Laryngeal disorder
diseaseOn this page
Also known as disease of larynxdisease or disorder of larynxdisorder of larynxdisorder of the larynxlaryngeal diseaselarynx diseaselarynx disease or disorder
Summary
Laryngeal disorder (MONDO:0004382) is a disease (an umbrella term covering 20 Mondo subtypes) with 7 GWAS associations across 23 studies and 35 clinical trials. Top therapeutic interventions include amitriptyline, lansoprazole, and nicotine polacrilex. A subtype of upper respiratory tract disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Umbrella term: 20 Mondo subtypes
- GWAS associations: 7
- Clinical trials: 35
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | laryngeal disorder |
| Mondo ID | MONDO:0004382 |
| EFO | EFO:0009673 |
| MeSH | D007818 |
| DOID | DOID:786 |
| NCIT | C26810 |
| SNOMED CT | 60600009 |
| UMLS | C0023051 |
| MedGen | 7268 |
| Anatomy (UBERON) | UBERON:0001737 |
| Is cancer (heuristic) | no |
Also known as: disease of larynx · disease or disorder of larynx · disorder of larynx · disorder of the larynx · laryngeal disease · laryngeal disorder · larynx disease · larynx disease or disorder
Data availability: 7 GWAS associations (23 studies).
Disease family
This is a subtype of upper respiratory tract disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › respiratory system disorder › upper respiratory tract disorder › laryngeal disorder
Related subtypes (9): uvulitis, adenoid hypertrophy, tonsillitis, acute laryngopharyngitis, nasal cavity disorder, pharyngitis, tracheal disorder, nasopharyngeal disorder, epiglottitis
Subtypes (20): spasmodic dystonia, laryngostenosis, laryngitis, laryngeal abductor paralysis, congenital laryngomalacia, larynx atresia, congenital laryngeal web, H syndrome, primary laryngeal lymphangioma, congenital laryngeal palsy, congenital subglottic stenosis, congenital laryngeal cyst, laryngocele, laryngeal diphtheria, laryngeal granuloma, laryngeal neoplasm, polyp of vocal cord, voice disorders, acquired laryngomalacia, idiopathic subglottic stenosis
Genetics & variants
GWAS landscape
7 GWAS associations across 23 studies. Top hits map to 5 distinct genes (as reported by GWAS).
Top associations by p-value
| rsID | p-value | Gene | Risk allele | Odds ratio |
|---|---|---|---|---|
| rs191397191 | 5e-13 | CCDC91 | C | 2.64 |
| rs151235861 | 2e-12 | KLHL2 | C | 3.53 |
| rs535050546 | 2e-12 | PLG | G | 3.63 |
| rs183853411 | 2e-11 | RNA5SP356 - IPO8 | G | 2.64 |
| rs145580153 | 4e-11 | ARHGAP21 | A | 2.17 |
| rs9571792 | 1e-08 | LINC00364 - BCRP9 | ? | |
| rs77526861 | 5e-07 | CDH9 | ? |
Top studies (by case count)
| Study | Lead author | Year | Cases | Controls | Title |
|---|---|---|---|---|---|
| GCST90478089 | Verma A | 2024 | 18,793 | 419,505 | Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. |
| GCST90478088 | Verma A | 2024 | 4,969 | 113,682 | Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. |
| GCST90481079 | Verma A | 2024 | 4,969 | 113,682 | Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. |
| GCST90473696 | UK Biobank Whole-Genome Sequencing Consortium | 2025 | 4,024 | 454,416 | Whole-genome sequencing of 490,640 UK Biobank participants. |
| GCST90038671 | Donertas HM | 2021 | 3,945 | 480,653 | Common genetic associations between age-related diseases. |
| GCST90436197 | Zhou W | 2018 | 2,630 | 390,045 | Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies. |
| GCST90269776 | Saarentaus EC | 2023 | 2,623 | 199,208 | Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation. |
| GCST90080122 | Backman JD | 2021 | 2,136 | 385,278 | Exome sequencing and analysis of 454,787 UK Biobank participants. |
| GCST90084108 | Backman JD | 2021 | 2,136 | 385,278 | Exome sequencing and analysis of 454,787 UK Biobank participants. |
| GCST90652147 | Liu TY | 2025 | 2,126 | 185,643 | Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population. |
Variant details and genetic-evidence tiers
Tier distribution (top 50 variants)
| Tier | Variants |
|---|---|
| Tier 1: coding | 0 |
| Tier 2: splice/UTR | 0 |
| Tier 3: regulatory | 0 |
| Tier 4: intronic/intergenic | 7 |
MAF distribution
| Bucket | Variants |
|---|---|
| common (>=0.05) | 0 |
| low_freq (0.01-0.05) | 0 |
| rare (<0.01) | 5 |
| unknown | 2 |
Functional consequences
| Consequence | Count |
|---|---|
| intergenic_variant | 3 |
| intron_variant | 3 |
| synonymous_variant | 1 |
Top variants
| rsID | Chr | Pos | Alleles | MAF | Consequence | Gene | p-value | Tier |
|---|---|---|---|---|---|---|---|---|
| rs191397191 | 12 | 28576652 | C>T | 0.001 | intergenic_variant | CCDC91 | 5e-13 | Tier 4: intronic/intergenic |
| rs151235861 | 4 | 165310722 | C>T | 0 | synonymous_variant | KLHL2 | 2e-12 | Tier 4: intronic/intergenic |
| rs535050546 | 6 | 160739716 | G>A,C | 0 | intron_variant | PLG | 2e-12 | Tier 4: intronic/intergenic |
