Intraoperative floppy iris syndrome
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Summary
Intraoperative floppy iris syndrome (MONDO:0041775) is a disease and 8 clinical trials. Top therapeutic interventions include brimonidine tartrate, epinephrine, and racepinephrine. A subtype of iris disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 8
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | intraoperative floppy iris syndrome |
| Mondo ID | MONDO:0041775 |
| ICD-10-CM | H21.81 |
| SNOMED CT | 418801006 |
| UMLS | C1688637 |
| MedGen | 739048 |
| Is cancer (heuristic) | no |
Also known as: intraoperative floppy iris syndrome
Disease family
This is a subtype of iris disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › uveal disorder › iris disorder › intraoperative floppy iris syndrome
Related subtypes (7): pupil disorder, ciliary body disorder, iritis, exfoliation syndrome, aniridia, iris neoplasm, anterior segment dysgenesis 3
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 8.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 5 |
| PHASE4 | 1 |
| PHASE3 | 1 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06266962 | PHASE4 | COMPLETED | Comparing the Efficiency of Two Approaches in Patients at Risk of Developing Intraoperative Floppy Iris Syndrome |
| NCT02093689 | PHASE3 | TERMINATED | Intraoperative Floppy Iris Syndrome Undergoing Intraocular Lens Replacement Surgery |
| NCT03760185 | PHASE2 | COMPLETED | Pupil Dilation for Treatment of IFIS |
| NCT00627913 | Not specified | TERMINATED | Retrobulbar Injection of Anesthesia Versus Healon 5 in the Management of Intraoperative Floppy Iris Syndrome |
| NCT01070602 | Not specified | UNKNOWN | The Effect of Anterior Corneal Incisions on Intraoperative Floppy Iris Syndrome (IFIS) Incidence and Severity in Tamsulosin Treated Cataract Patients |
| NCT01693575 | Not specified | COMPLETED | Use of APX 100 Device for Small-pupil Cataract Surgery and Intraoperative Floppy-iris Syndrome |
| NCT01704014 | Not specified | COMPLETED | Intraoperative Floppy Iris Syndrome in Korean Patients Taking α1-Adrenergic Receptor Antagonists |
| NCT07517094 | Not specified | COMPLETED | Pupillary Dilator Muscle Thickness as a Potential Predictor of Intraoperative Floppy Iris Syndrome |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| BRIMONIDINE TARTRATE | 4 | 1 |
| EPINEPHRINE | 4 | 1 |
| RACEPINEPHRINE | 2 | 1 |
Related Atlas pages
- Drugs: Brimonidine Tartrate, Epinephrine