specified | COMPLETED | Assessing Health Related Quality of Life in Hypersensitivity Pneumonitis |
| NCT04561479 | Not specified | UNKNOWN | Pulmonary Rehabilitation in Patients With Chronic Fibrotic Hypersensitivity Pneumonitis |
| NCT04961944 | Not specified | UNKNOWN | HypErsensitiVity PneumonITis: DiseAse Progression Characterization |
| NCT05458635 | Not specified | COMPLETED | Predictors of Pulmonary Hypertension in Patients With Hypersensitivity Pneumonitis |
| NCT05723796 | Not specified | COMPLETED | Study of Nasal Mucosa Histopathological Changes in Chronic Hypersensitivity Pneumonitis |
| NCT07169253 | Not specified | COMPLETED | Prognostic Score Comparison in IPF and HP |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| PREDNISOLONE | 4 | 3 |
| PIRFENIDONE | 4 | 1 |
Related Atlas pages
- Drugs: Prednisolone, Pirfenidone