Idiopathic gastroparesis
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Summary
Idiopathic gastroparesis (MONDO:0034150) is a disease and 15 clinical trials. Top therapeutic interventions include nortriptyline hydrochloride, olanzapine, and tradipitant. A subtype of gastroparesis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: 1-5 / 10 000 (Specific population) [Orphanet-validated]
- Clinical trials: 15
Clinical features
Epidemiology
Prevalence records
1 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 11.4 | Specific population | Validated |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | idiopathic gastroparesis |
| Mondo ID | MONDO:0034150 |
| Orphanet | 558411 |
| UMLS | C0267171 |
| MedGen | 540450 |
| GARD | 0022249 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of gastroparesis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › stomach disorder › functional gastric disease › gastroparesis › idiopathic gastroparesis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 15.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 7 |
| PHASE2 | 4 |
| PHASE3 | 3 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06836557 | PHASE3 | RECRUITING | Open Label Safety Study of Tradipitant in Idiopathic and Diabetic Gastroparesis |
| NCT00765895 | PHASE3 | COMPLETED | Nortriptyline for Idiopathic Gastroparesis |
| NCT04028492 | PHASE3 | COMPLETED | Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis |
| NCT06899217 | PHASE2 | ACTIVE_NOT_RECRUITING | A Study to Evaluate the Efficacy and Safety of CIN-102 (Deudomperidone) in Adult Subjects With Idiopathic Gastroparesis. |
| NCT03281577 | PHASE2 | COMPLETED | Effect of TAK-954 on Gastrointestinal and Colonic Transit in Diabetic or Idiopathic Gastroparesis Participants |
| NCT03544229 | PHASE2 | COMPLETED | A Study to Evaluate the Efficacy and Safety of TAK-906 in Adult Participants With Symptomatic Idiopathic or Diabetic Gastroparesis |
| NCT04303195 | PHASE2 | COMPLETED | A Study to Evaluate the Safety and Efficacy of NG101 in Adult Participants With Symptomatic Diabetic or Idiopathic Gastroparesis |
| NCT03176927 | EARLY_PHASE1 | COMPLETED | Biomagnetic Characterization of Gastric Dysrhythmias III |
| NCT01793168 | Not specified | RECRUITING | Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford |
| NCT01625923 | Not specified | TERMINATED | A Pilot Study on the Efficacy and Safety of Olanzapine in Gastroparesis |
| NCT01696747 | Not specified | COMPLETED | Gastroparesis Registry 2 |
| NCT01916460 | Not specified | COMPLETED | Intraluminal Endosonography for Examination of the Structural Changes of the Stomach in Gastroparetic Patients |
| NCT02232334 | Not specified | UNKNOWN | Effects of Global Osteopathic Manual Treatments in Patients With Idiopathic Gastroparesis |
| NCT02732821 | Not specified | COMPLETED | G-POEM for Treatment of Refractory Gastroparesis |
| NCT03680859 | Not specified | COMPLETED | Gastroparesis Registry 3 |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| NORTRIPTYLINE HYDROCHLORIDE | 4 | 1 |
| OLANZAPINE | 4 | 1 |
| TRADIPITANT | 3 | 2 |
| FELCISETRAG | 2 | 1 |
| TRAZPIROBEN | 2 | 1 |
Related Atlas pages
- Drugs: Nortriptyline, Olanzapine, Tradipitant