Infective endocarditis
diseaseOn this page
Also known as endocarditis infectiveendocarditis, infective
Summary
Infective endocarditis (MONDO:0000565) is a disease and 92 clinical trials. Top therapeutic interventions include vancomycin, cefaclor anhydrous, and clindamycin. A subtype of endocarditis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Europe) [Orphanet-validated]
- Clinical trials: 92
Clinical features
Epidemiology
Prevalence records
3 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Annual incidence | 1-9 / 100 000 | Europe | Validated | |
| Annual incidence | 1-9 / 100 000 | 3.38 | France | Validated |
| Annual incidence | 1-9 / 100 000 | 1.8 | Denmark | Validated |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | infective endocarditis |
| Mondo ID | MONDO:0000565 |
| Orphanet | 570762 |
| DOID | DOID:0060000 |
| ICD-11 | 512128824 |
| NCIT | C78265 |
| SNOMED CT | 233850007 |
| UMLS | C1541923 |
| MedGen | 323818 |
| GARD | 0006337 |
| NORD | 1091 |
| Is cancer (heuristic) | no |
Also known as: endocarditis infective · endocarditis, infective
Disease family
This is a subtype of endocarditis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › heart disorder › endocardium disorder › endocarditis › infective endocarditis
Related subtypes (2): marantic endocarditis, Libman-Sacks endocarditis
Subtypes (3): bacterial endocarditis, subacute bacterial endocarditis, mycotic endocarditis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 92.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 78 |
| PHASE4 | 6 |
| PHASE2 | 5 |
| PHASE3 | 3 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05398679 | PHASE4 | RECRUITING | Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis |
| NCT06423898 | PHASE4 | RECRUITING | Ampicillin and Ceftriaxone for the Treatment of Enterococcus Faecalis Infective Endocarditis. |
| NCT07523646 | PHASE4 | RECRUITING | Anemia Therapy in Patients With Infective Endocarditis |
| NCT00624091 | PHASE4 | UNKNOWN | Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) |
| NCT00638157 | PHASE4 | TERMINATED | Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) |
| NCT00871104 | PHASE4 | COMPLETED | Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis |
| NCT07345325 | PHASE3 | NOT_YET_RECRUITING | Rifampin-free Regimen Versus Rifampin-containing Regimen in the Treatment of Staphylococcal Prosthetic Valve Endocarditis |
| NCT02701595 | PHASE3 | COMPLETED | Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus |
| NCT02701608 | PHASE3 | COMPLETED | Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus |
| NCT05446376 | PHASE2 | RECRUITING | Contribution of PET/CT With Gallium 68 Citrate (68Ga-PET/CT) for the Diagnosis of Prosthetic Valve Infective Endocarditis |
| NCT07550595 | PHASE2 | NOT_YET_RECRUITING | Oritavancin for Treatment of Serious Cardiac Infections |
| NCT00695903 | PHASE2 | TERMINATED | Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia |
| NCT05183555 | PHASE2 | COMPLETED | Early Feasibility Study of Somatostatin Receptors PET Imaging for the Diagnosis of Infective Endocarditis |
| NCT05329168 | PHASE2 | WITHDRAWN | ERAdicate S. Aureus in Patients With Bacteremia and Endocarditis |
| NCT03272724 | Not specified | RECRUITING | French National Observatory on Infective Endocarditis |
| NCT04178915 | Not specified | ENROLLING_BY_INVITATION | Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial Infections |
| NCT04647331 | Not specified | RECRUITING | Betalactam Pharmacokinetics in Endocarditis Patients |
| NCT04792281 | Not specified | RECRUITING | Impact of FDG-PET/CT on Management of Patients with Native Valve Infective Endocarditis |
| NCT04992923 | Not specified | RECRUITING | Prospective Cohort Study of Patients With Infective Endocarditis at Pitié-Salpêtrière Hospital |
