Leukoplakia

Summary

Leukoplakia (MONDO:0043243) is a disease (an umbrella term covering 5 Mondo subtypes) and 14 clinical trials. Top therapeutic interventions include ketorolac and methylcellulose. A subtype of precancerous condition — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 5 Mondo subtypes
• Clinical trials: 14

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	leukoplakia
Mondo ID	MONDO:0043243
MeSH	D007971
NCIT	C3186
SNOMED CT	274134003
UMLS	C0023531
MedGen	44133
Anatomy (UBERON)	UBERON:0000344
Is cancer (heuristic)	no

Also known as: keratotic plaque · lesion, leukoplakic · lesions, leukoplakic · leukokeratoses · leukokeratosis · leukoplakia · leukoplakias · leukoplakic lesion · leukoplakic lesions

Disease family

This is a subtype of precancerous condition. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › precancerous condition › leukoplakia

Related subtypes (7): pre-malignant neoplasm, in situ carcinoma, neoplastic polyp, intraepithelial neoplasia, premalignant hematological system disease, gastric intestinal metaplasia, preneoplastic lesion

Subtypes (5): leukoplakia of vagina, esophageal leukoplakia, uterine cervix leukoplakia, oral mucosa leukoplakia, leukoplakia of penis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 14.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	7
PHASE2	3
PHASE1/PHASE2	2
PHASE3	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01497951	PHASE3	COMPLETED	Photodynamic Therapy for Oral Precursor Lesions
NCT03603223	PHASE2	RECRUITING	Pembrolizumab in Treating Participants With Leukoplakia
NCT07210775	PHASE1/PHASE2	RECRUITING	Topical Imiquimod Treatment of Oral Dysplasia
NCT00001698	PHASE2	COMPLETED	Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCR
NCT00571974	PHASE1/PHASE2	COMPLETED	Treatment of Oral Premalignant Lesions With 5-ALA PDT
NCT03990636	PHASE2	UNKNOWN	Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - Phase 2 Clinical Trial
NCT05536037	PHASE1	TERMINATED	Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions
NCT05323292	Not specified	ENROLLING_BY_INVITATION	Vitamin A Status in Patients With Vocal Fold Leukoplakia
NCT07596355	Not specified	NOT_YET_RECRUITING	AI-Assisted Endoscopy for Upper Aerodigestive Tract Lesions
NCT00179361	Not specified	COMPLETED	Natural History of Oro-pharyngeal Cancer Precursors
NCT02737176	Not specified	UNKNOWN	Tobacco Cessation Intervention Study for Oral Diseases
NCT03233165	Not specified	COMPLETED	Comparison Between Two Different High Power Ablative Lasers in the Treatment of Oral Leukoplakia
NCT04267419	Not specified	COMPLETED	Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions
NCT06325514	Not specified	COMPLETED	Artificial Intelligence Based Program to Classify Oral Cavity Findings Based on Clinical Image Analysis

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
KETOROLAC	4	1
METHYLCELLULOSE	4	1