Lactic acidosis

Summary

Lactic acidosis (MONDO:0006040) is a disease with 10 cohort genes and 22 clinical trials. Top therapeutic interventions include thiamine ion, entecavir anhydrous, and lamivudine.

At a glance

• Cohort genes: 10
• ClinVar variants: 13
• Clinical trials: 22

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	lactic acidosis
Mondo ID	MONDO:0006040
EFO	EFO:1000036
MeSH	D000140
SNOMED CT	91273001
UMLS	C0001125
MedGen	1717
Is cancer (heuristic)	no

Data availability: 13 ClinVar variants · 5 cell lines.

Disease family

An umbrella term covering 3 Mondo subtypes.

Classification path: disease › human disease › disease by developmental or physiological process › metabolic disease › lactic acidosis

Related subtypes (36): glutaric aciduria, mineral metabolism disease, xanthinuria, chondrocalcinosis, ochronosis disorder, glucose metabolism disease, diabetic kidney disease, xanthoma, diabetic retinopathy, hypertriglyceridemia, gout, acquired metabolic disease, lipodystrophy, developmental anomaly of metabolic origin, dopa-responsive dystonia, hypoalphalipoproteinemia, steroid dehydrogenase deficiency-dental anomalies syndrome, inborn errors of metabolism, vitamin B12 deficiency, proteostasis deficiencies, hyperlipidemia, disorder of GPI anchor biosynthesis, bilirubin metabolism disease, hyperlipoproteinemia, carbohydrate metabolism disease, porphyrin metabolism disease, purine metabolism disease, amino acid metabolism disease, pyrimidine metabolism disease, disorder of acid-base balance, disorder of glutamate decarboxylase, tumor lysis syndrome, collagenous sprue, steroid metabolism disease, disorder of organic acid metabolism, skeletal fluorosis

Subtypes (3): mitochondrial DNA depletion syndrome 9, cardiomyopathy-hypotonia-lactic acidosis syndrome, acquired lactic acidosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

ClinVar germline variants

13 retrieved; paginated sample, class counts are floors:

7 pathogenic, 5 pathogenic/likely pathogenic, 1 uncertain significance

ClinVar	Variant (HGVS)	Gene	Classification	Review
976657	NM_024122.5(APOO):c.350T>C (p.Ile117Thr)	APOO	Pathogenic	criteria provided, single submitter
432972	NM_004046.6(ATP5F1A):c.620G>A (p.Arg207His)	ATP5F1A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
523528	NM_020549.5(CHAT):c.1061C>T (p.Thr354Met)	CHAT	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
523529	NM_020549.5(CHAT):c.2081C>G (p.Ser694Cys)	CHAT	Pathogenic	criteria provided, multiple submitters, no conflicts
4795219	NM_001098502.2(CHCHD4):c.5C>T (p.Ser2Phe)	CHCHD4	Pathogenic	no assertion criteria provided
40186	NM_000108.5(DLD):c.1436A>T (p.Asp479Val)	DLD	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
560389	NM_005548.3(KARS1):c.1354del (p.Leu452fs)	KARS1	Pathogenic	criteria provided, single submitter
638209	NM_014672.4(PRORP):c.1334G>A (p.Arg445Gln)	PRORP	Pathogenic/Likely pathogenic	no assertion criteria provided
638210	NM_014672.4(PRORP):c.1197dup (p.Ser400fs)	PRORP	Pathogenic/Likely pathogenic	no assertion criteria provided
619297	NM_006003.3(UQCRFS1):c.215-1G>C	UQCRFS1	Pathogenic	criteria provided, single submitter
619499	NM_006003.3(UQCRFS1):c.610C>T (p.Arg204Ter)	UQCRFS1	Pathogenic	criteria provided, single submitter
4795218	Single allele	WNT7A	Pathogenic	no assertion criteria provided
812762	NM_018297.4(NGLY1):c.758G>T (p.Cys253Phe)	NGLY1	Uncertain significance	criteria provided, single submitter

Genes & proteins

Mendelian disease overlap and somatic drivers

GenCC: 0 · Orphanet: 13 · OMIM-shared: 0 · Dual-evidence (GWAS+Mendelian): 0

Orphanet rare-disease linkage (cohort genes)

