Leukoplakia of penis

Summary

Leukoplakia of penis (MONDO:0006830) is a disease with 1 GWAS associations across 4 studies. A subtype of penile disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• GWAS associations: 1

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	leukoplakia of penis
Mondo ID	MONDO:0006830
DOID	DOID:8738
ICD-10-CM	N48.0
NCIT	C3151
SNOMED CT	3323003
UMLS	C0022782
MedGen	44036
MedDRA	10024394
Anatomy (UBERON)	UBERON:0000989
Is cancer (heuristic)	no

Also known as: kraurosis of penis · kraurosis penis · leukoplakia of the penis · penile leukoplakia

Data availability: 1 GWAS association (4 studies).

Disease family

This is a subtype of penile disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › male reproductive system disorder › penile disorder › leukoplakia of penis

Related subtypes (6): erectile dysfunction, balanitis, penile neoplasm, phimosis, posthitis, vascular disorder of penis

Genetics & variants

GWAS landscape

1 GWAS associations across 4 studies. Top hits map to 1 distinct genes (as reported by GWAS).

Top associations by p-value

rsID	p-value	Gene	Risk allele	Odds ratio
rs185326965	2e-11	SLC9A9	A	2.77

Top studies (by case count)

Study	Lead author	Year	Cases	Controls	Title
GCST90478640	Verma A	2024	3,269	412,428	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90478639	Verma A	2024	1,456	102,648	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90480416	Verma A	2024	1,456	102,648	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90478638	Verma A	2024	1,091	52,214	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

Tier	Variants
Tier 1: coding	0
Tier 2: splice/UTR	0
Tier 3: regulatory	0
Tier 4: intronic/intergenic	1

MAF distribution

Bucket	Variants
common (>=0.05)	0
low_freq (0.01-0.05)	0
rare (<0.01)	1
unknown	0

Functional consequences

Consequence	Count
intron_variant	1

Top variants

rsID	Chr	Pos	Alleles	MAF	Consequence	Gene	p-value	Tier
rs185326965	3	143519089	A>G	0	intron_variant	SLC9A9	2e-11	Tier 4: intronic/intergenic

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.