Idiopathic non-lupus full-house nephropathy

Summary

Idiopathic non-lupus full-house nephropathy (MONDO:0035763) is a disease. A subtype of kidney disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 22

Clinical features

Signs & symptoms

Clinical features (HPO)

22 HPO clinical features (Orphanet curated; top 22 by frequency):

HPO ID	Term	Frequency
HP:0000093	Proteinuria	Very frequent (80-99%)
HP:0000083	Renal insufficiency	Frequent (30-79%)
HP:0000100	Nephrotic syndrome	Frequent (30-79%)
HP:0000822	Hypertension	Frequent (30-79%)
HP:0004431	Complement deficiency	Frequent (30-79%)
HP:0005421	Decreased circulating complement C3 concentration	Frequent (30-79%)
HP:0045042	Decreased circulating complement C4 concentration	Frequent (30-79%)
HP:0000099	Glomerulonephritis	Occasional (5-29%)
HP:0000155	Oral ulcer	Occasional (5-29%)
HP:0000988	Skin rash	Occasional (5-29%)
HP:0001369	Arthritis	Occasional (5-29%)
HP:0001919	Acute kidney injury	Occasional (5-29%)
HP:0001966	Mesangial abnormality	Occasional (5-29%)
HP:0002907	Microscopic hematuria	Occasional (5-29%)
HP:0003259	Elevated circulating creatinine concentration	Occasional (5-29%)
HP:0012576	Glomerular C3 deposition	Occasional (5-29%)
HP:0045073	Serositis	Occasional (5-29%)
HP:0100769	Synovitis	Occasional (5-29%)
HP:0002960	Autoimmunity	Excluded (0%)
HP:0020151	Anti-dsDNA antibody positivity	Excluded (0%)
HP:0000707	Abnormality of the nervous system	Very rare (<1-4%)
HP:0002715	Abnormality of the immune system	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	idiopathic non-lupus full-house nephropathy
Mondo ID	MONDO:0035763
Orphanet	567544
UMLS	C5680132
MedGen	1830099
GARD	0022285
Is cancer (heuristic)	no

Also known as: Idiopathic non-lupus FHN

Disease family

This is a subtype of kidney disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › urinary system disorder › kidney disorder › idiopathic non-lupus full-house nephropathy

Related subtypes (56): renal hypertension, kidney failure, nephritis, impaired renal function disease, nephrocalcinosis, atheroembolism of kidney, renal artery disease, nephrosis, cystic kidney disease, anuria, stricture or kinking of ureter, proteinuria, renal infectious disease, diabetes insipidus, orthostatic proteinuria, kidney hypertrophy, chronic kidney disease, hydronephrosis, renal tubular transport disease, kidney cortex necrosis, kidney papillary necrosis, perinephritis, renal aminoaciduria, autosomal dominant progressive nephropathy with hypertension, nephrolithiasis, X-linked diffuse leiomyomatosis-Alport syndrome, tubulointerstitial nephritis and uveitis syndrome, distal renal tubular acidosis, oligomeganephronia, duplication of urethra, renal tubular dysgenesis, exstrophy-epispadias complex, fetal lower urinary tract obstruction, IgG4-related kidney disease, congenital primary megaureter, renal nutcracker syndrome, renal hypoplasia, renal dysplasia, congenital megacalycosis, glomerular disorder, congenital renal artery stenosis, kidney neoplasm, renal tubule disorder, pyonephrosis, Arnold stickler bourne syndrome, C1q nephropathy, hypertensive nephropathy, atypical Fanconi syndrome-neonatal hyperinsulinism syndrome, lachiewicz sibley syndrome, crush syndrome, obstructive nephropathy, inherited kidney disorder, acute tubulointerstitial nephritis, kidney cortex disease, non-syndromic supernumerary kidneys, neonatal renal venous thrombosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.