Gene	Orphanet ID	Rare disease
UQCRFS1	Orphanet:1460	Isolated complex III deficiency
WNT7A	Orphanet:2854	Fuhrmann syndrome
WNT7A	Orphanet:2879	Phocomelia, Schinzel type
NGLY1	Orphanet:404454	Alacrimia-choreoathetosis-liver dysfunction syndrome
CHAT	Orphanet:98914	Presynaptic congenital myasthenic syndromes
PRORP	Orphanet:642945	Perrault syndrome type 1
PRORP	Orphanet:642976	Perrault syndrome type 2
DLD	Orphanet:2394	Pyruvate dehydrogenase E3 deficiency
KARS1	Orphanet:254334	Autosomal recessive intermediate Charcot-Marie-Tooth disease type B
KARS1	Orphanet:3240	Early-onset progressive leukoencephalopathy-central nervous system calcification-deafness-visual impairment syndrome
KARS1	Orphanet:652532	Adult-onset progressive leukoencephalopathy-early-onset deafness
KARS1	Orphanet:90636	Rare autosomal recessive non-syndromic sensorineural deafness type DFNB
ATP5F1A	Orphanet:254913	Isolated ATP synthase deficiency

Cohort genes → proteins

10 cohort genes, 10 distinct canonical proteins.

Evidence partition

Subset	Genes
multi_evidence	10

Cohort genes (full)

Symbol	HGNC	Ensembl	UniProt	Name	Evidence
UQCRFS1	HGNC:12587	ENSG00000169021	P47985	Cytochrome b-c1 complex subunit Rieske, mitochondrial	clinvar
WNT7A	HGNC:12786	ENSG00000154764	O00755	Protein Wnt-7a	clinvar
NGLY1	HGNC:17646	ENSG00000151092	Q96IV0	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	clinvar
CHAT	HGNC:1912	ENSG00000070748	P28329	Choline O-acetyltransferase	clinvar
PRORP	HGNC:19958	ENSG00000100890	O15091	Mitochondrial ribonuclease P catalytic subunit	clinvar
CHCHD4	HGNC:26467	ENSG00000163528	Q8N4Q1	Mitochondrial intermembrane space import and assembly protein 40	clinvar
APOO	HGNC:28727	ENSG00000184831	Q9BUR5	MICOS complex subunit MIC26	clinvar
DLD	HGNC:2898	ENSG00000091140	P09622	Dihydrolipoyl dehydrogenase, mitochondrial	clinvar
KARS1	HGNC:6215	ENSG00000065427	Q15046	Lysine–tRNA ligase	clinvar
ATP5F1A	HGNC:823	ENSG00000152234	P25705	ATP synthase F(1) complex subunit alpha, mitochondrial	clinvar

Cohort function summary

Lead sentence per gene, UniProt-curated.

Symbol	Protein name	Function (lead sentence)
UQCRFS1	Cytochrome b-c1 complex subunit Rieske, mitochondrial	Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
WNT7A	Protein Wnt-7a	Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway.
NGLY1	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation.
CHAT	Choline O-acetyltransferase	Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
PRORP	Mitochondrial ribonuclease P catalytic subunit	Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5’-ends.
CHCHD4	Mitochondrial intermembrane space import and assembly protein 40	Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes.
APOO	MICOS complex subunit MIC26	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
DLD	Dihydrolipoyl dehydrogenase, mitochondrial	Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex).
KARS1	Lysine–tRNA ligase	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
ATP5F1A	ATP synthase F(1) complex subunit alpha, mitochondrial	Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes o…

Protein-family classification

Druggable: 5 · Difficult: 0 · Unknown: 5 · Druggable fraction: 0.5

Family distribution

Cohort families vs a genome-wide background (hypergeometric, BH-FDR; fold = observed/expected). Counts kept; sorted by enrichment, so the catch-all Other/Unknown bucket no longer leads.

