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Atlas / Disease / Leptospirosis

Leptospirosis

disease
On this page

Also known as cane-cutter fevercanicola feverhemorrhagic jaundiceIcterohemorrhagic feverLeptospira caused disease or disorderLeptospira disease or disorderLeptospira infectious diseasemud fevernanukayami feverrice-field feverStuttgart diseaseswamp feverswineherd's diseaseWeil disease

Summary

Leptospirosis (MONDO:0005825) is a disease and 22 clinical trials. Top therapeutic interventions include desmopressin and dexamethasone. A subtype of primary bacterial infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Prevalence: 1-9 / 1 000 000 (Europe) [Orphanet-validated]
  • Phenotypes (HPO): 40
  • Clinical trials: 22

Clinical features

Epidemiology

Prevalence records

27 prevalence record(s), Orphanet, top 20 (validated / broadest geography first):

TypeClassValueGeographyValidation
Annual incidence1-9 / 1 000 0000.12EuropeValidated
Annual incidence1-9 / 1 000 0000.92FranceValidated
Annual incidence1-9 / 1 000 0000.12AustriaValidated
Annual incidence1-9 / 1 000 0000.12BelgiumValidated
Annual incidence1-9 / 1 000 0000.18BulgariaValidated
Annual incidence1-9 / 100 0001.13CroatiaValidated
Annual incidence1-9 / 1 000 0000.22Czech RepublicValidated
Annual incidence1-9 / 1 000 0000.12DenmarkValidated
Annual incidence1-9 / 1 000 0000.24EstoniaValidated
Annual incidence<1 / 1 000 0000.02FinlandValidated
Annual incidence1-9 / 1 000 0000.12GermanyValidated
Annual incidence1-9 / 1 000 0000.22GreeceValidated
Annual incidence1-9 / 1 000 0000.16HungaryValidated
Annual incidence1-9 / 1 000 0000.36IrelandValidated
Annual incidence1-9 / 1 000 0000.1ItalyValidated
Annual incidence1-9 / 1 000 0000.14LatviaValidated
Annual incidence1-9 / 1 000 0000.3LithuaniaValidated
Annual incidence<1 / 1 000 0000.04LuxembourgValidated
Annual incidence1-9 / 1 000 0000.42MaltaValidated
Annual incidence1-9 / 1 000 0000.36NetherlandsValidated

Signs & symptoms

Clinical features (HPO)

40 HPO clinical features (Orphanet curated; top 40 by frequency):

HPO IDTermFrequency
HP:0001873ThrombocytopeniaFrequent (30-79%)
HP:0001945FeverFrequent (30-79%)
HP:0002017Nausea and vomitingFrequent (30-79%)
HP:0002027Abdominal painFrequent (30-79%)
HP:0002039AnorexiaFrequent (30-79%)
HP:0002152HyperproteinemiaFrequent (30-79%)
HP:0002315HeadacheFrequent (30-79%)
HP:0002615HypotensionFrequent (30-79%)
HP:0002829ArthralgiaFrequent (30-79%)
HP:0003326MyalgiaFrequent (30-79%)
HP:0008150Elevated serum transaminases during infectionsFrequent (30-79%)
HP:0030953Conjunctival hyperemiaFrequent (30-79%)
HP:0000952JaundiceOccasional (5-29%)
HP:0000988Skin rashOccasional (5-29%)
HP:0001287MeningitisOccasional (5-29%)
HP:0001919Acute kidney injuryOccasional (5-29%)
HP:0002011Morphological central nervous system abnormalityOccasional (5-29%)
HP:0002014DiarrheaOccasional (5-29%)
HP:0002098Respiratory distressOccasional (5-29%)
HP:0002105HemoptysisOccasional (5-29%)
HP:0002202Pleural effusionOccasional (5-29%)
HP:0002240HepatomegalyOccasional (5-29%)
HP:0002716LymphadenopathyOccasional (5-29%)
HP:0011705First degree atrioventricular blockOccasional (5-29%)
HP:0012115HepatitisOccasional (5-29%)
HP:0012735CoughOccasional (5-29%)
HP:0025143ChillsOccasional (5-29%)
HP:0025439PharyngitisOccasional (5-29%)
HP:0031197Cellular urinary castsOccasional (5-29%)
HP:0040223Pulmonary hemorrhageOccasional (5-29%)
HP:0000554UveitisVery rare (<1-4%)
HP:0000573Retinal hemorrhageVery rare (<1-4%)
HP:0001085PapilledemaVery rare (<1-4%)
HP:0001701PericarditisVery rare (<1-4%)
HP:0003201RhabdomyolysisVery rare (<1-4%)
HP:0011675ArrhythmiaVery rare (<1-4%)
HP:0011896Subconjunctival hemorrhageVery rare (<1-4%)
HP:0012424ChorioretinitisVery rare (<1-4%)
HP:0030497Macular cotton wool spotVery rare (<1-4%)
HP:0100653Optic neuritisVery rare (<1-4%)

