Ileus

Summary

Ileus (MONDO:0004567) is a disease and 146 clinical trials. Top therapeutic interventions include neostigmine, alvimopan, and prucalopride. A subtype of intestinal obstruction — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 146

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	ileus
Mondo ID	MONDO:0004567
MeSH	D045823
DOID	DOID:8440
NCIT	C37979
SNOMED CT	710572000
UMLS	C1258215
MedGen	219874
Is cancer (heuristic)	no

Disease family

This is a subtype of intestinal obstruction. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › intestinal obstruction › ileus

Related subtypes (5): duodenal obstruction, intestinal volvulus, intestinal impaction, intussusception, encapsulating peritoneal sclerosis

Subtypes (3): intestinal pseudo-obstruction, paralytic ileus, meconium ileus

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 10 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Alvimopan	Phase 3 (in late-stage trials)
Bupivacaine	Phase 3 (in late-stage trials)
Dextrose	Phase 3 (in late-stage trials)
Hydromorphone	Phase 3 (in late-stage trials)
Lidocaine	Phase 3 (in late-stage trials)
Methylnaltrexone	Phase 3 (in late-stage trials)
Mosapride	Phase 3 (in late-stage trials)
Naloxegol	Phase 3 (in late-stage trials)
Sodium Chloride	Phase 3 (in late-stage trials)
Tranexamic Acid	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Asimadoline, Carbon Monoxide, Prucalopride.

Clinical trials & evidence

Clinical trials

Clinical trials: 146.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	82
PHASE2	20
PHASE3	19
PHASE4	17
PHASE1	4
PHASE1/PHASE2	3
PHASE2/PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07412223	PHASE4	NOT_YET_RECRUITING	Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery
NCT00509327	PHASE4	COMPLETED	Randomized Clinical Trial of Bisacodyl Versus Placebo on Postoperative Bowel Motility in Elective Colorectal Surgery
NCT00676377	PHASE4	COMPLETED	A New Approach of Neostigmine in Unavoidable Post Operative Ileus
NCT00708201	PHASE4	COMPLETED	A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy
NCT01440712	PHASE4	COMPLETED	Study of the Effect of Water Soluble Oral Contrast (Gastrografin) on Postoperative Ileus After Colorectal Surgery
NCT01699919	PHASE4	COMPLETED	A Study to Assess Analgesic Efficacy of Intravenous Lignocaine
NCT01835119	PHASE4	UNKNOWN	Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies
NCT01879605	PHASE4	COMPLETED	Study About Effect of Preoperative Bowel Preparation Versus no Bowel Preparation Before Spinal Surgery
NCT01943409	PHASE4	COMPLETED	Intravenous Nutrition in Hospitalized Patients: Comparison of Two Oils
NCT02056405	PHASE4	UNKNOWN	Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery
NCT02161367	PHASE4	COMPLETED	Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery
NCT02425774	PHASE4	COMPLETED	Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway
NCT02958566	PHASE4	UNKNOWN	Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery
NCT03176316	PHASE4	TERMINATED	The Use of Oral Naloxone to Prevent Post Spinal Fusion Ileus
NCT04405037	PHASE4	COMPLETED	Alvimopan as a Rescue Treatment of Postoperative Ileus
NCT05669781	PHASE4	COMPLETED	The Effects of Combined Gum-chewing and Parenteral Metoclopramide on Post-operative Ileus
NCT05985343	PHASE4	COMPLETED	The Impact of Sugammadex on Ileus After Abdominal Wall Reconstruction
NCT05334485	PHASE2/PHASE3	RECRUITING	Pyridostigmine Efficacy and Safety for Treatment of Ileus After Colorectal Surgery
NCT07271875	PHASE3	NOT_YET_RECRUITING	Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery
NCT00205842	PHASE3	COMPLETED	Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative Ileus
NCT00388258	PHASE3	COMPLETED	Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative Ileus
NCT00388401	PHASE3	COMPLETED	Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative Ileus
NCT00388479	PHASE3	COMPLETED	Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/ Postoperative Ileus
NCT00464425	PHASE3	COMPLETED	Electroacupuncture for Postoperative Ileus After Laparoscopic Colorectal Surgery
NCT00528970	PHASE3	COMPLETED	A Study Evaluating Intravenous (IV) MOA-728 for the Treatment of Postoperative Ileus (POI) in Participants After Ventral Hernia Repair
NCT00600158	PHASE3	COMPLETED	Effects of Intravenous Local Anesthetic on Bowel Function After Colectomy
NCT01110382	PHASE3	TERMINATED	A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections
NCT01130675	PHASE3	COMPLETED	Does Coffee Consumption Prevent or Shorten Postoperative Ileus After Colon Resection?
NCT01710982	PHASE3	COMPLETED	Study to Evaluate the Safety of Post-Operative TZP-101 (IV Ulimorelin) After Partial Bowel Resection
NCT01863407	PHASE3	UNKNOWN	Study of Dexamethasone-Allantoin-Metronidazole (DAM) Solution in the Treatment of Post-Operative Ileus (POI)
NCT02059603	PHASE3	UNKNOWN	Electroacupuncture Versus Fast-track Perioperative Program for Laparoscopic Colorectal Surgery
NCT02319512	PHASE3	TERMINATED	Effects of Chewing Gum Against Postoperative Ileus
NCT02524626	PHASE3	COMPLETED	Anti-inflammatory Effect of Peroperative Stimulation of the Vagus Nerve
NCT02742181	PHASE3	TERMINATED	Alvimopan as Rescue in Post op Ileus
NCT02947269	PHASE3	COMPLETED	Prucalopride in Postoperative Ileus
NCT04144933	PHASE3	UNKNOWN	Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery
NCT05470387	PHASE3	TERMINATED	A Study to Evaluate LB1148 for Return of Bowel Function in Subjects Undergoing Bowel Resection
NCT05133024	PHASE2	RECRUITING	Use of Beetroot Juice to Protect Against Postoperative Ileus Following Colorectal Surgery: BEET IT Study
NCT05654649	PHASE1/PHASE2	RECRUITING	Dexamethasone in the Prevention of Post-spinal Paralytic Ileus After Cesarean Section
NCT05923086	PHASE2	RECRUITING	Preventing Gastrointestinal Disturbance in Patients After Longitudinal Laparotomy.

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
NEOSTIGMINE	4	12
ALVIMOPAN	4	10
PRUCALOPRIDE	4	8
CLAVULANIC ACID	4	3
GLYCOPYRRONIUM	4	3
KETOROLAC	4	3
ORPHENADRINE	4	3
SODIUM CHLORIDE	4	3
SUGAMMADEX	4	3
BISACODYL	4	2
METHYLNALTREXONE BROMIDE	4	2
MORPHINE	4	2
BUPIVACAINE HYDROCHLORIDE	4	1
DEXTROSE	4	1
DORIPENEM	4	1
GABAPENTIN	4	1
HYDROMORPHONE HYDROCHLORIDE	4	1
LIDOCAINE	4	1
MEROPENEM	4	1
METHADONE	4	1
METOCLOPRAMIDE	4	1
NALOXONE	4	1
SIMETHICONE	4	1
SORBITOL	4	1
TRAMADOL	4	1
MOSAPRIDE	3	3
ULIMORELIN HYDROCHLORIDE	3	3
LUFENURON	2	1
CHEMBL4059722	0	1
CHEMBL5412674	0	1