Family	Genes	Fold	FDR
Enzyme (other)	5	6.0×	0.001
Other/Unknown	5	0.9×	0.756

Per-gene assignment

Symbol	Family	Druggable?	EC	InterPro (top 3)
UQCRFS1	Other/Unknown	no		Rieske_TM, Rieske_Fe-S_prot_C, Ubiquinol_cyt_c_Rdtase_Fe-S-su
WNT7A	Other/Unknown	no		Wnt, Wnt7, Wnt_CS
NGLY1	Enzyme (other)	yes	3.5.1.52	Transglutaminase-like, Peptide_N_glycanase_PAW_dom, Galactose-bd-like_sf
CHAT	Enzyme (other)	yes	2.3.1.6	Carn_acyl_trans, CAT-like_dom_sf, Cho/carn_acyl_trans_1_2
PRORP	Enzyme (other)	yes	3.1.26.5	TPR-like_helical_dom_sf, PRORP_C, MRPP3_PIN_dom
CHCHD4	Other/Unknown	no		CHCH, CHCHD4
APOO	Other/Unknown	no		MIC26/MIC27, MIC26/MIC27_animal
DLD	Enzyme (other)	yes	1.2.1.104	Pyr_nuc-diS_OxRdtase, Pyr_nucl-diS_OxRdtase_dimer, Lipoamide_DH
KARS1	Enzyme (other)	yes	6.1.1.6	Lys-tRNA-ligase_II, Aa-tRNA-synt_II, NA-bd_OB_tRNA
ATP5F1A	Other/Unknown	no		ATPase_F1/V1/A1_a/bsu_nucl-bd, ATP_synth_asu_C, ATPase_F1/V1/A1_a/bsu_N

Expression context

Cohort genes with no expression data: 0.

8 cohort genes are a single-cell marker in ≥1 SCXA experiment.

Breadth distribution (Bgee present_calls)

Bucket	Genes
narrow (1-5 tissues)	0
moderate (6-20)	0
broad (>20)	10
unknown	0

Top tissues across cohort

Tissue	Cohort genes
heart right ventricle	3
mucosa of transverse colon	2
endometrium epithelium	2
primordial germ cell in gonad	2
left ventricle myocardium	2
gastrocnemius	1
heart left ventricle	1
cortical plate	1
ventricular zone	1
male germ cell	1
right testis	1
sperm	1
male germ line stem cell (sensu Vertebrata) in testis	1
putamen	1
rectum	1
cardiac muscle of right atrium	1
endothelial cell	1
decidua	1
biceps brachii	1
skeletal muscle tissue of biceps brachii	1

Per-gene tissue summary (top 30)

Symbol	Bgee breadth	FANTOM5 breadth	SCXA	Top tissues
UQCRFS1	134	ubiquitous	marker	gastrocnemius, heart left ventricle, mucosa of transverse colon
WNT7A	96	broad	yes	cortical plate, endometrium epithelium, ventricular zone
NGLY1	290	ubiquitous	marker	sperm, male germ cell, right testis
CHAT	68	tissue_specific	marker	primordial germ cell in gonad, male germ line stem cell (sensu Vertebrata) in testis, putamen
PRORP	177	ubiquitous	yes	primordial germ cell in gonad, rectum, mucosa of transverse colon
CHCHD4	254	ubiquitous	marker	left ventricle myocardium, endothelial cell, cardiac muscle of right atrium
APOO	268	ubiquitous	marker	decidua, heart right ventricle, left ventricle myocardium
DLD	301	ubiquitous	marker	heart right ventricle, biceps brachii, skeletal muscle tissue of biceps brachii
KARS1	299	ubiquitous	marker	gingival epithelium, parietal pleura, endometrium epithelium
ATP5F1A	295	ubiquitous	marker	heart right ventricle, esophagus squamous epithelium, renal medulla

Protein interactions among cohort

Intra-cohort edges: 2.

