Liver and intrahepatic bile duct neoplasm

Summary

Liver and intrahepatic bile duct neoplasm (MONDO:0024477) is a cancer (an umbrella term covering 17 Mondo subtypes) and 246 clinical trials. Top therapeutic interventions include talaporfin, irinotecan, and sorafenib. A subtype of endocrine gland neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 17 Mondo subtypes
• Clinical trials: 246

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	liver and intrahepatic bile duct neoplasm
Mondo ID	MONDO:0024477
DOID	DOID:916
NCIT	C7103, C7106
SNOMED CT	126851005
UMLS	C1333976
MedGen	232599
Anatomy (UBERON)	UBERON:0002107
Is cancer (heuristic)	yes

Also known as: epithelial hepatic and intrahepatic bile duct neoplasm · hepatic and intrahepatic bile duct neoplasm · liver and intrahepatic bile duct epithelial neoplasm · liver and intrahepatic bile duct neoplasm · liver neoplasm · liver neoplasm (disease) · liver tumor · liver tumour · neoplasm of liver · tumor of liver · tumour of liver

Data availability: 24 cell lines.

Disease family

This is a subtype of endocrine gland neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › endocrine gland neoplasm › liver and intrahepatic bile duct neoplasm

Related subtypes (13): benign endocrine neoplasm, thymus neoplasm, granulosa cell tumor, thyroid tumor, pituitary tumor, familial tumoral calcinosis, neuroendocrine neoplasm, malignant endocrine neoplasm, non-functioning endocrine neoplasm, functioning endocrine neoplasm, adrenal gland neoplasm, pineal body neoplasm, tumor of parathyroid gland

