Idiopathic disseminated cytomegalovirus infection

Summary

Idiopathic disseminated cytomegalovirus infection (MONDO:0018108) is a disease. A subtype of cytomegalovirus infection — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 29

Clinical features

Signs & symptoms

Clinical features (HPO)

29 HPO clinical features (Orphanet curated; top 29 by frequency):

HPO ID	Term	Frequency
HP:0002583	Colitis	Very frequent (80-99%)
HP:0033431	Cytomegalovirus colitis	Very frequent (80-99%)
HP:0000554	Uveitis	Frequent (30-79%)
HP:0001287	Meningitis	Frequent (30-79%)
HP:0001824	Weight loss	Frequent (30-79%)
HP:0001945	Fever	Frequent (30-79%)
HP:0002017	Nausea and vomiting	Frequent (30-79%)
HP:0002027	Abdominal pain	Frequent (30-79%)
HP:0002039	Anorexia	Frequent (30-79%)
HP:0002090	Pneumonia	Frequent (30-79%)
HP:0006515	Interstitial pneumonitis	Frequent (30-79%)
HP:0012115	Hepatitis	Frequent (30-79%)
HP:0012486	Myelitis	Frequent (30-79%)
HP:0032118	Retinitis	Frequent (30-79%)
HP:0033993	Viral encephalitis	Frequent (30-79%)
HP:0430087	Anti-cytomegalovirus antibody positivity	Frequent (30-79%)
HP:0000572	Visual loss	Occasional (5-29%)
HP:0000979	Purpura	Occasional (5-29%)
HP:0000988	Skin rash	Occasional (5-29%)
HP:0001289	Confusion	Occasional (5-29%)
HP:0001733	Pancreatitis	Occasional (5-29%)
HP:0001873	Thrombocytopenia	Occasional (5-29%)
HP:0001878	Hemolytic anemia	Occasional (5-29%)
HP:0003326	Myalgia	Occasional (5-29%)
HP:0004936	Venous thrombosis	Occasional (5-29%)
HP:0012223	Splenic rupture	Occasional (5-29%)
HP:0012378	Fatigue	Occasional (5-29%)
HP:0025143	Chills	Occasional (5-29%)
HP:0033117	Duodenitis	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	idiopathic disseminated cytomegalovirus infection
Mondo ID	MONDO:0018108
Orphanet	35062
UMLS	C5680152
MedGen	1826159
GARD	0018811
Is cancer (heuristic)	no

Also known as: idiopathic disseminated CMV infection

Disease family

This is a subtype of cytomegalovirus infection. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › viral infectious disease › primary viral infectious disease › Herpesviridae infectious disease › cytomegalovirus infection › idiopathic disseminated cytomegalovirus infection

Related subtypes (3): cytomegalovirus retinitis, fetal cytomegalovirus syndrome, cytomegalovirus pneumonia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.