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Atlas / Disease / Intracranial hypertension

Intracranial hypertension

disease
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Summary

Intracranial hypertension (MONDO:0006810) is a disease and 71 clinical trials. Top therapeutic interventions include mannitol, sorbitol, and dexmedetomidine. A subtype of hypertensive disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • ClinVar variants: 1
  • Clinical trials: 71

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical nameintracranial hypertension
Mondo IDMONDO:0006810
EFOEFO:1000992
MeSHD019586
DOIDDOID:9428
UMLSC0151740
MedGen56241
MedDRA10022764
Is cancer (heuristic)no

Data availability: 1 ClinVar variant.

Disease family

This is a subtype of hypertensive disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › arterial disorder › hypertensive disorder › intracranial hypertension

Related subtypes (11): essential hypertension, secondary hypertension, pulmonary hypertension, early onset hypertension, chemotherapy-induced hypertension, malignant hypertension, ocular hypertension, kallikrein hypertension, hypertension, pregnancy-induced, resistant hypertension, hypertensive urgency

Subtypes (2): hypertensive encephalopathy, pseudotumor cerebri

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

ClinVar germline variants

1 retrieved; paginated sample, class counts are floors:

1 uncertain significance

ClinVarVariant (HGVS)GeneClassificationReview
26781946;X;inv(X)(q26q28)dnUncertain significancecriteria provided, single submitter

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Amphotericin B, Dexamethasone, Fluconazole, Flucytosine.

Clinical trials & evidence

Clinical trials

Clinical trials: 71.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified61
PHASE44
PHASE32
PHASE2/PHASE32
PHASE21
PHASE11

Top trials by phase / activity

NCTPhaseStatusTitle
NCT00447018PHASE4COMPLETEDMannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracranial Pressure
NCT00795587PHASE4TERMINATEDComparison of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension and Cerebral Monitoring
NCT02404779PHASE4UNKNOWNTreatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents
NCT06429657PHASE4SUSPENDEDKetamine for Sedation in Severe Traumatic Brain Injury
NCT00286104PHASE3COMPLETEDImpact of Ventricular Catheter Used With Antimicrobial Agents on Patients With a Ventricular Catheter
NCT00319345PHASE2/PHASE3TERMINATEDSodium-Lactate and Traumatic Brain Injury
NCT02130219PHASE2/PHASE3UNKNOWNClinical Value of Noninvasive Intracranial Pressure Measurement
NCT04488874PHASE3COMPLETEDSodium Lactate and Brain Relaxation (LSD)
NCT06634069PHASE2RECRUITINGStudy SOLACE SEPSIS
NCT03373292PHASE1UNKNOWNEndovascular Stenting Treatment for Patients With Internal Jugular Vein Stenosis
NCT04115553Not specifiedACTIVE_NOT_RECRUITINGAssessment of Venous Drainage in Idiopathic Intracranial Hypertension
NCT04459806Not specifiedRECRUITINGIntracranial PrEssure Time dOse (ImPETO)
NCT05340062Not specifiedRECRUITINGNon Invasive Measurement With Trans Cranial Doppler Versus Invasive Measurement in Pediatric Age
NCT05889650Not specifiedRECRUITINGExternal Lumbar Drainage to Reduce ICP in Severe TBI: a Phase 1 Clinical Trial
NCT06057155Not specifiedNOT_YET_RECRUITINGIntracranial Pressure and Optic Nerve Sheath Diameter With CLOSED Bundle
NCT06254534Not specifiedRECRUITINGLidocaine, Dexmedetomidine, Esmolol and Magnesium Effect on Optic Nerve Sheath Diameter After Laryngoscopy
NCT06772155Not specifiedNOT_YET_RECRUITINGSecurity and Effectiveness Assessment of Locking Systems in Ventriculostomy for Traumatic Brain Injury
NCT06776614Not specifiedNOT_YET_RECRUITINGEffectiveness of Surgical Procedures for Acute Cranial Expansion in Traumatic Brain Injury
NCT06928727Not specifiedRECRUITINGOcular Characteristics in Patients With Craniosynostosis
NCT07332234Not specifiedRECRUITINGOptic Nerve Ultrasound for Assessing Cerebral Inflammation and Intracranial Hypertension in Cerebral Pathologies
NCT07420738Not specifiedNOT_YET_RECRUITINGEffects of Extracorporeal Circulation Techniques on Cerebral Perfusion in CABG Surgery
NCT00125229Not specifiedTERMINATEDCerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients
NCT00239525Not specifiedCOMPLETED3-D Transcranial Ultrasound Analysis Study
NCT00437814Not specifiedUNKNOWNEffect of Ketamine (Ketalar) on Intracranial Pressure
NCT00571623Not specifiedCOMPLETEDAutomated Chest Physiotherapy to Improve Outcomes in Neuro
NCT00655304Not specifiedCOMPLETEDThe Effect of Prometheus (R) Liver Support Dialysis on Cerebral Metabolism in Acute Liver Failure
NCT00670124Not specifiedCOMPLETEDHypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure
NCT01126658Not specifiedUNKNOWNEvaluation the Intracranial Volume Pressure Response in Increased Intracranial Pressure
NCT01448681Not specifiedCOMPLETEDA Continuous, Non-Invasive, Real-time Method for Estimating and Predicting Intracranial Hypertension
NCT01850069Not specifiedCOMPLETEDThe Use of Near Infrared Spectroscopy (NIRS) to Estimate Intracranial Pressure (ICP)
NCT01973764Not specifiedTERMINATEDIntraventricular Drain Insertion: Comparison of Ultrasound-guided and Landmark-based Puncture of the Ventricular System
NCT02322970Not specifiedUNKNOWNInvasive Versus Non Invasive Measurement of Intracranial Pressure in Brain Injury Trial (IMPRESSIT)
NCT02507063Not specifiedWITHDRAWNOptic Nerve Sheath Diameter and Intracranial Pressure (ICP) in Children
NCT02558309Not specifiedWITHDRAWNOptic Nerve Head Quantification While Reducing Elevated Intracranial Pressure
NCT02618226Not specifiedCOMPLETEDOptic Nerve Ultrasound in Severe Traumatic Injury
NCT02680704Not specifiedTERMINATEDMechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial Pressure
NCT02695264Not specifiedWITHDRAWNNon-invasive Intracranial Pressure (ICP) Monitoring in Pediatric Patients
NCT02753205Not specifiedWITHDRAWNDexmedetomidine on Optic Nerve Sheath Diameter
NCT02772471Not specifiedCOMPLETEDDevelopment and Evaluation of the ICP Waveform Tracing Capabilities and Safety of HS-1000 Device
NCT02773862Not specifiedCOMPLETEDProspective Evaluation of the Non-invasive ICP HeadSense Monitor in TBI Patients Undergoing Invasive ICP Monitoring

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
MANNITOL43
SORBITOL43
DEXMEDETOMIDINE42
SODIUM LACTATE42
CISATRACURIUM BESYLATE41
HYDROMORPHONE41
PERFLUTREN41
CHEMBL45429901

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 19

This page pulls from 19 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogenccgwasgwas_studyhgncmeddramedgenmeshmimmondomondochildmondoparentorphanetumls