Intestinal botulism
diseaseOn this page
Also known as intestinal colonisation botulismintestinal colonization botulismintestinal toxaemia botulismintestinal toxemia botulismintestinal toxin-mediated botulism
Summary
Intestinal botulism (MONDO:0015805) is a disease. A subtype of toxin-mediated infectious botulism — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide)
- Phenotypes (HPO): 13
Clinical features
Signs & symptoms
Clinical features (HPO)
13 HPO clinical features (Orphanet curated; top 13 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0000508 | Ptosis | Very frequent (80-99%) |
| HP:0000651 | Diplopia | Very frequent (80-99%) |
| HP:0001252 | Hypotonia | Very frequent (80-99%) |
| HP:0001260 | Dysarthria | Very frequent (80-99%) |
| HP:0002015 | Dysphagia | Very frequent (80-99%) |
| HP:0006824 | Cranial nerve paralysis | Very frequent (80-99%) |
| HP:0011499 | Mydriasis | Very frequent (80-99%) |
| HP:0000217 | Xerostomia | Frequent (30-79%) |
| HP:0002014 | Diarrhea | Frequent (30-79%) |
| HP:0002017 | Nausea and vomiting | Frequent (30-79%) |
| HP:0001522 | Death in infancy | Occasional (5-29%) |
| HP:0002094 | Dyspnea | Occasional (5-29%) |
| HP:0002747 | Respiratory insufficiency due to muscle weakness | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | intestinal botulism |
| Mondo ID | MONDO:0015805 |
| Orphanet | 178481 |
| DOID | DOID:0050141 |
| SNOMED CT | 409563004 |
| UMLS | C1443901 |
| MedGen | 731170 |
| GARD | 0020151 |
| Is cancer (heuristic) | no |
Also known as: intestinal colonisation botulism · intestinal colonization botulism · intestinal toxaemia botulism · intestinal toxemia botulism · intestinal toxin-mediated botulism
Disease family
This is a subtype of toxin-mediated infectious botulism. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › primary bacterial infectious disease › botulism › toxin-mediated infectious botulism › intestinal botulism
Related subtypes (1): wound botulism
Subtypes (2): infant botulism, adult intestinal botulism
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.