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Atlas / Disease / Intrahepatic cholestasis of pregnancy

Intrahepatic cholestasis of pregnancy

disease
On this page

Also known as cholestasis, intrahepatic of pregnancyfamilial intrahepatic cholestasis of pregnancyfamilial recurrent intrahepatic cholestasis of pregnancygravidic intrahepatic cholestasispregnancy related cholestasispregnancy-related cholestasisrecurrent intrahepatic cholestasis of pregnancyRICP

Summary

Intrahepatic cholestasis of pregnancy (MONDO:0100429) is a disease and 22 clinical trials. Top therapeutic interventions include ursodiol, maralixibat, and volixibat. A subtype of intrahepatic cholestasis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Prevalence: Unknown (Europe) [Orphanet-validated]
  • Phenotypes (HPO): 27
  • Clinical trials: 22

Clinical features

Signs & symptoms

Clinical features (HPO)

27 HPO clinical features (Orphanet curated; top 27 by frequency):

HPO IDTermFrequency
HP:0000989PruritusVery frequent (80-99%)
HP:0012202Increased serum bile acid concentrationVery frequent (80-99%)
HP:0002910Elevated circulating hepatic transaminase concentrationFrequent (30-79%)
HP:0025031Abnormality of the digestive systemFrequent (30-79%)
HP:0100785InsomniaFrequent (30-79%)
HP:0100602PreeclampsiaOccasional (5-29%)
HP:0000716DepressionOccasional (5-29%)
HP:0002643Neonatal respiratory distressOccasional (5-29%)
HP:0002904HyperbilirubinemiaOccasional (5-29%)
HP:0003155Elevated circulating alkaline phosphatase concentrationOccasional (5-29%)
HP:0011117Abnormal circulating interleukin concentrationOccasional (5-29%)
HP:0012420Meconium stained amniotic fluidOccasional (5-29%)
HP:0012689Abnormal pineal melatonin secretionOccasional (5-29%)
HP:0030900Pruritus on footOccasional (5-29%)
HP:0031248Palmar pruritusOccasional (5-29%)
HP:0000988Skin rashExcluded (0%)
HP:0002960AutoimmunityExcluded (0%)
HP:0000821HypothyroidismVery rare (<1-4%)
HP:0000952JaundiceVery rare (<1-4%)
HP:0001082CholecystitisVery rare (<1-4%)
HP:0001337TremorVery rare (<1-4%)
HP:0001518Small for gestational ageVery rare (<1-4%)
HP:0001541AscitesVery rare (<1-4%)
HP:0001622Premature birthVery rare (<1-4%)
HP:0001732Abnormality of the pancreasVery rare (<1-4%)
HP:0002027Abdominal painVery rare (<1-4%)
HP:0012164AsterixisVery rare (<1-4%)

Identifiers

Disease identifiers

FieldValue
Canonical nameintrahepatic cholestasis of pregnancy
Mondo IDMONDO:0100429
MeSHC535932
Orphanet69665
DOIDDOID:0070227
ICD-111576251337
UMLSC0268318
MedGen82788
GARD0009804
Is cancer (heuristic)no

Also known as: cholestasis, intrahepatic of pregnancy · familial intrahepatic cholestasis of pregnancy · familial recurrent intrahepatic cholestasis of pregnancy · gravidic intrahepatic cholestasis · intrahepatic cholestasis of pregnancy · pregnancy related cholestasis · pregnancy-related cholestasis · recurrent intrahepatic cholestasis of pregnancy · RICP

Disease family

This is a subtype of intrahepatic cholestasis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › hepatobiliary disorder › biliary tract disorder › bile duct disorder › cholestasis › intrahepatic cholestasis › intrahepatic cholestasis of pregnancy

Related subtypes (1): familial intrahepatic cholestasis

Subtypes (2): cholestasis, intrahepatic, of pregnancy, 1, cholestasis, intrahepatic, of pregnancy, 3

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 22.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified19
PHASE22
PHASE31

Top trials by phase / activity

NCTPhaseStatusTitle
NCT01226823PHASE3WITHDRAWNUrsodeoxycholic Acid And Cholestasis Of Pregnancy
NCT07389031PHASE2NOT_YET_RECRUITINGMaralixibat for Intrahepatic Cholestasis of Pregnancy
NCT04718961PHASE2TERMINATEDA Placebo-controlled Study of Volixibat in Subjects With Elevated Serum Bile Acids Associated With Intrahepatic Cholestasis of Pregnancy (OHANA)
NCT05691036Not specifiedRECRUITINGBile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population
NCT06679972Not specifiedENROLLING_BY_INVITATIONImpact of Intrahepatic Cholestasis of Pregnancy on Neonatal Respiratory Outcomes
NCT07428226Not specifiedRECRUITINGSerum Bile Acid Profiles in Patients With Intrahepatic Cholestasis of Pregnancy
NCT07560722Not specifiedNOT_YET_RECRUITINGThe Effect of a Single Intravenous Injection of Esketamine During Cesarean Section on Postoperative Pruritus in Patients With Intrahepatic Cholestasis of Pregnancy
NCT00700232Not specifiedCOMPLETEDABCB4 Gene Mutations in Intrahepatic Cholestasis of Pregnancy and Controls
NCT01499524Not specifiedCOMPLETEDThe Metabolic Profile in Intrahepatic Cholestasis of Pregnancy and Diabetes Mellitus
NCT01898832Not specifiedUNKNOWNIl-17 Levels in Intrahepatic Cholestasis of Pregnancy
NCT01906827Not specifiedUNKNOWNP-wave Duration and Dispersion in Intrahepatic Cholestasis of Pregnancy
NCT01965054Not specifiedWITHDRAWNThe Use of Fish Oil Supplementation in Treatment of Intrahepatic Cholestasis of Pregnancy
NCT02480478Not specifiedUNKNOWNSerum Autotaxin Levels in Cholestasis of Pregnancy
NCT03519399Not specifiedUNKNOWNBile Acid Effects in Fetal Arrhythmia Study
NCT03834285Not specifiedUNKNOWNLiver Disease in Pregnancy
NCT04890886Not specifiedUNKNOWNMagnetic Resonance Imaging and Thermal Imaging of Adiposity in Neonates of Women With Metabolic Diseases
NCT04922580Not specifiedCOMPLETEDPredictors of Adverse Neonatal Outcomes in Intrahepatic Cholestasis of Pregnancy
NCT05151913Not specifiedCOMPLETEDThe Microbiome Composition in Women With Recurring Intrahepatic Cholestasis of Pregnancy (ICP)
NCT05637151Not specifiedUNKNOWNDifferent Effects of Delayed Clamping on Neonatal Bilirubin Levels Between Pregnant Women With Intrahepatic Cholestasis of Pregnancy and Normal Pregnant Women
NCT05773677Not specifiedUNKNOWNDiet in Twin Pregnancy: the Wellness of Mother and Babies.
NCT06364969Not specifiedUNKNOWNInvestigation of the Pruritogens of Liver-related Diseases
NCT06366659Not specifiedUNKNOWNUnraveling the Pathogenesis of Pruritus in Intrahepatic Cholestasis of Pregnancy

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
URSODIOL42
MARALIXIBAT41
VOLIXIBAT21
CHEMBL540958301
CHEMBL45429901

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 20

This page pulls from 20 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogardgenccgwasgwas_studyhgncicd11medgenmeshmimmondomondochildmondoparentorphanetumls