Lichen planus, oral

Summary

Lichen planus, oral (MONDO:0043923) is a disease and 127 clinical trials. Top therapeutic interventions include clobetasol propionate, betamethasone, and triamcinolone acetonide. A subtype of lichen planus — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 127

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	lichen planus, oral
Mondo ID	MONDO:0043923
MeSH	D017676
NCIT	C7406
SNOMED CT	235049008
UMLS	C0206139
MedGen	60084
Is cancer (heuristic)	no

Also known as: oral lichen planus

Disease family

This is a subtype of lichen planus. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › integumentary system disorder › skin disorder › dermatitis › lichen planus › lichen planus, oral

Related subtypes (10): lichen planus, familial, linear lichen planus, actinic lichen planus, annular atrophic lichen planus, annular lichen planus, atrophic lichen planus, lichen planus pigmentosus, lichen planus pemphigoides, bullous lichen planus, hypertrophic lichen planus

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 7 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Betamethasone	Phase 3 (in late-stage trials)
Dexamethasone	Phase 3 (in late-stage trials)
Epigalocatechin Gallate	Phase 3 (in late-stage trials)
Epoetin Beta	Phase 3 (in late-stage trials)
Minocycline	Phase 3 (in late-stage trials)
Sirolimus	Phase 3 (in late-stage trials)
Triamcinolone Acetonide	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Apremilast, Betamethasone Dipropionate, Bifidobacterium Spp., Clobetasol, Clobetasol Propionate, Curcumin, Licorice, Metronidazole, OMEGA-3-ACID ETHYL ESTERS, Pimecrolimus, Prednisone, Tacrolimus Anhydrous, Triamcinolone.

