Kienbock disease

Summary

Kienbock disease (MONDO:0019967) is a disease and 2 clinical trials. A subtype of osteochondrosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: 1-9 / 100 000 (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 7
• Clinical trials: 2

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Point prevalence	1-9 / 100 000	6.6	Worldwide	Validated

Signs & symptoms

Clinical features (HPO)

7 HPO clinical features (Orphanet curated; top 7 by frequency):

HPO ID	Term	Frequency
HP:0001376	Limitation of joint mobility	Very frequent (80-99%)
HP:0002653	Bone pain	Very frequent (80-99%)
HP:0002829	Arthralgia	Very frequent (80-99%)
HP:0003019	Abnormality of the wrist	Very frequent (80-99%)
HP:0010885	Avascular necrosis	Very frequent (80-99%)
HP:0010886	Osteochondritis Dissecans	Very frequent (80-99%)
HP:0002758	Osteoarthritis	Frequent (30-79%)

Identifiers

Disease identifiers

Field	Value
Canonical name	Kienbock disease
Mondo ID	MONDO:0019967
Orphanet	97332
UMLS	C0022682
MedGen	44028
GARD	0009690
MedDRA	10064242
NORD	1332
Is cancer (heuristic)	no

Also known as: aseptic necrosis of the lunate bone · bilateral Kienbock’s disease · Kienbock’s disease · Kienböck Disease · Lunatomalacia · osteochondritis of the lunate bone · Osteochondrosis of the lunate bone

Disease family

This is a subtype of osteochondrosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › osteonecrosis › osteochondrosis › Kienbock disease

Related subtypes (10): Osgood-Schlatter disease, Legg-Calve-Perthes disease, Thiemann disease, familial form, Scheuermann disease, dihydropyrimidine dehydrogenase deficiency, osteochondritis of tarsal/metatarsal bone, medial condensing osteitis of the clavicle, panner disease, Sinding-Larsen-Johansson disease, Freiberg disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06460922	Not specified	RECRUITING	3D Printing Models in Surgical Planning of Osteotomies in Kienbock´s Disease Stages II-III
NCT03291015	Not specified	UNKNOWN	Kienbock Disease Radiographic Guided Treatment Versus Arthroscopic Guided Treatment