Infant botulism
disease diseaseOn this page
Also known as botulism of infancyinfant intestinal botulisminfant intestinal toxaemia botulisminfant intestinal toxemia botulisminfant intestinal toxin-mediated botulisminfantile botulisminfantile onset botulism
Summary
Infant botulism (MONDO:0015804) is a disease and 1 clinical trial. A subtype of intestinal botulism — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: 1-9 / 1 000 000 (Europe) [Orphanet-validated]
- Phenotypes (HPO): 28
- Clinical trials: 1
Clinical features
Epidemiology
Prevalence records
4 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.3 | Europe | Validated |
| Prevalence at birth | 1-9 / 1 000 000 | 0.2 | Europe | Validated |
| Prevalence at birth | 1-9 / 100 000 | 2.1 | United States | Validated |
| Prevalence at birth | 1-9 / 100 000 | 2.2 | Argentina | Validated |
Signs & symptoms
Clinical features (HPO)
28 HPO clinical features (Orphanet curated; top 28 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0000217 | Xerostomia | Very frequent (80-99%) |
| HP:0000298 | Mask-like facies | Very frequent (80-99%) |
| HP:0000508 | Ptosis | Very frequent (80-99%) |
| HP:0000651 | Diplopia | Very frequent (80-99%) |
| HP:0001097 | Keratoconjunctivitis sicca | Very frequent (80-99%) |
| HP:0001252 | Hypotonia | Very frequent (80-99%) |
| HP:0001260 | Dysarthria | Very frequent (80-99%) |
| HP:0001620 | Abnormally high-pitched voice | Very frequent (80-99%) |
| HP:0002015 | Dysphagia | Very frequent (80-99%) |
| HP:0002019 | Constipation | Very frequent (80-99%) |
| HP:0002039 | Anorexia | Very frequent (80-99%) |
| HP:0002307 | Drooling | Very frequent (80-99%) |
| HP:0002360 | Sleep abnormality | Very frequent (80-99%) |
| HP:0006824 | Cranial nerve paralysis | Very frequent (80-99%) |
| HP:0011499 | Mydriasis | Very frequent (80-99%) |
| HP:0100021 | Cerebral palsy | Very frequent (80-99%) |
| HP:0100022 | Abnormality of movement | Very frequent (80-99%) |
| HP:0000600 | Abnormality of the pharynx | Frequent (30-79%) |
| HP:0000822 | Hypertension | Frequent (30-79%) |
| HP:0001284 | Areflexia | Frequent (30-79%) |
| HP:0002094 | Dyspnea | Frequent (30-79%) |
| HP:0002607 | Bowel incontinence | Frequent (30-79%) |
| HP:0002615 | Hypotension | Frequent (30-79%) |
| HP:0002747 | Respiratory insufficiency due to muscle weakness | Frequent (30-79%) |
| HP:0000389 | Chronic otitis media | Occasional (5-29%) |
| HP:0001695 | Cardiac arrest | Occasional (5-29%) |
| HP:0002027 | Abdominal pain | Occasional (5-29%) |
| HP:0002902 | Hyponatremia | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | infant botulism |
| Mondo ID | MONDO:0015804 |
| Orphanet | 178478 |
| DOID | DOID:0050354 |
| ICD-10-CM | A48.51 |
| NCIT | C128343 |
| SNOMED CT | 414488002 |
| UMLS | C0238027 |
| MedGen | 68649 |
| GARD | 0020150 |
| Is cancer (heuristic) | no |
Also known as: botulism of infancy · infant intestinal botulism · infant intestinal toxaemia botulism · infant intestinal toxemia botulism · infant intestinal toxin-mediated botulism · infantile botulism · infantile onset botulism
Disease family
This is a subtype of intestinal botulism. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › primary bacterial infectious disease › botulism › toxin-mediated infectious botulism › intestinal botulism › infant botulism
Related subtypes (1): adult intestinal botulism
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 1.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00004401 | Not specified | COMPLETED | Study of Human Botulism Immunoglobulin in Infants With Botulism |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.