Lumbar spinal stenosis

Summary

Lumbar spinal stenosis (MONDO:0044753) is a disease and 202 clinical trials. Top therapeutic interventions include dexamethasone sodium phosphate, diphenhydramine, and methylprednisolone acetate. A subtype of spinal stenosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 202

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	lumbar spinal stenosis
Mondo ID	MONDO:0044753
NCIT	C177445
SNOMED CT	18347007
UMLS	C0158288
MedGen	488791
Anatomy (UBERON)	UBERON:0006074
Is cancer (heuristic)	no

Also known as: lumbar region of vertebral column spinal stenosis · lumbar spinal stenosis · spinal stenosis of lumbar region · spinal stenosis of lumbar region of vertebral column

Data availability: 1 HPO phenotype.

Disease family

This is a subtype of spinal stenosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › vertebral column disorder › spinal stenosis › lumbar spinal stenosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 202.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	174
PHASE4	16
PHASE3	4
PHASE2	4
EARLY_PHASE1	3
PHASE1/PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05029726	PHASE4	RECRUITING	Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery
NCT06157177	PHASE4	RECRUITING	Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions.
NCT00517751	PHASE4	TERMINATED	Condition of Approval Study
NCT00558129	PHASE4	WITHDRAWN	Effects of X-STOP® Versus Laminectomy Study
NCT00638443	PHASE4	COMPLETED	Lumbar Stenosis Outcomes Research (LUSTOR)
NCT00652093	PHASE4	TERMINATED	Lumbar Stenosis Outcomes Research II
NCT00956631	PHASE4	COMPLETED	MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study
NCT00995371	PHASE4	COMPLETED	Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis
NCT01057641	PHASE4	TERMINATED	Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant
NCT01082159	PHASE4	COMPLETED	MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study
NCT01934868	PHASE4	COMPLETED	Prolotherapy Versus Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg
NCT02063035	PHASE4	COMPLETED	Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery
NCT03245671	PHASE4	WITHDRAWN	Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal Stenosis
NCT03745040	PHASE4	SUSPENDED	Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion
NCT05345249	PHASE4	COMPLETED	Erector Spinae Plane Block as Pain Management After Lumbar Fusion Surgery
NCT05871073	PHASE4	COMPLETED	Dexamethasone as Adjuvant to Ropivacaine in Wound Infiltration for Postoperative Analgesia Following Spinal Surgery
NCT05058287	PHASE3	RECRUITING	Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression
NCT00405691	PHASE3	COMPLETED	Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis
NCT00418197	PHASE3	UNKNOWN	Total Facet Arthroplasty System®(TFAS®) Clinical Trial
NCT04341831	PHASE3	UNKNOWN	Does Teicoplanin Powder Use In Lumbar Instrumentation Surgery Reduce Surgical Site Infection
NCT04066296	PHASE2	RECRUITING	Outcomes for Lumbar Decompressions With Use of Liposomal Bupivicaine
NCT06907849	PHASE2	ENROLLING_BY_INVITATION	124I-Evuzamitide PET/CT Imaging In Patients With Lumbar Spinal Stenosis and Carpal Tunnel Syndrome
NCT06945926	PHASE2	NOT_YET_RECRUITING	The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery
NCT00527527	PHASE2	COMPLETED	Chiropractic Dosage for Lumbar Stenosis
NCT04537026	PHASE1/PHASE2	COMPLETED	Sterile Amniotic Fluid Filtrate Epidural Injection.
NCT04992572	EARLY_PHASE1	RECRUITING	Study Comparing Local/ MAC Anesthesia in Lumbar Decompression
NCT07281625	EARLY_PHASE1	RECRUITING	Decompressive Laminectomy Versus Laminectomy With Transpedicular Fixation in Lumbar Spinal Stenosis
NCT03088306	EARLY_PHASE1	COMPLETED	Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients
NCT02007083	Not specified	ACTIVE_NOT_RECRUITING	The NORDSTEN Studies/ The Spinal Stenosis Study
NCT03072927	Not specified	RECRUITING	MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
NCT03115983	Not specified	ACTIVE_NOT_RECRUITING	LimiFlex Clinical Trial for the Treatment of Degenerative Spondylolisthesis With Spinal Stenosis
NCT03570801	Not specified	ACTIVE_NOT_RECRUITING	SLIP II Registry: Spinal Laminectomy Versus Instrumented Pedicle Screw Fusion
NCT03853356	Not specified	ACTIVE_NOT_RECRUITING	Evidence For Fusion In Spine With Orthoss®
NCT03879447	Not specified	ACTIVE_NOT_RECRUITING	Effectiveness and Safety of Korean Medicine for Low Back Pain or Sciatica Due to Lumbar Stenosis/Spondylolisthesis
NCT04192591	Not specified	ACTIVE_NOT_RECRUITING	A 5-year Superion™ IDS Clinical Outcomes Post-Approval Evaluation (SCOPE)
NCT04273828	Not specified	RECRUITING	Impact of Muscle Degeneration in Chronic Low Back Pain
NCT04540068	Not specified	RECRUITING	Prediction of TEI Success in Sciatica
NCT04876612	Not specified	RECRUITING	Effect of Limaprost in Combination With Transforaminal Epidural Steroid Injection
NCT05273879	Not specified	RECRUITING	Necessity of Fusion Following Decompression Surgery in Patients With Single-level Lumbar Stenosis
NCT05504499	Not specified	RECRUITING	REFINE Study: A Study In a Novel Interspinous Fusion Device In Subjects With Low Back Pain

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DEXAMETHASONE SODIUM PHOSPHATE	4	2
DIPHENHYDRAMINE	4	1
METHYLPREDNISOLONE ACETATE	4	1
PREGABALIN	4	1
TRANEXAMIC ACID	4	1
ALANINE	3	1
TEICOPLANIN	3	1
LUFENURON	2	1
CHEMBL2105779	0	1
CHEMBL2367892	0	1
CHEMBL1200637	0	1
CHEMBL4743806	0	1
TEICOPLANIN A2-3	-1	1