Hypothalamic neoplasm
diseaseOn this page
Also known as hypothalamic neoplasmshypothalamic tumorhypothalamic tumourhypothalamus neoplasmhypothalamus tumorhypothalamus tumourneoplasm of hypothalamusneoplasm of the hypothalamustumor of hypothalamustumor of the hypothalamustumour of hypothalamustumour of the hypothalamus
Summary
Hypothalamic neoplasm (MONDO:0006799) is a cancer and 3 clinical trials. Top therapeutic interventions include phentermine. A subtype of hypothalamic disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 3
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | hypothalamic neoplasm |
| Mondo ID | MONDO:0006799 |
| EFO | EFO:1000979 |
| MeSH | D007029 |
| DOID | DOID:3644 |
| ICD-11 | 1383549237 |
| NCIT | C3129 |
| SNOMED CT | 254968009 |
| UMLS | C0020659 |
| MedGen | 5717 |
| Anatomy (UBERON) | UBERON:0001898 |
| Is cancer (heuristic) | yes |
Also known as: hypothalamic neoplasms · hypothalamic tumor · hypothalamic tumour · hypothalamus neoplasm · hypothalamus tumor · hypothalamus tumour · neoplasm of hypothalamus · neoplasm of the hypothalamus · tumor of hypothalamus · tumor of the hypothalamus · tumour of hypothalamus · tumour of the hypothalamus
Disease family
An umbrella term covering 1 Mondo subtype.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › brain disorder › thalamic disorder › hypothalamic disorder › hypothalamic neoplasm
Related subtypes (2): Froelich syndrome, hypothalamic dysfunction
Subtypes (1): pituitary tumor
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
2 approved. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Cabergoline | Approved (phase 4) |
| Iopamidol | Approved (phase 4) |
Clinical trials & evidence
Clinical trials
Clinical trials: 3.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 2 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06299891 | PHASE2 | RECRUITING | Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity |
| NCT07396896 | Not specified | RECRUITING | KETO-TUMOR: a Study on Brain Tumors and Central Obesity |
| NCT03137615 | Not specified | COMPLETED | The Cardiovascular Changes Associated With Septal Local Anaesthesia |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| PHENTERMINE | 4 | 3 |
Related Atlas pages
- Drugs: Phentermine