Irregular astigmatism
diseaseOn this page
Summary
Irregular astigmatism (MONDO:0001831) is a disease and 9 clinical trials. A subtype of astigmatism — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 9
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | irregular astigmatism |
| Mondo ID | MONDO:0001831 |
| DOID | DOID:13919 |
| ICD-10-CM | H52.21 |
| ICD-11 | 1086387343 |
| SNOMED CT | 47099006 |
| UMLS | C0152194 |
| MedGen | 508922 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of astigmatism. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › refractive error › astigmatism › irregular astigmatism
Related subtypes (1): regular astigmatism
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 9.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 9 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04698590 | Not specified | ACTIVE_NOT_RECRUITING | Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism |
| NCT04987060 | Not specified | ACTIVE_NOT_RECRUITING | Intrastromal Fresh Human Corneal Lenticule Implantation Using Smile Surgery for Treatment of Irregular Corneal Astigmatism After Penetrating Keratoplasty (new Approach) |
| NCT06921967 | Not specified | RECRUITING | Effect of Corneal and Scleral RGP Lenses on Ocular Health and Visual Quality in Keratoconus |
| NCT07294716 | Not specified | RECRUITING | Improving Visual Quality in Patients With Irregular Corneas Using Asymmetrical Toric Intraocular Lenses |
| NCT02444923 | Not specified | COMPLETED | Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders |
| NCT02894489 | Not specified | UNKNOWN | Changes of Visual Function, Ocular Surface Structures and Physiology After Long-Termed Contact Lens Wear |
| NCT03140046 | Not specified | COMPLETED | Visual Outcomes of Topography Guided Photorefractive Keratectomy (PRK) for Treatment of Patients With Irregular Cornea |
| NCT05574270 | Not specified | COMPLETED | Clinical Investigation of a Small Aperture Extended Depth of Focus Intraocular Lens in Patients With Complex Corneas |
| NCT06256770 | Not specified | UNKNOWN | Evaluation of the Safety and Efficacy of Rigid Breathable Scleral Contact Lenses for the Correction of Ametropia |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.