Hub genes (top 10 by interactor count)

Symbol	Interactor count
ATP5F1A	6,160
DLD	5,041
KARS1	4,681
UQCRFS1	4,001
PRORP	1,894
WNT7A	1,809
CHAT	1,743
CHCHD4	1,663
NGLY1	1,442
APOO	1,293

Intra-cohort edges

A	B	Sources
APOO	CHCHD4	biogrid_interaction
PRORP	UQCRFS1	intact

Structural data

PDB: 9 · AlphaFold-only: 1 · No structure: 0

Cohort genes with PDB structures (top 30)

Symbol	UniProt	PDB entries
DLD	P09622	17
KARS1	Q15046	14
ATP5F1A	P25705	9
CHAT	P28329	8
UQCRFS1	P47985	5
PRORP	O15091	5
CHCHD4	Q8N4Q1	4
WNT7A	O00755	3
NGLY1	Q96IV0	2

AlphaFold-only cohort genes (top 30 by pLDDT)

Symbol	UniProt	pLDDT
APOO	Q9BUR5	74.34

Function

Pathway analysis

Distinct Reactome pathways touched by cohort: 44. Enrichment computed across 10 evidence-associated genes (10 with Reactome annotation).

Pathways by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 10 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

Pathway	Cohort genes	Fold	FDR	Sample cohort genes
OADH complex synthesizes glutaryl-CoA from 2-OA	1	380.7×	0.015	DLD
OGDH complex synthesizes succinyl-CoA from 2-OG	1	285.5×	0.015	DLD
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	1	285.5×	0.015	DLD
Loss-of-function mutations in DBT cause MSUD2	1	285.5×	0.015	DLD
Loss-of-function mutations in DLD cause MSUD3/DLDD	1	285.5×	0.015	DLD
tRNA processing in the mitochondrion	1	228.4×	0.015	PRORP
Branched-chain ketoacid dehydrogenase kinase deficiency	1	228.4×	0.015	DLD
H139Hfs13* PPM1K causes a mild variant of MSUD	1	228.4×	0.015	DLD
Cristae formation	2	69.2×	0.015	APOO, ATP5F1A
Protein localization	2	38.1×	0.015	CHCHD4, ATP5F1A
Mitochondrial protein import	2	33.6×	0.015	CHCHD4, ATP5F1A
Mitochondrial biogenesis	2	33.6×	0.015	APOO, ATP5F1A
Mitochondrial protein degradation	2	22.8×	0.015	DLD, ATP5F1A
Glycine degradation	1	163.1×	0.018	DLD
PDH complex synthesizes acetyl-CoA from PYR	1	163.1×	0.018	DLD
rRNA processing in the mitochondrion	1	126.9×	0.022	PRORP
tRNA modification in the mitochondrion	1	103.8×	0.023	PRORP
Organelle biogenesis and maintenance	2	13.2×	0.023	APOO, ATP5F1A
Regulation of pyruvate dehydrogenase (PDH) complex	1	71.4×	0.032	DLD
Acetylcholine Neurotransmitter Release Cycle	1	67.2×	0.033	CHAT
Formation of ATP by chemiosmotic coupling	1	57.1×	0.036	ATP5F1A
Mitochondrial tRNA aminoacylation	1	51.9×	0.037	KARS1
Branched-chain amino acid catabolism	1	47.6×	0.037	DLD
Cytosolic tRNA aminoacylation	1	43.9×	0.037	KARS1
Complex III assembly	1	43.9×	0.037	UQCRFS1
WNT ligand biogenesis and trafficking	1	42.3×	0.037	WNT7A
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	1	42.3×	0.037	NGLY1
Synthesis of PC	1	40.8×	0.037	CHAT
Signaling by Retinoic Acid	1	40.8×	0.037	DLD
tRNA processing	1	35.7×	0.041	PRORP

GO biological processes by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 10 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