| rs183853411 | 12 | 30328229 | G>A | 0 | intergenic_variant | RNA5SP356 - IPO8 | 2e-11 | Tier 4: intronic/intergenic |
| rs145580153 | 10 | 24689219 | A>G | 0.001 | intron_variant | ARHGAP21 | 4e-11 | Tier 4: intronic/intergenic |
| rs9571792 | 13 | 67501827 | A>G | intergenic_variant | LINC00364 - BCRP9 | 1e-08 | Tier 4: intronic/intergenic | |
| rs77526861 | 5 | 26993472 | C>A | intron_variant | CDH9 | 5e-07 | Tier 4: intronic/intergenic |
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 35.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 26 |
| PHASE4 | 4 |
| PHASE3 | 2 |
| PHASE2/PHASE3 | 2 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06507202 | PHASE4 | RECRUITING | Comparison of Remimazolam and Propofol for Recovery of Ambulatory Upper Airway Surgery |
| NCT00372918 | PHASE4 | COMPLETED | Interpretation of Transnasal Esophagoscopy Findings |
| NCT00373997 | PHASE4 | COMPLETED | Esophageal and Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux |
| NCT00444145 | PHASE4 | COMPLETED | Do Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux Predict Response to Treatment? |
| NCT00335283 | PHASE3 | COMPLETED | Efficacy of Lansoprazole in Chronic Post Nasal Drip |
| NCT00567658 | PHASE3 | WITHDRAWN | Effect of Acid Suppression With Esomeprazole on Vocal Cord Granulomas |
| NCT02434523 | PHASE2/PHASE3 | TERMINATED | Trial of the Treatment of Chronic Laryngitis With Amitryptiline |
| NCT02552225 | PHASE2/PHASE3 | TERMINATED | Treatment of Chronic Laryngitis With Amitriptyline |
| NCT06634823 | EARLY_PHASE1 | RECRUITING | Efficacy of Intramuscular Steroid Injection for Chronic Cough. |
| NCT03429036 | Not specified | RECRUITING | Biospecimen Procurement for Head and Neck Disorders |
| NCT06078527 | Not specified | NOT_YET_RECRUITING | Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort |
| NCT06303180 | Not specified | RECRUITING | NIDCD Otolaryngology Clinical Protocol Biospecimen Bank |
| NCT06559293 | Not specified | NOT_YET_RECRUITING | Pilot Feasibility Study of Laryngeal Ultrasound in the Paediatric Population - ECHO LARYNX |
| NCT06600919 | Not specified | RECRUITING | Effect of Passive Music Therapy Via an App on Anxiety Prevention in ENT Surgery |
| NCT07326358 | Not specified | RECRUITING | AI System for Anatomic Recognition & Lesion Detection in Nasopharyngolaryngoscopy: A Prospective Study |
| NCT07434583 | Not specified | RECRUITING | Force Sensor Study |
| NCT00001552 | Not specified | COMPLETED | Characteristics of Idiopathic Familial Voice Disorders |
| NCT00388453 | Not specified | COMPLETED | Efficacy of Dx-pH Probe in Diagnosing Extra-esophageal Reflux Disease |
| NCT01276418 | Not specified | COMPLETED | ENT FiberLase CO2 Study |
| NCT01360580 | Not specified | COMPLETED | Swallowing Disorders After Prolonged Mechanical Ventilation |
| NCT01507792 | Not specified | COMPLETED | Iron Repletion in Chronic Cough and Iron Deficiency |
| NCT02960243 | Not specified | COMPLETED | Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres? |
| NCT03214835 | Not specified | WITHDRAWN | CDx Biopsies for Detection of Laryngopharyngeal Reflux and Laryngeal Lesions |
| NCT03269396 | Not specified | SUSPENDED | Laryngeal Allograft Transplantation |
| NCT03450694 | Not specified | UNKNOWN | Role of Ultrasound in Laryngeal Lesions |
| NCT03843580 | Not specified | COMPLETED | Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Could Decrease the Incidence of Oxygen Desaturation During Suspension Laryngoscopy: a Randomized Controlled Trial (Optilaryngo) |
| NCT04231344 | Not specified | COMPLETED | Laryngeal Disorders and GERD in Assiut University |
| NCT04369040 | Not specified | TERMINATED | Comparison of Two Ventilation Methods for Micro-Laryngeal Surgery |
| NCT04575142 | Not specified | COMPLETED | Comparison of Office-based KTP and CO2 Laser Outcomes in Patients With Vocal Cord Lesions. |
| NCT04734483 | Not specified | UNKNOWN | The Effectiveness of Reconstructive Microsurgery on the Clinical and Functional State of Laryngeal Stenosis |
| NCT04777474 | Not specified | UNKNOWN | Benefit of Enhanced Contact Endoscopy in Pre-histological Diagnosis of Laryngeal and Hypopharyngeal Mucosal Lesions |
| NCT05198219 | Not specified | UNKNOWN | Procedural Efficiency and Organisational Impact of Rhino Laryngoscopes Procedures in Consults |
| NCT05400642 | Not specified | UNKNOWN | Randomized Controlled Trial:High-flow Oxygen Therapy and Tracheal Intubation for Laryngeal Microsurgery |
| NCT06316063 | Not specified | COMPLETED | Hemodynamic Effects of Apnoeic Oxygenation With High-flow Nasal Oxygen in Adults Undergoing Laryngeal Surgery |
| NCT06398899 | Not specified | COMPLETED | Sugammadex v.s. Neostigmine/Glycopyrrolate |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| AMITRIPTYLINE | 4 | 6 |
| LANSOPRAZOLE | 4 | 2 |
| NICOTINE POLACRILEX | 4 | 1 |
| REMIMAZOLAM | 4 | 1 |