Lip cancer
diseaseOn this page
Also known as cancer of lipmalignant Lip neoplasmmalignant Lip tumormalignant Lip tumourmalignant neoplasm of Lipmalignant neoplasm of lip, inner aspectmalignant neoplasm of lip, unspecifiedmalignant neoplasm of lip, unspecified, inner aspectmalignant neoplasm of lip, unspecified, vermilion bordermalignant neoplasm of oral aspect of lip, not specified whether upper or lowermalignant neoplasm of the Lipmalignant tumor of commissure of lipmalignant tumor of labial commissuremalignant tumor of Lipmalignant tumor of the Lipmalignant tumour of commissure of lipmalignant tumour of labial mucosamalignant tumour of Lipmalignant tumour of lower labial mucosa
Summary
Lip cancer (MONDO:0006834) is a cancer and 9 clinical trials. Top therapeutic interventions include cisplatin and trastuzumab botidotin. A subtype of oral cavity cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 9
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | lip cancer |
| Mondo ID | MONDO:0006834 |
| EFO | EFO:1001019 |
| MeSH | D008048 |
| DOID | DOID:8564 |
| ICD-10-CM | C00 |
| ICD-11 | 304997495 |
| NCIT | C7485 |
| SNOMED CT | 187622006 |
| UMLS | C0153340 |
| MedGen | 57548 |
| GARD | 0027767 |
| MedDRA | 10007089 |
| Anatomy (UBERON) | UBERON:0001833 |
| Is cancer (heuristic) | yes |
Also known as: cancer of lip · lip cancer · malignant Lip neoplasm · malignant lip neoplasm · malignant Lip tumor · malignant Lip tumour · malignant neoplasm of Lip · malignant neoplasm of lip · malignant neoplasm of lip, inner aspect · malignant neoplasm of lip, unspecified · malignant neoplasm of lip, unspecified, inner aspect · malignant neoplasm of lip, unspecified, vermilion border · malignant neoplasm of oral aspect of lip, not specified whether upper or lower · malignant neoplasm of the Lip · malignant tumor of commissure of lip · malignant tumor of labial commissure · malignant tumor of Lip · malignant tumor of lip · malignant tumor of the Lip · malignant tumour of commissure of lip (+5 more)
Disease family
This is a subtype of oral cavity cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › digestive system cancer › oral cavity cancer › lip cancer
Related subtypes (10): soft palate cancer, tongue cancer, cheek mucosa cancer, salivary gland cancer, retromolar area cancer, hard palate cancer, vestibule of mouth cancer, gingival cancer, oral cavity carcinoma, oral rhabdomyosarcoma
Subtypes (3): upper lip cancer, lower lip cancer, carcinoma of lip
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 9.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 7 |
| PHASE2 | 1 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT03174275 | PHASE2 | ACTIVE_NOT_RECRUITING | Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma |
| NCT03602079 | PHASE1/PHASE2 | COMPLETED | Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene |
| NCT00568490 | Not specified | RECRUITING | Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers |
| NCT02012699 | Not specified | RECRUITING | Integrated Cancer Repository for Cancer Research |
| NCT05837221 | Not specified | RECRUITING | Microbiome in Head and Neck Squamous Cell Carcinoma |
| NCT00186433 | Not specified | COMPLETED | A Longitudinal Study of Plasma EBV DNA in Nasopharyngeal Carcinoma From Both Endemic and Non-Endemic Patient Populations |
| NCT01084733 | Not specified | COMPLETED | Nicotine Levels With Response Rates to Radiation Alone or With Chemo In Head & Neck Cancer |
| NCT05610293 | Not specified | UNKNOWN | T1 Squamous Cell Carcinomas of the Lip |
| NCT07005115 | Not specified | COMPLETED | Serum Lipid Profile and Lip Squamous Cell Carcinoma |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CISPLATIN | 4 | 1 |
| TRASTUZUMAB BOTIDOTIN | 2 | 1 |
Related Atlas pages
- Drugs: Cisplatin