Intracranial meningioma

Summary

Intracranial meningioma (MONDO:0850302) is a disease and 9 clinical trials. Top therapeutic interventions include abemaciclib, bevacizumab, and capivasertib. A subtype of meningioma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 9

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	intracranial meningioma
Mondo ID	MONDO:0850302
DOID	DOID:0060106, DOID:0080842
NCIT	C4656
UMLS	C0349604
MedGen	83891
GARD	0026599
Is cancer (heuristic)	no

Also known as: brain meningioma · brain meningioma (disease) · meningioma (disease) of brain

Data availability: 2 cell lines.

Disease family

This is a subtype of meningioma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › central nervous system neoplasm › tumor of meninges › meningioma › intracranial meningioma

Related subtypes (36): intraspinal meningioma, intraventricular meningioma, intraorbital meningioma, clear cell meningioma, posterior cranial fossa meningioma, anterior cranial fossa meningioma, skull base meningioma, benign meningioma, secretory meningioma, lymphoplasmacyte-rich meningioma, pediatric meningioma, microcystic meningioma, middle cranial fossa meningioma, rhabdoid meningioma, optic nerve sheath meningioma, lung meningioma, malignant leptomeningeal tumor, jugular foramen meningioma, angiomatous meningioma, psammomatous meningioma, fibrous meningioma, meningothelial meningioma, transitional meningioma, petrous apex meningioma, gasserian ganglion meningioma, skin meningioma, periocular meningioma, pineal region meningioma, parapharyngeal meningioma, radiation-induced meningioma, familial meningioma, grade III meningioma, papillary meningioma, optic tract meningioma, grade II meningioma, supratentorial meningioma

Subtypes (3): cerebral meningioma, cerebellopontine angle meningioma, childhood brain meningioma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 9.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	4
PHASE2	3
PHASE3	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03180268	PHASE3	RECRUITING	Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery
NCT02523014	PHASE2	RECRUITING	Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas
NCT00972335	PHASE2	TERMINATED	Trial of the Combination of Bevacizumab and Everolimus in Patients With Refractory, Progressive Intracranial Meningioma
NCT06955169	PHASE2	SUSPENDED	Comparing the Radiopharmaceutical Drug, [177Lu]Lu-DOTATATE, to Standard of Care Treatment for Patients With Meningioma That Has Come Back After Prior Treatment
NCT02084927	PHASE1	UNKNOWN	Hyperbaric Oxygen Therapy Can Improve Neurological State Post Meningioma Removal Surgery
NCT05832099	Not specified	NOT_YET_RECRUITING	Cognition-preserving Brain Irradiation for Treating Patients With Intracranial Meningioma in the Era of Modern Radiotherapeutic Techniques Including Proton Beam Therapy - a Prospective Study Focusing on Radiological Outcomes and Neurocognitive Endpoints
NCT07376473	Not specified	NOT_YET_RECRUITING	Psychometric Validation of the MQOL-FR and Descriptive Assessment of Quality of Life in Patients With Meningiomas
NCT02974127	Not specified	UNKNOWN	Multisession Radiosurgery in Large Meningiomas
NCT04710485	Not specified	UNKNOWN	Sphenoorbital Meningioma Management.

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ABEMACICLIB	4	1
BEVACIZUMAB	4	1
CAPIVASERTIB	4	1
VISMODEGIB	4	1
CHEMBL5190225	0	1