Clinical trials & evidence

Clinical trials

Clinical trials: 127.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	62
PHASE2	26
PHASE4	15
PHASE3	9
PHASE1	6
EARLY_PHASE1	5
PHASE2/PHASE3	2
PHASE1/PHASE2	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07100145	PHASE4	NOT_YET_RECRUITING	Efficacy of Coconut Gel Compared to Corticosteroid Gel in the Management of Oral Lichen Planus
NCT07131813	PHASE4	RECRUITING	Evaluation of Efficacy and Safety of add-on Tofacitinib in Patients With Oral Lichen Planus
NCT07280442	PHASE4	NOT_YET_RECRUITING	Effectiveness of a Sodium Hyaluronate 0.01% and Sh-Oligopeptide-85 SP Mouthwash for the Treatment of Symptomatic Oral Lichen Planus
NCT02443311	PHASE4	COMPLETED	Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus
NCT02587117	PHASE4	COMPLETED	A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus
NCT02858297	PHASE4	COMPLETED	Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus
NCT03572959	PHASE4	COMPLETED	Management of Pain in Oral Lichen Planus
NCT04193748	PHASE4	COMPLETED	Evaluation of Topical Pomegranate Extracts in Management of Oral Lichen Planus (A Randomized Clinical Trial)
NCT04278599	PHASE4	UNKNOWN	Effect of Oral Zinc Supplementation as an Adjuvant to Topical Corticosteroid in Oral Lichen Planus Patients
NCT05139667	PHASE4	COMPLETED	Evaluation of Mucoadhesive Tacrolimus Patch on Caspase-3 Inducing Apoptosis in Oral Lichen Planus
NCT05882864	PHASE4	UNKNOWN	Efficacy of Ginger Muco-bioadhesive Gel in Management of Oral Lichen Planus With Immunohistochemical Analysis
NCT06204796	PHASE4	COMPLETED	The Role of Vitamin D in Amelioration of Oral Lichen Planus and Its Effect on Salivary IFN-γ Level
NCT06260904	PHASE4	COMPLETED	Efficacy and Safety of add-on Apremilast Versus add-on Methotrexate in Patients With Oral Lichen Planus
NCT06362005	PHASE4	COMPLETED	The Efficacy of Selenium as an Alternative or Complementary Topical Treatment of Oral Lichen Planus
NCT07114016	PHASE4	COMPLETED	Efficacy of Topical Glucosamine Versus Corticosteroid in Oral Lichen Planus
NCT04364555	PHASE2/PHASE3	ACTIVE_NOT_RECRUITING	Efficacy of Topical Treatment With Clobetasol in Symptomatic Oral Lichen Planus.
NCT06060301	PHASE3	ACTIVE_NOT_RECRUITING	Topical Sulfasalazine and Oral Lichen Planus
NCT00130572	PHASE3	COMPLETED	Efficacy of Elidel Cream on Erosive Oral Lichen Planus
NCT01061853	PHASE3	TERMINATED	Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen
NCT01083420	PHASE3	UNKNOWN	The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus
NCT02329600	PHASE3	COMPLETED	Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus
NCT02421770	PHASE3	COMPLETED	Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus
NCT03509675	PHASE2/PHASE3	COMPLETED	Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions.
NCT06119672	PHASE3	UNKNOWN	Efficacy of Probiotic Capsules With Topical Clobetasol Propionate in OLP Treatment
NCT06135259	PHASE3	UNKNOWN	Topical Erythropoietin Hydrogel in Management of Oral Lichen Planus
NCT06605911	PHASE3	COMPLETED	Assessment of the Efficacy of Topical Curcumin in Treatment of Oral Lichen Planus
NCT06158113	PHASE2	ACTIVE_NOT_RECRUITING	Efficacy and Safety of Baricitinib in Oral Lichen Planus: a Proof-of-Concept Study
NCT06233591	PHASE2	ACTIVE_NOT_RECRUITING	Evaluating LP-10 in Subjects With OLP
NCT06810752	PHASE1/PHASE2	ENROLLING_BY_INVITATION	Thyme Honey for Management of Oral Lichen Planus
NCT06876038	PHASE2	NOT_YET_RECRUITING	Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions
NCT06981767	PHASE2	RECRUITING	Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus
NCT07100613	PHASE2	RECRUITING	Mucoadhesive Modified-Release Formulations for the Topical Treatment of Symptomatic Oral Lichen Planus
NCT00102557	PHASE2	COMPLETED	Hydroxychloroquine vs. Clobetasol Rinse to Treat Oral Lichen Planus
NCT00111072	PHASE2	COMPLETED	Dexamethasone to Treat Oral Lichen Planus
NCT00226174	PHASE2	TERMINATED	A Randomized, Placebo-controlled, Double-blind Clinical Trial of Curcuminoids in Oral Lichen Planus
NCT00297037	PHASE2	COMPLETED	Pimecrolimus Cream for Oral Lichen Planus
NCT00484250	PHASE2	COMPLETED	Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other
NCT00525421	PHASE2	COMPLETED	A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus
NCT00656214	PHASE2	COMPLETED	Treatmant of Oral Lichen Planus With Lycopene
NCT00746772	PHASE2	COMPLETED	Efficacy of Purslane in Treatment of Oral Lichen Planus

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CLOBETASOL PROPIONATE	4	9
BETAMETHASONE	4	7
TRIAMCINOLONE ACETONIDE	4	6
PIMECROLIMUS	4	4
ROSE BENGAL FREE ACID	4	2
APREMILAST	4	1
BARICITINIB	4	1
BETAMETHASONE DIPROPIONATE	4	1
BROMELAINS	4	1
EFALIZUMAB	4	1
FLUOCINOLONE ACETONIDE	4	1
FLUOCINONIDE	4	1
GLUCOSAMINE HYDROCHLORIDE	4	1
GLUCOSAMINE SULFATE	4	1
HYALURONIC ACID	4	1
MINOCYCLINE	4	1
NYSTATIN	4	1
PREDNISOLONE	4	1
SULFASALAZINE	4	1
TRIAMCINOLONE	4	1
CLOBETASOL	3	3
LYCOPENE	3	2
CARBOXYMETHYLCELLULOSE SODIUM	3	1
CHAMOMILE	3	1
CURCUMIN	3	1
HONEY	3	1
LICORICE	3	1
SELENIUM	3	1
SESAME OIL	3	1
WAX, EMULSIFYING	3	1