Incessant infant ventricular tachycardia

Summary

Incessant infant ventricular tachycardia (MONDO:0018685) is a disease. A subtype of cardiac rhythm disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: 1-9 / 100 000 (Europe) [Orphanet-validated]
• Phenotypes (HPO): 12

Clinical features

Epidemiology

Prevalence records

4 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Point prevalence	1-9 / 100 000		Europe	Validated
Prevalence at birth	1-9 / 100 000	1.5	Europe	Validated
Point prevalence	1-9 / 1 000 000		United Kingdom	Validated
Prevalence at birth	1-9 / 1 000 000	0.3	United Kingdom	Validated

Signs & symptoms

Clinical features (HPO)

12 HPO clinical features (Orphanet curated; top 12 by frequency):

HPO ID	Term	Frequency
HP:0004756	Ventricular tachycardia	Obligate (100%)
HP:0001635	Congestive heart failure	Very frequent (80-99%)
HP:0001695	Cardiac arrest	Very frequent (80-99%)
HP:0006677	Prolonged QRS complex	Very frequent (80-99%)
HP:0011710	Bundle branch block	Very frequent (80-99%)
HP:0031595	Abnormal P wave	Very frequent (80-99%)
HP:0001557	Prenatal movement abnormality	Frequent (30-79%)
HP:0004755	Supraventricular tachycardia	Frequent (30-79%)
HP:0005152	Histiocytoid cardiomyopathy	Frequent (30-79%)
HP:0009729	Cardiac rhabdomyoma	Frequent (30-79%)
HP:0001716	Wolff-Parkinson-White syndrome	Occasional (5-29%)
HP:0025169	Left ventricular systolic dysfunction	Excluded (0%)

Identifiers

Disease identifiers

Field	Value
Canonical name	incessant infant ventricular tachycardia
Mondo ID	MONDO:0018685
Orphanet	45453
ICD-11	1364925734
SNOMED CT	233908008
UMLS	C0340487
MedGen	573762
GARD	0018832
Is cancer (heuristic)	no

Disease family

This is a subtype of cardiac rhythm disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › heart disorder › cardiac rhythm disease › incessant infant ventricular tachycardia

Related subtypes (16): ventricular fibrillation, cardiac arrest, atrial fibrillation, ventricular tachycardia, atrial tachycardia, torsade-de-pointes syndrome with short coupling interval, sinoatrial node dysfunction and deafness, sino-auricular heart block, multifocal atrial tachycardia, His bundle tachycardia, ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome, sudden arrhythmia death syndrome, cardiac conduction defect, sudden cardiac arrest, cardiac conduction disease with or without cardiomyoopathy, cardiogenetic rhythm disorder

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.