Identifiers

Disease identifiers

FieldValue
Canonical nameleptospirosis
Mondo IDMONDO:0005825
EFOEFO:0007344
MeSHD007922
Orphanet509
DOIDDOID:2297
ICD-10-CMA27
ICD-11751399056
NCITC84825
SNOMED CT77377001
UMLSC0023364
MedGen7309
GARD0007881
MedDRA10024238
NORD1363
Is cancer (heuristic)no

Also known as: cane-cutter fever · canicola fever · hemorrhagic jaundice · Icterohemorrhagic fever · Leptospira caused disease or disorder · Leptospira disease or disorder · Leptospira infectious disease · leptospirosis · mud fever · nanukayami fever · rice-field fever · Stuttgart disease · swamp fever · swineherd’s disease · Weil disease

Disease family

This is a subtype of primary bacterial infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › primary bacterial infectious disease › leptospirosis

Related subtypes (36): Buruli ulcer disease, sennetsu fever, salmonellosis, pinta disease, chancroid, gonorrhea, anthrax infection, leprosy, botulism, diphtheria, tetanus, bartonellosis, brucellosis, campylobacteriosis, glanders, granuloma inguinale, legionellosis, listeriosis, Mycobacterium avium complex disease, ornithosis, rhinoscleroma, staphyloenterotoxemia, syphilis, cholera, ehrlichiosis, melioidosis, tuberculosis, tularemia, plague, Q fever, shigellosis, Lyme disease, relapsing fever, spirillary rat-bite fever, streptobacillary rat-bite fever, Borrelia miyamotoi disease

Subtypes (1): Weil’s disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Desmopressin, Dexamethasone.

Clinical trials & evidence

Clinical trials

Clinical trials: 22.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified19
PHASE41
PHASE2/PHASE31
PHASE21

Top trials by phase / activity

NCTPhaseStatusTitle
NCT04211649PHASE4NOT_YET_RECRUITINGComparing Two Antibiotic Therapy Periods (3 Versus 7 Days) in Patients With Mild Leptospirosis and Seen at the Hospital in 5 French Overseas Departments (Martinique, Guadeloupe, French Guiana, Reunion, Mayotte)
NCT00592566PHASE2/PHASE3TERMINATEDDesmopressin and Dexamethasone Adjunctive Treatment for Leptospirosis
NCT07127718PHASE2RECRUITINGPreventive Strategies for Early and Late Complications of Leptospirosis
NCT04034550Not specifiedACTIVE_NOT_RECRUITINGCohort of Hospitalized Patients Suspected of Leptospirosis
NCT04288674Not specifiedRECRUITINGLeptospirosis Registry - LeptoScope
NCT05425524Not specifiedRECRUITINGLeptospirosis Care Bundle Study
NCT05436756Not specifiedRECRUITINGChronic Post-leptospirosis Manifestations in Reunion
NCT06859619Not specifiedNOT_YET_RECRUITINGSerological Measurement of Montpellier Professionals’ Contacts with Infectious Agents Responsible for Animal-borne Diseases
NCT06945822Not specifiedNOT_YET_RECRUITINGCharacterizing the Host Response to Leptospirosis for Better Diagnosis and Prognosis - NIHFI
NCT07358910Not specifiedRECRUITINGRisk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
NCT07520279Not specifiedENROLLING_BY_INVITATIONXpert® Tropical Fever Test on GeneXpert® Edge X System
NCT07611591Not specifiedNOT_YET_RECRUITINGEx Vivo Study of Leukocyte Responses in the Blood of Patients With Leptospirosis and ex Vivo Testing of a New Host-targeted Therapeutic Strategy to Restore Phagocytosis of Leptospira
NCT01080989Not specifiedCOMPLETEDThe Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands
NCT01607047Not specifiedUNKNOWNFrench West Indies Leptospirosis Study
NCT01766830Not specifiedCOMPLETEDRapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)
NCT02000635Not specifiedUNKNOWNStudy of Decreasing Kinetics of the Leptospiremia During Antibiotic Treatment of Leptospirosis in Martinique
NCT02898519Not specifiedUNKNOWNImmune Response After Leptospirosis Infection
NCT03497572Not specifiedCOMPLETEDSeroprevalence Study to Evaluate the Persistence of Anti-leptospira Antibody in Subjects Vaccinated With Spirolept® Vaccine
NCT03912506Not specifiedCOMPLETEDSevere Leptospirosis in Non-tropical Areas
NCT04882046Not specifiedUNKNOWNStudy of the Incidence of Jarisch-Herxheimer Reaction in Leptospirosis Patients in New Caledonia
NCT05300425Not specifiedCOMPLETEDSeroprevalence of Leptospirosis in Val Müstair, Switzerland
NCT05413720Not specifiedCOMPLETEDStudy of the Innate Immune Response to the Acute Phase of Human Leptospirosis - IMMUNOLEPTO

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
DESMOPRESSIN41
DEXAMETHASONE41

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 25

This page pulls from 25 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogardgenccgwasgwas_studyhgncicd10cmicd11meddramedgenmeshmimmondomondochildmondoparentncitnordorphanetsctidumls