Subtypes (17): liver lipoma, liver hemangioma, hepatic angiomyolipoma, liver cancer, liver solitary fibrous tumor, liver leiomyoma, liver inflammatory myofibroblastic tumor, biliary tract neoplasm, hepatic granuloma, solitary necrotic nodule of the liver, undifferentiated embryonal sarcoma of the liver, liver mesenchymal hamartoma, hepatocellular adenoma, inflammatory pseudotumor of the liver, fibrohistiocytic inflammatory pseudotumor of the liver, lymphoplasmacytic inflammatory pseudotumor of the liver, liver adenomatosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 246.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	147
PHASE2	37
PHASE1	21
PHASE1/PHASE2	18
PHASE3	11
PHASE4	9
EARLY_PHASE1	2
PHASE2/PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00152607	PHASE4	TERMINATED	Orthotopic Liver Transplantation Using a Living Donor
NCT00222664	PHASE4	COMPLETED	Qidong Hepatitis B Intervention Study
NCT00510627	PHASE4	WITHDRAWN	Study Comparing Radio Frequency Ablation Plus Chemotherapy and Chemotherapy Alone in Patients With Secondary Liver Metastases
NCT01564810	PHASE4	UNKNOWN	Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer
NCT01782573	PHASE4	COMPLETED	The Efficacy of Chlorhexidine Gluconate Pre - Disinfection Scrubbing in Preventing Surgical Site Infections for Hepatectomy Patients
NCT01819961	PHASE4	UNKNOWN	Parenteral Fish Oil in Major Laparoscopic Abdominal Surgery
NCT01972503	PHASE4	UNKNOWN	Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer
NCT05068180	PHASE4	UNKNOWN	Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients
NCT05848947	PHASE4	COMPLETED	SIR-Spheres Study to Calculate the Radiation-Absorbed Dose of 99mTc-MAA
NCT06555003	PHASE3	RECRUITING	DEBIRI Plus Chemotherapy vs. Chemotherapy Alone in Colorectal Cancer Liver Metastases
NCT00051545	PHASE3	TERMINATED	Seocalcitol Versus Placebo in the Adjuvant Treatment of Hepatocellular Carcinoma
NCT00143403	PHASE3	COMPLETED	Comparing Irinotecan and 5 FU/FA To 5-FU/FA After Resection Of Liver Metastases For Colorectal Cancer
NCT00355355	PHASE3	COMPLETED	A Phase 3 Study of Talaporfin Sodium and Interstitial Light Emitting Diodes Treating Hepatocellular Carcinoma (HCC)
NCT00470340	PHASE3	TERMINATED	Chemotherapy or Not, Following Complete Treatment of Hepatic Cancer in Cirrhotic Patients
NCT00788697	PHASE3	COMPLETED	SonoVue®-Enhanced Ultrasound Versus Unenhanced US for Focal Liver Lesion Characterization
NCT00829413	PHASE3	COMPLETED	SonoVue®-Enhanced Ultrasound (US) Versus Unenhanced US for Focal Liver Lesion Characterization
NCT01009593	PHASE3	TERMINATED	Efficacy and Tolerability of ABT-869 Versus Sorafenib in Advanced Hepatocellular Carcinoma (HCC)
NCT01214343	PHASE3	UNKNOWN	Comparing Efficacy of Sorafenib Versus Sorafenib in Combination With Low-dose FP in Patients With Advanced HCC
NCT01307878	PHASE3	COMPLETED	New Adjuvant Chemotherapy of Asymptomatic Resectable Primary Lesion With Unresectable Liver-limited Metastases
NCT01436721	PHASE2/PHASE3	UNKNOWN	Use of an Oxidized Regenerated Cellulose After Hepatic Surgery
NCT02192671	PHASE3	UNKNOWN	HR Versus RFA for HCC in Patients With PHT
NCT04008797	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING	A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor
NCT04634357	PHASE1/PHASE2	RECRUITING	ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma
NCT04864054	PHASE1/PHASE2	RECRUITING	T-Cell Therapy (ECT204) in Adults With Advanced HCC
NCT04982653	PHASE2	RECRUITING	Short Stitch Versus Traditional Suture for the Prevention of Incisional Hernia After Open Hepatectomy
NCT06261814	PHASE2	RECRUITING	Contrast Enhanced Ultrasound to Evaluate Response to Chemoembolization in Patients With Liver Tumors
NCT07145801	PHASE2	RECRUITING	Y-90 Treatment Response Using Transarterial Radioembolization
NCT07225114	PHASE2	RECRUITING	Translation of Acoustic Angiography: Contrast Enhanced Super Resolution (CESR) Imaging
NCT07227012	PHASE1/PHASE2	RECRUITING	Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.
NCT07243951	PHASE2	NOT_YET_RECRUITING	Phase II Clinical Study on the Efficacy and Safety of the Combination of Cadonilimab and Capecitabine in Adjuvant Therapy for Combined Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
NCT07246668	PHASE2	RECRUITING	A Phase II Single-Arm Clinical Study to Evaluate the Efficacy and Safety of Carbon Ion Radiotherapy With Atezolizumab and Bevacizumab Combination Therapy in Patients With Advanced Hepatocellular Carcinoma
NCT00041808	PHASE1/PHASE2	COMPLETED	Magnetic-Targeted Doxorubicin in Treating Patients With Cancer Metastatic to the Liver
NCT00068068	PHASE2	COMPLETED	Photodynamic Therapy With Talaporfin Sodium (LS11) in Treating Patients With Refractory Colorectal Liver Metastases
NCT00083785	PHASE2	COMPLETED	Study of the Litx™ System Combined With Chemotherapy in Patients With Colorectal Liver Metastases
NCT00106054	PHASE2	TERMINATED	Neoadjuvant Colorectal Cancer With Unresectable Liver Metastases
NCT00122876	PHASE1/PHASE2	COMPLETED	Tumor Ablation With Talaporfin Sodium and Interstitial Light Emitting Diodes Treating Hepatocellular Carcinoma (HCC)
NCT00145665	PHASE1/PHASE2	TERMINATED	The Role of Fluorothymidine Positron Emission Tomography (FLT-PET) in Proliferation of Colorectal Liver Metastases
NCT00149396	PHASE1/PHASE2	COMPLETED	Safety & Efficacy of NV1020 in Colorectal Cancer Metastatic to the Liver
NCT00152906	PHASE1/PHASE2	COMPLETED	Stereotactic Radiotherapy (SRT) Liver (COLD 1)
NCT00178243	PHASE1/PHASE2	COMPLETED	Feasibility of Treatment of Cancer Involving the Liver With High Dose Radiation

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
TALAPORFIN	4	6
IRINOTECAN	4	3
SORAFENIB	4	3
FLOXURIDINE	4	2
MELPHALAN	4	2
OXALIPLATIN	4	2
ADENOSINE	4	1
CETUXIMAB	4	1
CHLORHEXIDINE GLUCONATE	4	1
CHLOROTRIANISENE	4	1
ETHIODIZED OIL	4	1
FERUMOXYTOL	4	1
FLUOROURACIL	4	1
GEMCITABINE	4	1
LEUCOVORIN	4	1
SULFUR HEXAFLUORIDE	4	1
SUNITINIB	4	1
TALIMOGENE LAHERPAREPVEC	4	1
SEOCALCITOL	3	2
LINIFANIB	3	1
PERFLUBUTANE	3	1
TIGATUZUMAB	3	1
TYPHOID VI POLYSACCHARIDE VACCINE	3	1
FLUOROMISONIDAZOLE	2	1
GADOLINIUM	2	1
E-7386	1	1
H3B-6527	1	1
PF-06952229	1	1
CHEMBL1628	0	1
CHEMBL275117	0	1