GO term	Cohort genes	Fold	FDR	Sample cohort genes
lysyl-tRNA aminoacylation	1	1685.2×	0.012	KARS1
obsolete L-lysine catabolic process to acetyl-CoA	1	1685.2×	0.012	DLD
asymmetric protein localization involved in cell fate determination	1	1685.2×	0.012	WNT7A
basophil activation involved in immune response	1	842.6×	0.012	KARS1
postsynapse assembly	1	842.6×	0.012	WNT7A
positive regulation of protein localization to presynapse	1	842.6×	0.012	WNT7A
positive regulation of inflammatory response to antigenic stimulus	1	561.7×	0.012	KARS1
acetylcholine biosynthetic process	1	561.7×	0.012	CHAT
skeletal muscle satellite cell activation	1	561.7×	0.012	WNT7A
diadenosine tetraphosphate biosynthetic process	1	561.7×	0.012	KARS1
protein import into mitochondrial intermembrane space	1	561.7×	0.012	CHCHD4
oviduct development	1	561.7×	0.012	WNT7A
mitochondrial tRNA 5’-end processing	1	561.7×	0.012	PRORP
2-oxoglutarate decarboxylation to succinyl-CoA	1	561.7×	0.012	DLD
protein import into the intermembrane space via the disulfide relay system	1	561.7×	0.012	CHCHD4
positive regulation of excitatory synapse assembly	1	561.7×	0.012	WNT7A
branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA	1	421.3×	0.015	DLD
central nervous system vasculogenesis	1	337.0×	0.016	WNT7A
regulation of axon diameter	1	337.0×	0.016	WNT7A
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	1	280.9×	0.017	WNT7A
mitochondrial respiratory chain complex assembly	1	280.9×	0.017	CHCHD4
uterus morphogenesis	1	280.9×	0.017	WNT7A
embryonic axis specification	1	240.7×	0.018	WNT7A
stem cell development	1	240.7×	0.018	WNT7A
pyruvate decarboxylation to acetyl-CoA	1	210.7×	0.018	DLD
cerebellar granule cell differentiation	1	210.7×	0.018	WNT7A
lens fiber cell development	1	210.7×	0.018	WNT7A
positive regulation of epithelial cell proliferation involved in wound healing	1	168.5×	0.022	WNT7A
somatic stem cell division	1	153.2×	0.023	WNT7A
establishment of blood-brain barrier	1	140.4×	0.023	WNT7A

Therapeutics

Drugs indicated for this disease

0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Sodium Dichloroacetate	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Abacavir, Riboflavin, Stavudine.

Drug target analysis

Approved (phase 4): 2 · Phase ≥3: 3 · Phased (≥1): 3 · Undrugged: 7

Druggability breadth: 5 of 10 evidence-associated genes (50%) have a ChEMBL target (buckets above are over the deeply-mined display cohort).

Genes with an approved drug

The molecule shown is one approved compound that hits the gene — not necessarily a drug of choice or one indicated for this disease.

Symbol	Example approved molecule
NGLY1	DACTINOMYCIN
KARS1	IMATINIB

Top cohort targets by molecule count

Symbol	Molecules	Max phase
NGLY1	1	4
CHAT	1	3
KARS1	1	4
UQCRFS1	0	0
WNT7A	0	0
PRORP	0	0
CHCHD4	0	0
APOO	0	0
DLD	0	0
ATP5F1A	0	0

Drugs targeting cohort genes (top 30)

Molecule	Max phase	Targets in cohort
DACTINOMYCIN	4	NGLY1
IMATINIB	4	KARS1
COENZYME_A	3	CHAT

Bioactivity and enzyme data

Enzyme cohort genes (≥1 EC): 5.

Cohort genes with ChEMBL bioactivity (full, sorted by assay count)

Symbol	Assays	Type breakdown
KARS1	46	Binding:45, ADMET:1
NGLY1	9	Binding:9
CHAT	7	Binding:7
ATP5F1A	6	Binding:6
DLD	1	Binding:1

Cohort enzymes (BRENDA EC)

Symbol	EC numbers	Names
NGLY1	3.5.1.52	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase
CHAT	2.3.1.6	choline O-acetyltransferase
PRORP	3.1.26.5	ribonuclease P
DLD	1.2.1.104, 1.2.1.105, 1.4.1.27, 1.8.1.4	pyruvate dehydrogenase system, 2-oxoglutarate dehydrogenase system, glycine cleavage system, dihydrolipoyl dehydrogenase
KARS1	6.1.1.6	lysine-tRNA ligase

Pharmacogenomics

Cohort genes with a PharmGKB record: 10; with CPIC/DPWG dosing guidelines: 0.

No cohort gene has a CPIC/DPWG genotype-guided dosing guideline (PharmGKB).

