Legionnaires' disease
disease diseaseOn this page
Also known as Legionella pneumonia
Summary
Legionnaires’ disease (MONDO:0005824) is a disease and 4 clinical trials. A subtype of bacterial pneumonia — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: 1-9 / 100 000 (Europe) [Orphanet-validated]
- Phenotypes (HPO): 42
- Clinical trials: 4
Clinical features
Epidemiology
Prevalence records
31 prevalence record(s), Orphanet, top 20 (validated / broadest geography first):
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Annual incidence | 1-9 / 100 000 | 1.4 | Europe | Validated |
| Annual incidence | 1-9 / 100 000 | 2.5 | France | Validated |
| Annual incidence | 1-9 / 100 000 | 1.82 | Austria | Validated |
| Annual incidence | 1-9 / 100 000 | 1.38 | Belgium | Validated |
| Annual incidence | 1-9 / 1 000 000 | 0.8 | Croatia | Validated |
| Annual incidence | 1-9 / 1 000 000 | 0.42 | Cyprus | Validated |
| Annual incidence | 1-9 / 100 000 | 1.24 | Czech Republic | Validated |
| Annual incidence | 1-9 / 100 000 | 3.18 | Denmark | Validated |
| Annual incidence | 1-9 / 1 000 000 | 0.84 | Estonia | Validated |
| Annual incidence | 1-9 / 1 000 000 | 0.32 | Finland | Validated |
| Annual incidence | 1-9 / 100 000 | 1.18 | Germany | Validated |
| Annual incidence | 1-9 / 1 000 000 | 0.3 | Greece | Validated |
| Annual incidence | 1-9 / 1 000 000 | 0.5 | Hungary | Validated |
| Annual incidence | 1-9 / 1 000 000 | 0.83 | Iceland | Validated |
| Annual incidence | 1-9 / 1 000 000 | 0.28 | Ireland | Validated |
| Annual incidence | 1-9 / 100 000 | 2.72 | Italy | Validated |
| Annual incidence | 1-9 / 100 000 | 1.5 | Latvia | Validated |
| Annual incidence | 1-9 / 1 000 000 | 0.28 | Lithuania | Validated |
| Annual incidence | 1-9 / 100 000 | 1.02 | Luxembourg | Validated |
| Annual incidence | 1-9 / 100 000 | 1.88 | Malta | Validated |
Signs & symptoms
Clinical features (HPO)
42 HPO clinical features (Orphanet curated; top 42 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0001945 | Fever | Very frequent (80-99%) |
| HP:0002088 | Abnormal lung morphology | Very frequent (80-99%) |
| HP:0002113 | Pulmonary infiltrates | Very frequent (80-99%) |
| HP:0003326 | Myalgia | Very frequent (80-99%) |
| HP:0012378 | Fatigue | Very frequent (80-99%) |
| HP:0012735 | Cough | Very frequent (80-99%) |
| HP:0002093 | Respiratory insufficiency | Frequent (30-79%) |
| HP:0011675 | Arrhythmia | Frequent (30-79%) |
| HP:0100749 | Chest pain | Frequent (30-79%) |
| HP:0000083 | Renal insufficiency | Occasional (5-29%) |
| HP:0000093 | Proteinuria | Occasional (5-29%) |
| HP:0000738 | Hallucinations | Occasional (5-29%) |
| HP:0000790 | Hematuria | Occasional (5-29%) |
| HP:0000952 | Jaundice | Occasional (5-29%) |
| HP:0001251 | Ataxia | Occasional (5-29%) |
| HP:0001324 | Muscle weakness | Occasional (5-29%) |
| HP:0001701 | Pericarditis | Occasional (5-29%) |
| HP:0001733 | Pancreatitis | Occasional (5-29%) |
| HP:0001744 | Splenomegaly | Occasional (5-29%) |
| HP:0001888 | Lymphopenia | Occasional (5-29%) |
| HP:0002014 | Diarrhea | Occasional (5-29%) |
| HP:0002017 | Nausea and vomiting | Occasional (5-29%) |
| HP:0002027 | Abdominal pain | Occasional (5-29%) |
| HP:0002039 | Anorexia | Occasional (5-29%) |
| HP:0002076 | Migraine | Occasional (5-29%) |
| HP:0002091 | Restrictive ventilatory defect | Occasional (5-29%) |
| HP:0002103 | Abnormality of the pleura | Occasional (5-29%) |
| HP:0002105 | Hemoptysis | Occasional (5-29%) |
| HP:0002383 | Infectious encephalitis | Occasional (5-29%) |
| HP:0002615 | Hypotension | Occasional (5-29%) |
| HP:0002716 | Lymphadenopathy | Occasional (5-29%) |
| HP:0002829 | Arthralgia | Occasional (5-29%) |
| HP:0002902 | Hyponatremia | Occasional (5-29%) |
| HP:0004372 | Reduced consciousness/confusion | Occasional (5-29%) |
| HP:0005528 | Bone marrow hypocellularity | Occasional (5-29%) |
| HP:0009830 | Peripheral neuropathy | Occasional (5-29%) |
| HP:0012115 | Hepatitis | Occasional (5-29%) |
| HP:0012819 | Myocarditis | Occasional (5-29%) |
| HP:0100584 | Endocarditis | Occasional (5-29%) |
| HP:0100658 | Cellulitis | Occasional (5-29%) |
| HP:0100776 | Recurrent pharyngitis | Occasional (5-29%) |
| HP:0100806 | Sepsis | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | Legionnaires’ disease |
| Mondo ID | MONDO:0005824 |
| EFO | EFO:0007343 |
| MeSH | D007877 |
| Orphanet | 549 |
| DOID | DOID:10457 |
| ICD-10-CM | A48.1 |
| ICD-11 | 424434722 |
| NCIT | C128339 |
| SNOMED CT | 195889001 |
| UMLS | C0023241 |
| MedGen | 9705 |
| GARD | 0024237 |
| NORD | 1354 |
| Is cancer (heuristic) | no |
Also known as: Legionella pneumonia · Legionnaires’ Disease
Disease family
This is a subtype of bacterial pneumonia. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › bacterial pneumonia › Legionnaires’ disease
Related subtypes (7): anaerobic pneumonia, Mycoplasma pneumoniae pneumonia, staphylococcal pneumonia, streptococcal pneumonia, Klebsiella pneumonia, pneumonia caused by pseudomonas aeruginosa infection, pneumonia caused by gram negative bacteria
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 4.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 4 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01784770 | Not specified | COMPLETED | Special Investigation Of Azithromycin IV For Legionnaires’ Disease (Regulatory Post Marketing Commitment Plan) |
| NCT02884700 | Not specified | COMPLETED | Severe Legionellosis Cases Admitted to Grenoble University Hospital, 2006-2011. |
| NCT03321786 | Not specified | COMPLETED | Legionnaires’ Effect on Smell |
| NCT04106037 | Not specified | COMPLETED | Nosocomial and Community Acquired Legionella Pneumophila Pneumonia. |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.