Infective vaginitis
diseaseOn this page
Also known as PV - Vaginal infectionVaginal infection
Summary
Infective vaginitis (MONDO:0023557) is a disease and 33 clinical trials. Top therapeutic interventions include dequalinium, doxycycline anhydrous, and terconazole. A subtype of vaginitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 33
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | infective vaginitis |
| Mondo ID | MONDO:0023557 |
| ICD-11 | 1436361154 |
| NCIT | C84353 |
| SNOMED CT | 237091009 |
| UMLS | C0404521 |
| MedGen | 140795 |
| Is cancer (heuristic) | no |
Also known as: PV - Vaginal infection · Vaginal infection · vaginal infection
Disease family
This is a subtype of vaginitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › vaginal disorder › vaginitis › infective vaginitis
Related subtypes (2): postmenopausal atrophic vaginitis, vulvovaginitis
Subtypes (4): bacterial vaginosis, vulvovaginal candidiasis, herpetic vulvovaginitis, trichomonal vulvovaginitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 33.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 19 |
| PHASE3 | 7 |
| PHASE4 | 3 |
| PHASE2 | 3 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01697826 | PHASE4 | COMPLETED | Comparison of Two Topical Formulations Containing Clindamycin and Clotrimazole in Patients With Vaginal Infections |
| NCT03532464 | PHASE4 | COMPLETED | Azithromycin Compared With Doxycycline for Treating Anorectal Chlamydia Trachomatis Infection Concomitant to a Vaginal Infection |
| NCT05788991 | PHASE4 | TERMINATED | Comparison of Dequalinium Chloride (Fluomizin) vs Oral Metronidazole for the Treatment of Bacterial Vaginosis |
| NCT00694928 | PHASE3 | COMPLETED | Vaginal Infection Study 2 |
| NCT01152528 | PHASE3 | UNKNOWN | Va-Sense - Bacterial Vaginosis Once A Week Screening And Treatment To Reduce Infective Complications, Abortion And Preterm Delivery In Pregnant Women With Previous Preterm Delivery |
| NCT02308007 | PHASE3 | COMPLETED | Multi-Center Study of New Medications to Treat Vaginal Infections |
| NCT02308033 | PHASE3 | COMPLETED | Multi-Center Study of New Medications to Treat Vaginal Infections |
| NCT02308046 | PHASE3 | COMPLETED | Multi-Center Study of New Medications to Treat Vaginal Infections |
| NCT05021315 | PHASE3 | UNKNOWN | Vaginal Cleaning Using Povidone Iodine Before CS to Reduce Postoperative Wound Infection |
| NCT05590195 | PHASE3 | UNKNOWN | Effect of PreforPro® on Urinary and Vaginal Health |
| NCT01055106 | PHASE2 | COMPLETED | Dose Ranging Study of Metronidazole Vaginal Gel in the Treatment of Bacterial Vaginosis |
| NCT01593124 | PHASE2 | COMPLETED | Identification of Novel Biomarkers of Cervicovaginal Mucosal Inflammation |
| NCT03372395 | PHASE2 | COMPLETED | Probiotic Implementation as Help in Solving Vaginal Infections |
| NCT01812889 | PHASE1 | COMPLETED | Evaluation of Intravaginal Gel and Ovule Formulations of TOL-463 |
| NCT06530186 | Not specified | NOT_YET_RECRUITING | Evaluation of a Postcoital Sponge on Self-Reported Vaginal Health Parameters |
| NCT00324246 | Not specified | COMPLETED | Feasibility Study of the NEW NORMA-SENSE |
| NCT00802763 | Not specified | UNKNOWN | Performance Proof of the New NORMA-SENSE |
| NCT01542606 | Not specified | WITHDRAWN | Performance Proof of Product Developed to Detect Abnormal Vaginal pH |
| NCT01599416 | Not specified | COMPLETED | Influence of U-relax on Vaginal Health Promotion and HPV DNA Test Change From Positive to Negative |
| NCT01843166 | Not specified | COMPLETED | Vaginal Estrogen With Pessary Treatment |
| NCT03008421 | Not specified | COMPLETED | Oral Probiotics to Reduce Vaginal Group B Streptococcal Colonization in Late Pregnancy |
| NCT03050684 | Not specified | COMPLETED | Does Vaginal Washing Affect the Success Rate of the Labour Induction? |
| NCT03261804 | Not specified | COMPLETED | Relation Between Internal Vaginal Douching and Vaginal Infections in Intrauterine Contraceptive Device Users |
| NCT03898726 | Not specified | COMPLETED | Laparoscopic Versus Transvaginal Cuff Closure |
| NCT04461782 | Not specified | COMPLETED | Interventional Study to Evaluate the Effect of the Oral Administration of L.Plantarum on Vaginal Microbiota |
| NCT04719754 | Not specified | UNKNOWN | Epidemiology of Abnormal Vaginal Discharge During Pregnancy |
| NCT04725981 | Not specified | TERMINATED | Vaginal Stump Infection After Laparoscopic Hysterectomy |
| NCT05005286 | Not specified | COMPLETED | Evaluation of Breastmilk Microbiota as a Function for Immunity |
| NCT05044156 | Not specified | COMPLETED | Investigation of the Relationship Between Salivary Histatine-5 Level and Vaginal Candidiasis in Women |
| NCT05109533 | Not specified | COMPLETED | Probiotics Role in HPV Cervico-vaginal Infection Clearance |
| NCT05557318 | Not specified | UNKNOWN | Using Micro Electro Mechanical Systems to Detect the Air of Vaginal Discharge |
| NCT05806879 | Not specified | UNKNOWN | Impact of Maternity Napkins on the Incidence of Vaginal Infections in the Post-partum Period |
| NCT05997160 | Not specified | UNKNOWN | Research on Vaginal Microbiota Evaluation Unified Standards Based on Gram Staining |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| DEQUALINIUM | 4 | 3 |
| DOXYCYCLINE ANHYDROUS | 4 | 3 |
| TERCONAZOLE | 4 | 2 |
| AZITHROMYCIN | 4 | 1 |
| BUTOCONAZOLE NITRATE | 4 | 1 |
| CLINDAMYCIN | 4 | 1 |
| CLINDAMYCIN PHOSPHATE | 4 | 1 |
| IMIQUIMOD | 4 | 1 |
| NONOXYNOL 9 | 4 | 1 |
| CHEMBL4299381 | 0 | 1 |
| CHEMBL4791312 | 0 | 1 |
| CHEMBL3792763 | 0 | 1 |