Hypochondriasis

Summary

Hypochondriasis (MONDO:0001596) is a disease and 15 clinical trials. Top therapeutic interventions include fluoxetine. A subtype of somatoform disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 15

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	hypochondriasis
Mondo ID	MONDO:0001596
MeSH	D006998
DOID	DOID:12883
ICD-10-CM	F45.21
ICD-11	675329566
SNOMED CT	18193002
UMLS	C0020604
MedGen	9382
Is cancer (heuristic)	no

Also known as: hypochondria · hypochondriacal disorder · hypochondriacal neurosis

Disease family

This is a subtype of somatoform disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › somatoform disorder › hypochondriasis

Related subtypes (5): body dysmorphic disorder, neurocirculatory asthenia, somatization disorder, conversion disorder, physiological malfunction arising from mental factor

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 15.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	10
PHASE3	2
PHASE2	2
PHASE1/PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00368212	PHASE3	COMPLETED	Integrated Treatment Program for Hypochondriasis in Primary Care Settings
NCT01119469	PHASE3	COMPLETED	Comparing Cognitive Therapy and Exposure Therapy in Individuals With Hypochondriasis
NCT00208247	PHASE2	COMPLETED	KATHY:Cognitive-behavioural Therapy for Hypochondriasis
NCT00339079	PHASE1/PHASE2	COMPLETED	Treatment of Hypochondriasis With CBT and/or SSRI
NCT00828152	PHASE2	COMPLETED	Internet-delivered Cognitive Behavioral Therapy (CBT) for Health Anxiety
NCT04900064	Not specified	RECRUITING	Evaluation of Primary Care Behavioral Health (PCBH) With the Addition of Self-help CBT - A Randomized Multicenter Trial
NCT05942391	Not specified	ACTIVE_NOT_RECRUITING	Brief-intensive CBT Versus Once-weekly CBT in Anxiety-related Disorders
NCT00959452	Not specified	COMPLETED	Follow up of Patients Treated With Cognitive Behavioural Therapy for Hypochondria From 1997 to 2007
NCT01158430	Not specified	COMPLETED	Acceptance and Commitment Group Therapy (ACT) for Patients With Health Anxiety
NCT01673035	Not specified	COMPLETED	Internet Treatment for Health Anxiety
NCT02131883	Not specified	COMPLETED	Outcome of Cognitive Behavioral Therapy for Patients With Severe Health Anxiety Treated in Group Only. A RCT.
NCT02404116	Not specified	COMPLETED	Metacognitive Therapy for Health Anxiety
NCT02735434	Not specified	COMPLETED	Internet-delivered Acceptance and Commitment Therapy for Patients With Health Anxiety
NCT03024593	Not specified	UNKNOWN	An Examination of the Effects of Health-related Internet Use in Individuals With Pathological Health Anxiety
NCT04921280	Not specified	COMPLETED	Effectiveness of ICBT for Severe Health Anxiety in Clinical Psychiatry.

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
FLUOXETINE	4	1