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Atlas / Disease / Hypertensive urgency

Hypertensive urgency

disease
On this page

Also known as hypertensive crisis without acute organ damageseverely elevated blood pressure without acute organ damage

Summary

Hypertensive urgency (MONDO:1030007) is a disease and 15 clinical trials. Top therapeutic interventions include labetalol and nicardipine. A subtype of hypertensive disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Clinical trials: 15

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical namehypertensive urgency
Mondo IDMONDO:1030007
ICD-11956687992
NCITC197914
SNOMED CT443482000
UMLSC0745138
MedGen677063
Is cancer (heuristic)no

Also known as: hypertensive crisis without acute organ damage · severely elevated blood pressure without acute organ damage

Disease family

This is a subtype of hypertensive disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › arterial disorder › hypertensive disorder › hypertensive urgency

Related subtypes (11): essential hypertension, secondary hypertension, pulmonary hypertension, early onset hypertension, chemotherapy-induced hypertension, intracranial hypertension, malignant hypertension, ocular hypertension, kallikrein hypertension, hypertension, pregnancy-induced, resistant hypertension

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 15.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified14
PHASE41

Top trials by phase / activity

NCTPhaseStatusTitle
NCT00765648PHASE4COMPLETEDEvaluation of Intravenous Cardene(Nicardipine)and Labetalol Use in the Emergency Department
NCT03524222Not specifiedRECRUITINGHome Hospital for Suddenly Ill Adults
NCT06635603Not specifiedRECRUITINGHYPERTENSIVE CRISIS AND ATMOSPHERIC PRESSURE RELATIONSHIP
NCT00421239Not specifiedCOMPLETEDRisk Factors of Hypertensive Urgencies
NCT02924805Not specifiedCOMPLETEDTelemedical Versus Conventional Emergency Care of Hypertensive Emergencies
NCT03203759Not specifiedCOMPLETEDHospital-Level Care at Home for Acutely Ill Adults
NCT04080570Not specifiedCOMPLETEDRemote Physician Care for Home Hospital Patients
NCT04531280Not specifiedCOMPLETEDRural Home Hospital: Proof of Concept
NCT04572672Not specifiedCOMPLETEDEffect of Pursed-Lip Breathing on Blood Pressure and Heart Rate
NCT04784351Not specifiedWITHDRAWNPrediction of Expected Length of Hospital Stay Using Machine Learning
NCT04849312Not specifiedCOMPLETEDPrediction of 30-Day Readmission Using Machine Learning
NCT05045742Not specifiedCOMPLETEDPrediction of Patient Deterioration Using Machine Learning
NCT05256303Not specifiedCOMPLETEDRural Hospital-Level Care at Home for Acutely Ill Adults
NCT07272486Not specifiedCOMPLETEDThe Use of Virtual Reality and Music Therapy for Hypertensive Urgency
NCT07493798Not specifiedWITHDRAWNSerum Potassium Prediction Using Machine Learning and Single-lead ECG

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
LABETALOL41
NICARDIPINE41

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 20

This page pulls from 20 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvarefogenccgwasgwas_studyhgncicd11medgenmeshmimmondomondochildmondoparentncitorphanetsctidumls