Lipedema
disease diseaseOn this page
Also known as Lipedema (disease)
Summary
Lipedema (MONDO:0013577) is a disease and 59 clinical trials. Top therapeutic interventions include ozone and utenpanium chloride. A subtype of subcutaneous tissue disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- ClinVar variants: 1
- Clinical trials: 59
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | Lipedema |
| Mondo ID | MONDO:0013577 |
| MeSH | D065134 |
| OMIM | 614103 |
| Orphanet | 77243 |
| SNOMED CT | 234102003 |
| UMLS | C0398370 |
| MedGen | 451048 |
| MedDRA | 10063955 |
| Is cancer (heuristic) | no |
Also known as: lipedema · Lipedema (disease)
Data availability: 1 ClinVar variant · 1 HPO phenotype.
Disease family
This is a subtype of subcutaneous tissue disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › integumentary system disorder › subcutaneous tissue disorder › Lipedema
Related subtypes (18): nodular fasciitis, hemangioma of subcutaneous tissue, adiposis dolorosa, isolated anhidrosis with normal sweat glands, fibrodysplasia ossificans progressiva, multiple symmetric lipomatosis, familial multiple lipomatosis, familial angiolipomatosis, cerebrotendinous xanthomatosis, dissecting cellulitis of the scalp, Pierpont syndrome, CLOVES syndrome, encephalocraniocutaneous lipomatosis, FLOTCH syndrome, mycetoma, nodular non-suppurative panniculitis, Roch-Leri mesosomatous lipomatosis, cytophagic histiocytic panniculitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
ClinVar germline variants
1 retrieved; paginated sample, class counts are floors:
1 pathogenic
| ClinVar | Variant (HGVS) | Gene | Classification | Review |
|---|---|---|---|---|
| 267923 | 46;XX;t(10;15)(q25.2;q11.2) | Pathogenic | criteria provided, single submitter |
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 59.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 58 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT03492840 | PHASE2 | COMPLETED | Treatment of Women With Lipedema Involving Substantial Fat Knee of Women and Men With Nodular Dercum’s Disease |
| NCT00833599 | Not specified | ENROLLING_BY_INVITATION | Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders |
| NCT04272827 | Not specified | ACTIVE_NOT_RECRUITING | Evaluation Between Surgical Therapy of Lipedema Compared to Complex Physical Decongestive Therapy (CDT) Alone |
| NCT04632810 | Not specified | ACTIVE_NOT_RECRUITING | Effect of Ketosis on Pain and Quality of Life in Patients With Lipedema |
| NCT05284266 | Not specified | ACTIVE_NOT_RECRUITING | The National Lipedema Study |
| NCT05464927 | Not specified | ACTIVE_NOT_RECRUITING | Visualizing Vascular Mechanisms of Lipedema |
| NCT05628948 | Not specified | RECRUITING | Vascular Lab Resource (VLR) Biorepository |
| NCT05739279 | Not specified | RECRUITING | Sarcopenia and Related Factors in Lipedema |
| NCT06180850 | Not specified | ACTIVE_NOT_RECRUITING | Building Lipedema Research Resources |
| NCT06399367 | Not specified | ENROLLING_BY_INVITATION | Investigation of Lipedema, Lymphedema and Vascular Malformations by Multispectral Optoacoustic Tomography (MSOT) |
| NCT06558851 | Not specified | ACTIVE_NOT_RECRUITING | The Effect of Systematic Endurance Training in Treatment of Women With Lipedema |
| NCT06695403 | Not specified | ACTIVE_NOT_RECRUITING | Telerehabilitation Versus Supervised Pilates Training in Lipedema Women |
| NCT06770634 | Not specified | RECRUITING | Investigation of Central Sensitization and Associated Factors in Patients With Lipedema |
| NCT06811961 | Not specified | RECRUITING | Effects of Exercise in Patients with Lipedema |
| NCT06964828 | Not specified | RECRUITING | Proof of Concept, Randomized, and Crossover Study, to Assess the Effectiveness of Two Types of Compression Garments in Lipedema |
| NCT07240415 | Not specified | NOT_YET_RECRUITING | ESWT for Primary Lipedema |
| NCT07294014 | Not specified | RECRUITING | Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema |
| NCT07319611 | Not specified | NOT_YET_RECRUITING | Investigation of the Effects of High-Intensity Interval Exercise and Moderate-Intensity Continuous Exercise on Limb Volume, Functional Capacity, and Quality of Life in Patients With Lipedema |
| NCT07404059 | Not specified | AVAILABLE | Effect of Ultrasound Cavitation Versus Pneumatic Compression on Adipose Tissue Thickness on Lipedema Patients |
| NCT07468097 | Not specified | RECRUITING | The Impact of Metabolic Status on Pain and Central Sensitization in Women With Lipedema: A Cross-Sectional Observational Study |
| NCT07489248 | Not specified | RECRUITING | Multimodal Ultrasound for Differentiating Lymphedema and Lipedema |
| NCT07575555 | Not specified | NOT_YET_RECRUITING | The Effect of Lipedema on Knee Osteoarthritis |
| NCT07603076 | Not specified | NOT_YET_RECRUITING | Assessment of Venous Insufficiency and Clinical Features in Lipedema |
| NCT02838277 | Not specified | UNKNOWN | Insight Into Subcutaneous Adipose Tissue Disorders |
| NCT02907411 | Not specified | COMPLETED | Quadrivas Therapy® to Reduce Lipedema Subcutaneous Adipose Tissue (QUADRIVAS) |
| NCT03271034 | Not specified | COMPLETED | Effect of Weight Loss on Body Composition and Metabolic Function in Women With Lipedema |
| NCT03634462 | Not specified | COMPLETED | Complete Decongestive Therapy With Negative Pressure for Lipedema and Lymphedema Therapy |
| NCT03710798 | Not specified | COMPLETED | Effect of an Low Carbon High Fat Diet on Pain- and Quality of Life in Patients With Lipedema |
| NCT03758651 | Not specified | COMPLETED | Williams Syndrome Strength, Hormones, Activity & Adiposity, DNA Programming, Eating Study |
| NCT03853083 | Not specified | UNKNOWN | HYPOXI for Women With Lipedema |
| NCT03924999 | Not specified | COMPLETED | Comparison of Complete Decongestive Therapy With Intermittent Pneumatic Compression for Treatment of Lipedema |
| NCT04166084 | Not specified | UNKNOWN | Trunk Stabilization Exercises at Lipoedema Patients |
| NCT04213989 | Not specified | COMPLETED | Intermittent Pneumatic Compression in Women With Lipo-lymphedema (Lipedema With Swelling) |
| NCT04492046 | Not specified | COMPLETED | Complex Decongestive Applications in Patients With Lipedema |
| NCT04643392 | Not specified | COMPLETED | Physiotherapy Applications in Upper Extremity Lipedema |
| NCT05114317 | Not specified | UNKNOWN | Characteristics of Pain in Women With Lipoedema |
| NCT05329324 | Not specified | COMPLETED | Is The Pain in Lipedema Patients Neuropathic Pain? |
| NCT05394467 | Not specified | COMPLETED | Adipose Cellular Kinetics of Lipedema |
| NCT05488977 | Not specified | COMPLETED | The Effects of Endurance Training on Lipedema |
| NCT05616962 | Not specified | COMPLETED | Vasculera in Participants With Lipedema |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| OZONE | 3 | 1 |
| UTENPANIUM CHLORIDE | 2 | 1 |
Related Atlas pages
- Drugs: Ozone