Intraepithelial neoplasia

Summary

Intraepithelial neoplasia (MONDO:0024474) is a disease and 11 clinical trials. Top therapeutic interventions include proflavine. A subtype of epithelial neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 11

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	intraepithelial neoplasia
Mondo ID	MONDO:0024474
NCIT	C8366
UMLS	C0878500
MedGen	164203
Is cancer (heuristic)	no

Also known as: epithelial dysplasia · intraepithelial neoplasia · intraepithelial neoplasm

Disease family

An umbrella term covering 3 Mondo subtypes.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › epithelial neoplasm › intraepithelial neoplasia

Related subtypes (23): ovarian epithelial tumor, myoepithelial tumor, endometrioid tumor, squamous cell neoplasm, pancreatic delta cell neuroendocrine tumor, thyroid hyalinizing trabecular adenoma, Wolffian adnexal tumor, adenoma, carcinoma, cystic, mucinous, and serous neoplasm, thymic epithelial neoplasm, epithelial tumor of anal canal, growth hormone-producing pituitary gland neoplasm, basal cell neoplasm, sympathetic paraganglioma, papillary epithelial neoplasm, epithelial skin neoplasm, glandular cell neoplasm, epithelial neoplasm of rectum, epithelial tumor of colon, mesonephric neoplasm, benign epithelial neoplasm, transitional cell neoplasm

Subtypes (3): prostate intraepithelial neoplasia, small intestinal intraepithelial neoplasia, squamous cell intraepithelial neoplasia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 11.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	8
PHASE3	1
PHASE1/PHASE2	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00352404	PHASE3	COMPLETED	Chromoscopic Guided Endomicroscpy to Diagnose Colitis Associated Dysplasia
NCT01192204	PHASE1/PHASE2	COMPLETED	Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention
NCT01384864	EARLY_PHASE1	COMPLETED	Endoscopic Multispectral Imaging for the Early Detection of Barrett’s Neoplasia
NCT06741150	Not specified	RECRUITING	NWRD09 for HPV-16 Positive and HPV-16 Related Intraepithelial Neoplasia and Cervical Cancer Patients.
NCT07092007	Not specified	RECRUITING	NWRD09 for HPV-16 Related Intraepithelial Neoplasia and Cervical Cancer
NCT01695018	Not specified	COMPLETED	Early Diagnosis of Oral Cancer by Detecting p16 Methylation
NCT01924117	Not specified	COMPLETED	Genotypification and Predisposing Factors in Human Papilloma Virus Infection
NCT02397252	Not specified	COMPLETED	Cervical And Self-Sample In Screening Study
NCT02510027	Not specified	UNKNOWN	Triage Strategies in Cervical Cancer Prevention
NCT02833363	Not specified	UNKNOWN	Difference of Gastric Microbiota in the Process of Correa’s Model.
NCT03195218	Not specified	UNKNOWN	HRME in the Screening of Cervical Cancer Precursor Lesions in Brazil (UH3 - Brazil)

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PROFLAVINE	2	1