Isolated cloverleaf skull syndrome

Summary

Isolated cloverleaf skull syndrome (MONDO:0007861) is a disease. A subtype of isolated craniosynostosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	isolated cloverleaf skull syndrome
Mondo ID	MONDO:0007861
MeSH	C536884
OMIM	148800
Orphanet	2343
SNOMED CT	254022009
UMLS	C0432126
MedGen	98141
GARD	0003115
Is cancer (heuristic)	no

Also known as: cloverleaf skull syndrome · isolated cloverleaf skull syndrome · KLEEBLATTSCHAEDEL · Kleeblattschaedel deformity syndrome · Kleeblattschaedel syndrome · Kleeblattschaedel-deformity syndrome

Disease family

This is a subtype of isolated craniosynostosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › bone development disease › dysostosis › synostosis › craniosynostosis › isolated craniosynostosis › isolated cloverleaf skull syndrome

Related subtypes (3): isolated trigonocephaly, isolated oxycephaly, non-syndromic unisutural craniosynostosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.