| NCT05061355 | Not specified | RECRUITING | Antibiotics Vs Antibiotics and Surgical ThERapy for Infective Endocarditis |
| NCT05253469 | Not specified | ENROLLING_BY_INVITATION | Infective Endocarditis Surgery Using Conventional Prosthetic Valves Versus Cryopreserved Aortic Homograft |
| NCT05563662 | Not specified | NOT_YET_RECRUITING | SURgical Registry of ENDocarditis EuRope |
| NCT05721781 | Not specified | RECRUITING | Reducing Risk for Infective Endocarditis |
| NCT05965362 | Not specified | RECRUITING | Prognosis of Patients With Infective Endocarditis and Risk Stratification Value of Biomarkers (ENDEAVOR） |
| NCT06194409 | Not specified | RECRUITING | The Incidence, Clinical Characteristics and Outcome of Infective Endocarditis Among Intravenous Drug Abusers Versus Non-Drug Abusers. |
| NCT06269679 | Not specified | RECRUITING | CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis. |
| NCT06309680 | Not specified | ACTIVE_NOT_RECRUITING | Accuracy of Metagenomic Blood Sampling to Identify Pathogen in Infective Endocarditis Patients |
| NCT06418048 | Not specified | RECRUITING | INfectious DIsease REgistry BIObank |
| NCT06434012 | Not specified | RECRUITING | Barts Endocarditis Research Registry |
| NCT06457386 | Not specified | RECRUITING | Echocardiography Versus no Echocardiography in S. Aureus Bacteraemia and VIRSTA Score < 3 |
| NCT06583902 | Not specified | NOT_YET_RECRUITING | Management of Anemia in Patients with EndocaRditis Infectious Candidates for Cardiac Surgery: the AMERICA Study |
| NCT06704048 | Not specified | RECRUITING | Healthrelated Quality of Life and Experiences of a Heart Rehabilitation Programme After Care for Infective Endocarditis. |
| NCT06745440 | Not specified | NOT_YET_RECRUITING | Belgian Infective Endocarditis Registry |
| NCT06777615 | Not specified | ACTIVE_NOT_RECRUITING | Electronic Archive of Patients With Congenital Heart Disease and Diagnosis of Infective Endocarditis |
| NCT07013552 | Not specified | NOT_YET_RECRUITING | Oritavancin for CIED Infections With MDR Gram-positive Cocci |
| NCT07029295 | Not specified | NOT_YET_RECRUITING | Evaluation of the Impact of a Patient Education Protocol on the Quality of 18F-FDG PET Imaging Indicated for Investigation of Cardiac Inflammation |
| NCT07108803 | Not specified | ENROLLING_BY_INVITATION | European Research Group on Outcomes of Surgical Treatment of Infective Endocarditis |
| NCT07156292 | Not specified | ACTIVE_NOT_RECRUITING | The Epidemiology Change From 2006 to 2022 of Infective Endocarditis in Taiwan |
| NCT07282002 | Not specified | NOT_YET_RECRUITING | Percutaneous AngioVac Vegetation Extraction (PAVE) to Remove Right Heart Vegetations in Patients With Infective Endocarditis |
| NCT07313865 | Not specified | NOT_YET_RECRUITING | From Commensalism to Pathogenicity: Exploring the Pathophysiology of Bacteremia to Better Understand Enterococcus Faecalis Infective Endocarditis |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| VANCOMYCIN | 4 | 4 |
| CEFACLOR ANHYDROUS | 4 | 3 |
| CLINDAMYCIN | 4 | 3 |
| GENTAMICIN | 4 | 3 |
| DAPTOMYCIN | 4 | 2 |
| IMIPENEM ANHYDROUS | 4 | 2 |
| LEVOFLOXACIN ANHYDROUS | 4 | 2 |
| CIPROFLOXACIN | 4 | 1 |
| DICLOXACILLIN | 4 | 1 |
| EDOTREOTIDE GALLIUM GA-68 | 4 | 1 |
| FOSFOMYCIN | 4 | 1 |
| LINEZOLID | 4 | 1 |
| MOXIFLOXACIN | 4 | 1 |
| OFLOXACIN | 4 | 1 |
| ORITAVANCIN | 4 | 1 |
| OXACILLIN | 4 | 1 |
| RIFAMPIN | 4 | 1 |
| SULFAMETHOXAZOLE | 4 | 1 |
| TEDIZOLID | 4 | 1 |
| CHEMBL1649722 | 0 | 2 |
| CHEMBL4286784 | 0 | 2 |
| CHEMBL4744444 | 0 | 2 |
| CHEMBL195892 | 0 | 1 |
| CHEMBL3039597 | 0 | 1 |
| CHEMBL4299436 | 0 | 1 |
| CHEMBL5421678 | 0 | 1 |
| GENTAMICIN C1 | 0 | 1 |
| GENTAMICIN C1A | 0 | 1 |
| GENTAMICIN C2 | 0 | 1 |