Loeffler endocarditis

Summary

Loeffler endocarditis (MONDO:0019159) is a disease. A subtype of non-familial restrictive cardiomyopathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 27

Clinical features

Signs & symptoms

Clinical features (HPO)

27 HPO clinical features (Orphanet curated; top 27 by frequency):

HPO ID	Term	Frequency
HP:0001723	Restrictive cardiomyopathy	Very frequent (80-99%)
HP:0001880	Eosinophilia	Very frequent (80-99%)
HP:0001977	Abnormal thrombosis	Very frequent (80-99%)
HP:0031323	Myocardial eosinophilic infiltration	Very frequent (80-99%)
HP:0001635	Congestive heart failure	Frequent (30-79%)
HP:0001654	Abnormal heart valve morphology	Frequent (30-79%)
HP:0001712	Left ventricular hypertrophy	Frequent (30-79%)
HP:0001824	Weight loss	Frequent (30-79%)
HP:0001962	Palpitations	Frequent (30-79%)
HP:0002094	Dyspnea	Frequent (30-79%)
HP:0012378	Fatigue	Frequent (30-79%)
HP:0025168	Left ventricular diastolic dysfunction	Frequent (30-79%)
HP:0031331	Abnormal cardiomyocyte morphology	Frequent (30-79%)
HP:0100749	Chest pain	Frequent (30-79%)
HP:0001653	Mitral regurgitation	Occasional (5-29%)
HP:0001685	Myocardial fibrosis	Occasional (5-29%)
HP:0006685	Endocardial fibrosis	Occasional (5-29%)
HP:0010872	T-wave inversion	Occasional (5-29%)
HP:0011675	Arrhythmia	Occasional (5-29%)
HP:0011712	Right bundle branch block	Occasional (5-29%)
HP:0012735	Cough	Occasional (5-29%)
HP:0025523	Abnormal morphology of the chordae tendinae of the mitral valve	Occasional (5-29%)
HP:0031295	Left atrial enlargement	Occasional (5-29%)
HP:0031442	Abnormal tricuspid chordae tendinae morphology	Occasional (5-29%)
HP:0001650	Aortic valve stenosis	Very rare (<1-4%)
HP:0001659	Aortic regurgitation	Very rare (<1-4%)
HP:0001701	Pericarditis	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	Loeffler endocarditis
Mondo ID	MONDO:0019159
Orphanet	75566
DOID	DOID:396
ICD-11	1223390562
NCIT	C27044
SNOMED CT	449829009
UMLS	C0206143
MedGen	104788
GARD	0018929
MedDRA	10052841
Is cancer (heuristic)	no

Also known as: eosinophilic endocarditis · eosinophilic endomyocardial disease

Disease family

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › muscle tissue disorder › cardiomyopathy › intrinsic cardiomyopathy › restrictive cardiomyopathy › non-familial restrictive cardiomyopathy › Loeffler endocarditis

Related subtypes (6): cardiac sarcoidosis, hypereosinophilic syndrome, wild type ATTR amyloidosis, tropical endomyocardial fibrosis, AL amyloidosis, AA amyloidosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.