Infectious mononucleosis

Summary

Infectious mononucleosis (MONDO:0005810) is a disease and 12 clinical trials. Top therapeutic interventions include valacyclovir, matrix-m1 adjuvant, and valomaciclovir. A subtype of Epstein-Barr virus infection — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 12

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	infectious mononucleosis
Mondo ID	MONDO:0005810
EFO	EFO:0007326
MeSH	D007244
DOID	DOID:8568
ICD-11	760139952
NCIT	C34726
SNOMED CT	186668002
UMLS	C0021345
MedGen	7069
Is cancer (heuristic)	no

Also known as: Gammaherpesviral mononucleosis · glandular fever · Mono

Data availability: 48 cell lines.

Disease family

This is a subtype of Epstein-Barr virus infection. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › viral infectious disease › primary viral infectious disease › Herpesviridae infectious disease › Epstein-Barr virus infection › infectious mononucleosis

Related subtypes (1): Epstein-Barr virus hepatitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

1 approved. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Idecabtagene Vicleucel	Approved (phase 4)

Clinical trials & evidence

Clinical trials

Clinical trials: 12.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	5
PHASE1/PHASE2	3
PHASE1	2
PHASE2/PHASE3	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00598988	PHASE2/PHASE3	TERMINATED	Acupuncture for Infectious Mononucleosis Trial
NCT00274404	PHASE1/PHASE2	COMPLETED	Controlled Trial of Valacyclovir in Infectious Mononucleosis
NCT00575185	PHASE1/PHASE2	COMPLETED	Activity of Valomaciclovir in Infectious Mononucleosis Due to Primary Epstein-Barr Virus Infection
NCT04138875	PHASE2	WITHDRAWN	A Risk Stratified Sequential Treatment With Rituximab, Brentuximab Vedotin and Bendamustine (RBvB)
NCT05683834	PHASE1/PHASE2	COMPLETED	Trial Evaluating the Immunogenicity and Safety of an Adjuvanted Epstein-Barr Virus (EBV) Glycoprotein 350 Vaccine in EBV-seronegative Persons
NCT04645147	PHASE1	ACTIVE_NOT_RECRUITING	Safety and Immunogenicity of an Epstein-Barr Virus (EBV) gp350-Ferritin Nanoparticle Vaccine in Healthy Adults With or Without EBV Infection
NCT06908096	PHASE1	RECRUITING	Epstein-Barr Virus (EBV) gH/gL/gp42-Ferritin Nanoparticle Vaccine With or Without gp350-Ferritin in Healthy Adults With or Without EBV Infection
NCT04715139	Not specified	RECRUITING	Evaluate the Continued Safety and Performance of the Foot and Ankle Products
NCT02463669	Not specified	TERMINATED	The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency Department
NCT02715037	Not specified	UNKNOWN	Microbiology of Severe Acute Tonsillitis, Peritonsillar Cellulitis, and Infectious Mononucleosis
NCT05225493	Not specified	UNKNOWN	HIV Indicator Diseases in Hospital and Primary Care
NCT06002802	Not specified	COMPLETED	Study on Infectious Mononucleosis in Munich

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
VALACYCLOVIR	4	1
MATRIX-M1 ADJUVANT	3	1
VALOMACICLOVIR	2	1