Juvenile idiopathic scoliosis

Summary

Juvenile idiopathic scoliosis (MONDO:0100076) is a disease and 5 clinical trials. Top therapeutic interventions include methadone. A subtype of idiopathic scoliosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 5

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	juvenile idiopathic scoliosis
Mondo ID	MONDO:0100076
Orphanet	459696
ICD-10-CM	M41.11
UMLS	C3495538
MedGen	1843471
Is cancer (heuristic)	no

Disease family

This is a subtype of idiopathic scoliosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › disease of bone structure › scoliosis › idiopathic scoliosis › juvenile idiopathic scoliosis

Related subtypes (1): adolescent idiopathic scoliosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 5.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	4
PHASE4	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05730920	PHASE4	COMPLETED	IV Methadone Vs EXPAREL Erector Spinae Plane Blockade in Pediatric Subjects Undergoing Idiopathic Scoliosis Correction
NCT06733623	Not specified	ACTIVE_NOT_RECRUITING	Impact of Spinal Curves on Asymmetric Posture in Idiopathic Scoliosis
NCT04929678	Not specified	TERMINATED	Study of the Braive Growth Modulation System for Progressive Pediatric Scoliosis
NCT04992845	Not specified	TERMINATED	Fusionless Treatment of Idiopathic Scoliosis With the SCOLI-TETHER System During The Growth Period
NCT07527611	Not specified	COMPLETED	Development of a Conservative Care and Bracing Registry (CCBR)

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
METHADONE	4	1