Logopenic progressive aphasia

Summary

Logopenic progressive aphasia (MONDO:0016644) is a disease and 15 clinical trials. A subtype of primary progressive aphasia — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 15

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	logopenic progressive aphasia
Mondo ID	MONDO:0016644
Orphanet	250831
DOID	DOID:0081389
SNOMED CT	716380002
UMLS	C4274665
MedGen	907332
GARD	0010791
Is cancer (heuristic)	no

Also known as: Logopenic primary progressive aphasia · Logopenic variant PPA · LPA

Disease family

This is a subtype of primary progressive aphasia. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › neurodegenerative disease › primary progressive aphasia › logopenic progressive aphasia

Related subtypes (1): GRN-related frontotemporal lobar degeneration with Tdp43 inclusions

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 15.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	13
PHASE2	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05386394	PHASE2	RECRUITING	Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
NCT06538311	EARLY_PHASE1	RECRUITING	Transcranial Magnetic Stimulation Treatment for Alzheimer’s Disease
NCT02740634	Not specified	ACTIVE_NOT_RECRUITING	Molecular and Structural Imaging in Alzheimer’s Disease: A Longitudinal Study
NCT03887481	Not specified	RECRUITING	Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
NCT04122001	Not specified	ACTIVE_NOT_RECRUITING	Effects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer’s Disease
NCT04680130	Not specified	ENROLLING_BY_INVITATION	Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders
NCT04881617	Not specified	ACTIVE_NOT_RECRUITING	Treatment for Speech and Language in Primary Progressive Aphasia
NCT06649084	Not specified	ENROLLING_BY_INVITATION	Primary Progressive Aphasia Multicomponent Language Treatment Study
NCT07219680	Not specified	RECRUITING	Intervention for Communication Quality of Life in Primary Progressive Aphasia
NCT07260253	Not specified	RECRUITING	Remotely-supervised Neuromodulation in PPA
NCT01095744	Not specified	COMPLETED	Influence of Age on Amyloid Load in Alzheimer’s Disease and in Atypical Focal Cortical Alzheimer’s Disease
NCT02289118	Not specified	COMPLETED	Tau Imaging in Young Onset Dementia
NCT03153371	Not specified	COMPLETED	Early-onset Alzheimer’s Disease Phenotypes: Neuropsychology and Neural Networks
NCT04193267	Not specified	UNKNOWN	Can Magnetic Brain Stimulation Improve Language Function in Primary Progressive Aphasia
NCT06181500	Not specified	COMPLETED	Home-Based Exercise in Primary Progressive Aphasia (HEPPA)