Idiopathic bilateral vestibulopathy

Summary

Idiopathic bilateral vestibulopathy (MONDO:0015743) is a disease and 1 clinical trial. A subtype of otorhinolaryngologic disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Phenotypes (HPO): 11
• Clinical trials: 1

Clinical features

Signs & symptoms

Clinical features (HPO)

11 HPO clinical features (Orphanet curated; top 11 by frequency):

HPO ID	Term	Frequency
HP:0002172	Postural instability	Very frequent (80-99%)
HP:0034773	Oscillopsia	Very frequent (80-99%)
HP:0002141	Gait imbalance	Frequent (30-79%)
HP:0002321	Vertigo	Frequent (30-79%)
HP:0007670	Abnormal vestibulo-ocular reflex	Frequent (30-79%)
HP:6001104	Abnormal vestibulo-spinal reflex	Frequent (30-79%)
HP:0000739	Anxiety	Occasional (5-29%)
HP:0002354	Memory impairment	Occasional (5-29%)
HP:0031987	Diminished ability to concentrate	Occasional (5-29%)
HP:5200273	Sadness	Occasional (5-29%)
HP:0000407	Sensorineural hearing impairment	Excluded (0%)

Identifiers

Disease identifiers

Field	Value
Canonical name	idiopathic bilateral vestibulopathy
Mondo ID	MONDO:0015743
Orphanet	171684
ICD-11	1394072237
SNOMED CT	737580004
UMLS	C4545229
MedGen	1622940
GARD	0020124
Is cancer (heuristic)	no

Disease family

This is a subtype of otorhinolaryngologic disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › otorhinolaryngologic disease › idiopathic bilateral vestibulopathy

Related subtypes (39): bifid nose, autoimmune disease of ear, nose and throat, nasal disorder, atresia of external auditory canal and conductive deafness, external auditory canal atresia-vertical talus-hypertelorism syndrome, laryngeal abductor paralysis, larynx atresia, congenital velopharyngeal incompetence, microtia, congenital tracheal stenosis, laryngeal neuroendocrine neoplasm, arrhinia, laryngotracheal angioma, epignathus, nasolacrimal duct cyst, polyrrhinia, supernumerary nostril, proboscis lateralis, nasal glial heterotopia, nasal ganglioglioma, nasal encephalocele, isolated congenital syngnathia, cysts and fistulae of the face and oral cavity, isolated congenital nasal pyriform aperture stenosis, congenital nasal pyriform aperture stenosis with holoprosencephaly, middle ear anomaly, mal de Debarquement, juvenile nasopharyngeal angiofibroma, tracheal agenesis, semicircular canal dehiscence syndrome, hereditary otorhinolaryngologic disease, supratip dysplasia, recurrent respiratory papillomatosis, silent sinus syndrome, anotia, congenital tracheomalacia, disorder of pharynx, disorder of ear, lip and oral cavity squamous cell carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06476587	Not specified	COMPLETED	Idiopathic Bilateral Vestibulopathy: Peripheral Vestibular Disorders and Their Repercussions