Hypertrophy of breast
diseaseOn this page
Also known as breast Hypertrophydrug-induced gigantomastia (subtype)gestational gigantomastia (subtype)gigantomastiahypertrophy of the breastidiopathic gigantomastia (subtype)juvenile gigantomastia (subtype)macromastiamedication-induced gigantomastia (subtype)pregnancy-induced gigantomastia (subtype)puberty-induced gigantomastia (subtype)
Summary
Hypertrophy of breast (MONDO:0001100) is a disease and 20 clinical trials. Top therapeutic interventions include bupivacaine hydrochloride. A subtype of breast disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 20
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | hypertrophy of breast |
| Mondo ID | MONDO:0001100 |
| DOID | DOID:10688 |
| ICD-10-CM | N62 |
| ICD-11 | 2078176266 |
| NCIT | C3125 |
| SNOMED CT | 372281005 |
| UMLS | C0020565 |
| MedGen | 43789 |
| Is cancer (heuristic) | no |
Also known as: breast Hypertrophy · drug-induced gigantomastia (subtype) · gestational gigantomastia (subtype) · gigantomastia · hypertrophy of the breast · idiopathic gigantomastia (subtype) · juvenile gigantomastia (subtype) · macromastia · medication-induced gigantomastia (subtype) · pregnancy-induced gigantomastia (subtype) · puberty-induced gigantomastia (subtype)
Disease family
This is a subtype of breast disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › breast disorder › hypertrophy of breast
Related subtypes (14): breast abscess, fat necrosis of breast, breast angiomatosis, breast adenosis, benign mammary dysplasia, breast fibrocystic disease, mastitis, familial juvenile hypertrophy of the breast, supernumerary breasts, isolated congenital breast hypoplasia/aplasia, syndromic breast hypoplasia/aplasia, breast neoplasm, lactation disease, breast implant illness
Subtypes (1): gynecomastia disorder
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 20.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 17 |
| PHASE4 | 3 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05898087 | PHASE4 | RECRUITING | Subpectoral Bupivacaine for Pain Management in Adolescent Reduction Mammaplasty |
| NCT07527039 | PHASE4 | RECRUITING | Pectoral Block in Breast Reduction for Pain Control |
| NCT00558246 | PHASE4 | COMPLETED | Study of Prineo (Dermabond Protape) Versus Sutures in Breast Procedures |
| NCT05233891 | Not specified | RECRUITING | Validation of Scales in Reconstructive Breast Surgery |
| NCT06725459 | Not specified | RECRUITING | NPWT Reduction Mammaplasty |
| NCT00149344 | Not specified | COMPLETED | Vertical Scar Versus Inferior Pedicle Reduction Mammoplasty |
| NCT00149370 | Not specified | COMPLETED | Quality of Life Among Breast Reduction Patients |
| NCT00727025 | Not specified | COMPLETED | Randomized Controlled Trial of Subcuticular Skin Closure Versus Steri-strip S Closure |
| NCT00986453 | Not specified | COMPLETED | PEAK PlasmaBlade 4.0 in Bilateral Breast Reduction |
| NCT01284491 | Not specified | TERMINATED | A Study to Evaluate Cutaneous Scar Quality Following Bilateral Breast Reduction With the PEAK PlasmaBlade 4.0 |
| NCT01297621 | Not specified | COMPLETED | Physical Activity and Sexuality After Reduction Mammaplasty |
| NCT01404351 | Not specified | WITHDRAWN | Use of the PEAK PlasmaBlade 4.0 in Bilateral Breast Reduction |
| NCT02016677 | Not specified | TERMINATED | An Observational Study Exploring the Esthetic Outcomes of Breast Reduction Surgery and /or Mastopexy |
| NCT02769559 | Not specified | COMPLETED | Reduction Mammaplasty and Improved Quality of Life |
| NCT03558880 | Not specified | COMPLETED | Ultrasound Guided Bilateral Erector Spinae Plane Block Versus Tumescent Anesthesia |
| NCT03621345 | Not specified | COMPLETED | Bilateral Ultrasound-Guided Erector Spinae Plane Block For Postoperative Analgesia in Breast Reduction Surgery |
| NCT03669679 | Not specified | COMPLETED | Comparison of Superomedial and Inferior Pedicle Techniques in Mammaplasty |
| NCT04597515 | Not specified | UNKNOWN | Reduction of Breast Enlargement Using the Da Vinci Xi Robot |
| NCT05288530 | Not specified | COMPLETED | Satisfaction, Pain and Function Outcomes of Breast Reduction Patients |
| NCT06611644 | Not specified | COMPLETED | Comparison of ESP and SPSIP Blocks in Breast Surgery |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| BUPIVACAINE HYDROCHLORIDE | 4 | 1 |
Related Atlas pages
- Drugs: Bupivacaine