Chemical tractability of cohort targets

3 approved/phased compounds have measured bioactivity against a cohort gene (and aren’t yet in disease-level trials). This is a research / tractability signal, NOT a therapeutic recommendation — a bioactivity row often reflects off-target or screening binding (e.g. promiscuous kinase inhibitors against a cohort kinase), implying no disease mechanism.

Compound	Max phase	Cohort target (bioactivity)
DACTINOMYCIN	4	NGLY1
IMATINIB	4	KARS1
COENZYME_A	3	CHAT

Druggability pyramid

Cohort genes binned by druggability tier (high → low):

Tier	Definition	Genes	Symbols
A	Approved (phase 4 drug)	2	NGLY1, KARS1
B	Phased (≥1) drug, not yet approved	1	CHAT
C	Druggable family + PDB, no drug	2	PRORP, DLD
D	Druggable family + AlphaFold only, no drug	0
E	Difficult family or no structure, no drug	5	UQCRFS1, WNT7A, CHCHD4, APOO, ATP5F1A

Undrugged target profiles

7 cohort genes are undrugged. Ranked by ‘starting-point quality’ (assay depth + drugged-partner adjacency).

Symbol	ChEMBL assays	Drugged partners (top 3)
UQCRFS1	0	—
WNT7A	0	—
PRORP	0	—
CHCHD4	0	—
APOO	0	—
DLD	1	—
ATP5F1A	6	—

Clinical trials & evidence

Clinical trials

Clinical trials: 22.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	14
PHASE2	3
PHASE4	2
PHASE3	1
PHASE2/PHASE3	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00202228	PHASE4	COMPLETED	Lactate Metabolism Study in HIV Infected Persons
NCT01354652	PHASE4	TERMINATED	Lactic Acidosis During Entecavir(ETV)Treatment
NCT00004490	PHASE3	COMPLETED	Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis
NCT03466528	PHASE2/PHASE3	COMPLETED	Alcohol: Thiamine and or Magnesium 1
NCT00004493	PHASE2	COMPLETED	Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia
NCT01973504	PHASE2	WITHDRAWN	Phase 2c Dose Comparison Study of MP4OX in Trauma
NCT02974257	PHASE2	TERMINATED	Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest
NCT03122678	PHASE1	WITHDRAWN	Thiamine Supplementation in Patients With Septic Shock
NCT07193069	Not specified	RECRUITING	Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning
NCT00004353	Not specified	COMPLETED	Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia
NCT00015015	Not specified	COMPLETED	Dichloroacetate Kinetics, Metabolism and Toxicology
NCT00638040	Not specified	WITHDRAWN	The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression
NCT00874276	Not specified	COMPLETED	Pharmacotoxicology of Trichloroethylene Metabolites
NCT00942123	Not specified	COMPLETED	Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis
NCT01139463	Not specified	COMPLETED	Study of Blood Lactate Levels in Patients Treated With Antipsychotics
NCT01873859	Not specified	COMPLETED	Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media
NCT01901419	Not specified	COMPLETED	Nitroglycerin Infusion During Cardiac Surgery
NCT03126890	Not specified	UNKNOWN	Investigation of the Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse Reactions
NCT03723993	Not specified	WITHDRAWN	Remote Ischemic Preconditioning During Cardiopulmonary Bypass
NCT04975906	Not specified	COMPLETED	The Threshold of Serum Anion Gap as a Screening Tool for Organic Acidosis
NCT05984186	Not specified	COMPLETED	Effect of High Velocity/Hyperoxic Breathing Therapy on Blood Lactate Decline
NCT06727318	Not specified	COMPLETED	Comparison of Peripheral Perfusion Indicators and Lactate Levels

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
THIAMINE ION	4	4
ENTECAVIR ANHYDROUS	4	3
LAMIVUDINE	4	1
MAGNESIUM SULFATE	4	1
NITROGLYCERIN	4	1
RIBOFLAVIN	4	1
DICHLOROACETIC ACID	3	2
SODIUM DICHLOROACETATE	3	2
CHEMBL511565	0	1
CHEMBL5267279	0	1
CHEMBL18314	0	1