Limb ischemia
disease diseaseOn this page
Also known as ischaemic disease of limbischemic disease of limblimb ischaemic diseaselimb ischemic disease
Summary
Limb ischemia (MONDO:0000491) is a disease and 33 clinical trials. Top therapeutic interventions include sodium chloride, acetylcholine, and vepoloxamer. A subtype of ischemic disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 33
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | limb ischemia |
| Mondo ID | MONDO:0000491 |
| DOID | DOID:0050852 |
| SNOMED CT | 21631000119105 |
| UMLS | C2945695 |
| MedGen | 754513 |
| Anatomy (UBERON) | UBERON:0002101 |
| Is cancer (heuristic) | no |
Also known as: ischaemic disease of limb · ischemic disease of limb · limb ischaemic disease · limb ischemia · limb ischemic disease
Disease family
This is a subtype of ischemic disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › ischemic disease › limb ischemia
Related subtypes (5): retinal ischemia, brain ischemia, ischemic bowel disorder, myocardial ischemia, peripheral ischemia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 33.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 26 |
| PHASE2 | 5 |
| PHASE3 | 1 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05372718 | PHASE3 | RECRUITING | Thrombolysis With Recombinant Non-immunogenic Staphylokinase vs Surgery in Patients With Acute Limb Ischemia FORAT Trial |
| NCT00453531 | PHASE1/PHASE2 | COMPLETED | Model System for Transient Forearm Blood Vessel Dysfunction |
| NCT02093468 | PHASE2 | TERMINATED | Evaluation of MST-188 in Acute Lower Limb Ischemia |
| NCT02479555 | PHASE2 | UNKNOWN | Lower-Limb Adventitial Infusion of DexaMethasone Via Bullfrog to Reduce Occurrence of Restenosis After Percutaneous Transluminal Angioplasty Revascularization |
| NCT02479620 | PHASE2 | UNKNOWN | Lower-Limb Adventitial Infusion of DexaMethasone Via Bullfrog to Reduce Occurrence of Restenosis After Atherectomy (ATX)-Based Revascularization |
| NCT02908035 | PHASE2 | UNKNOWN | Temsirolimus Adventitial Delivery to Improve Angiographic Outcomes Below the Knee (TANGO) |
| NCT04466007 | PHASE2 | COMPLETED | Safety and Efficacy of Allogeneic Adipose Tissue Mesenchymal Stem Cells in Diabetic Patients With Critical Limb Ischemia |
| NCT05830721 | Not specified | RECRUITING | Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients |
| NCT05868161 | Not specified | RECRUITING | Pounce™ Thrombectomy System Retrospective Registry |
| NCT06416644 | Not specified | ACTIVE_NOT_RECRUITING | The PORTuguese Registry of Supera Supported Femoral-Fopliteal Revascularization (SupPORT Registry) |
| NCT06882187 | Not specified | NOT_YET_RECRUITING | ALI in Cancer Patients |
| NCT07335341 | Not specified | RECRUITING | Case-Specific Health Care Professional Clinical Survey of Liberant™ Thrombectomy System |
| NCT07387653 | Not specified | RECRUITING | Feasibility and Clinical Utility of Paired Non-Invasive Hemodynamic and Tissue Oximetry Monitoring to Detect Limb Ischemia in Lithotomy-Positioned Surgeries |
| NCT07482865 | Not specified | NOT_YET_RECRUITING | Routine Versus Provisional Distal Perfusion Catheter Placement in Patients Undergoing Mechanical Circulatory Support |
| NCT00730561 | Not specified | COMPLETED | Hematopoietic Stem Cell Transplantation for the Treatment of Limb Ischemia and Diabetic Neuropathy |
| NCT00768495 | Not specified | UNKNOWN | Hyperspectral Imaging Pre and Post Endovascular Intervention |
| NCT03040063 | Not specified | UNKNOWN | Complex Endovascular Approach to Treatment of Patients With Aneurysm of Popliteal Artery |
| NCT03294902 | Not specified | COMPLETED | Improving Radiological Outcomes in Arterial Disease - A Pilot Evaluation of the Pedra Tissue Perfusion Monitoring System |
| NCT03388021 | Not specified | COMPLETED | A Trial Comparing Routine Versus Selective Use of Completion Angiography After Surgical Thromboembolectomy in the Treatment of Acute Lower Limb Ischemia and Their Impacts on Limb Salvage Rates |
| NCT03847597 | Not specified | UNKNOWN | Histological and Imaging Assessment of the Structural Characteristics of the Femoro-popliteal Arterial Segment |
| NCT04016857 | Not specified | COMPLETED | Remote Ischemic Preconditioning During Lower Limb Revascularization |
| NCT04066387 | Not specified | COMPLETED | Characteristics and Prognosis of Patients With Critical Ischemia at High Risk of Amputation Managed by Endovascular Bypass: a Retrospective Study of 15 Patients |
| NCT04343196 | Not specified | COMPLETED | Digital Variance Angiography in Diagnostic Angiographies for Effective Radiation Dose Reduction |
| NCT04622878 | Not specified | UNKNOWN | Combined Management in ALI ( Image Guided Thrombectomy With Open Transfemoral Access ) |
| NCT05138679 | Not specified | COMPLETED | Evaluation of Acute Lower Limb Ischemia |
| NCT05410548 | Not specified | COMPLETED | Comorbidity Screening and Referral by Prosthetists |
| NCT05411315 | Not specified | COMPLETED | Pragmatic Randomized Trial for Arterial Catheters in the Critical Care Environment |
| NCT06050499 | Not specified | UNKNOWN | Chemical Analysis of Limb Microfluidics |
| NCT06222658 | Not specified | UNKNOWN | The Role of Pharmaco-mechanical Thrombectomy in Management of Acute Lower Extremity Arterial Ischemia |
| NCT06229015 | Not specified | COMPLETED | Evaluation of Online Tool (E-TOOL SCS) in Spinal Cord Stimulaion |
| NCT06357936 | Not specified | UNKNOWN | Nanofat Grafting as a Method of Treating Critical Limb Ischemia |
| NCT06446024 | Not specified | COMPLETED | Post Market Surveillance to Evaluate the Efficacy and Safety of the INDIGO Aspiration System in Japan |
| NCT07066371 | Not specified | COMPLETED | The Effect of Emotional Freedom Technique on Patients Receiving Preventive Foot Care |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| SODIUM CHLORIDE | 4 | 2 |
| ACETYLCHOLINE | 4 | 1 |
| VEPOLOXAMER | 3 | 1 |
Related Atlas pages
- Drugs: Sodium Chloride, Acetylcholine, Vepoloxamer