Lymph node disorder

Summary

Lymph node disorder (MONDO:0004928) is a disease and 16 clinical trials. Top therapeutic interventions include indocyanine green acid form. A subtype of lymphatic system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 16

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	lymph node disorder
Mondo ID	MONDO:0004928
DOID	DOID:9942
NCIT	C35346
SNOMED CT	76616003
UMLS	C0272394
MedGen	78802
Anatomy (UBERON)	UBERON:0000029
Is cancer (heuristic)	no

Also known as: disease of lymph node · disease or disorder of lymph node · disorder of lymph node · lymph node disease · lymph node disease or disorder · lymph node disorder

Disease family

This is a subtype of lymphatic system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › immune system disorder › lymphoid system disorder › lymphatic system disorder › lymph node disorder

Related subtypes (13): lymphatic system cancer, bubonic plague, splenic disorder, histiocytosis, lymphocele, lymphangitis, lymphogranuloma venereum, lymphangiectasis, hemophagocytic syndrome, plastic bronchitis, lymphedema, lymphatic vessel neoplasm, pseudolymphoma

Subtypes (4): glandular tularemia, lymphadenitis, lymph node tuberculosis, lymph node neoplasm

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 16.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	14
PHASE3	1
PHASE1/PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00287196	PHASE3	COMPLETED	Immediate Radiotherapy or Observation After Surgery for Melanoma Involving Lymph Nodes
NCT03204994	PHASE1/PHASE2	TERMINATED	Fluorescence Targeted Pelvic Lymph Node Mapping
NCT04403867	Not specified	RECRUITING	The Role of Micrometastasis and Isolated Tumor Cells (ITCs) in Endometrial and Cervical Cancer. A Multicenter Study.
NCT06049758	Not specified	NOT_YET_RECRUITING	D2 Versus D3 Dissection in Laparoscopic Right Hemicolectomy
NCT06340620	Not specified	RECRUITING	EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope
NCT02998619	Not specified	COMPLETED	Radiotherapy of Pelvic Lymph Nodes in High Risk Prostate Cancer - A Retrospective Analysis
NCT03073096	Not specified	TERMINATED	LYMPHA: Eliminating the Burden of Lymphedema in Patients Requiring Nodal Dissection
NCT03132883	Not specified	COMPLETED	Evolution of Indications for Transbronchial Ganglionic Ultrasound
NCT03621852	Not specified	UNKNOWN	Prospective Evaluation of the Diagnostic Efficacy of a EUS Guided FNB Needle (AQUIRE®)
NCT03760094	Not specified	UNKNOWN	Role of Color Doppler Ultrasound in Lymphadenopathy
NCT03903471	Not specified	UNKNOWN	22G-ProCore vs 22G-Standard Needle in Diagnosis of Lymphadenopathy by EBUS-TBNA
NCT04328792	Not specified	UNKNOWN	Prediction Model of CP-EBUS in the Diagnosis of Lymph Nodes
NCT04456283	Not specified	UNKNOWN	Survival of Patients With a Reduction in the Number of Lymph Nodes in Rectal Cancer After Neoadjuvant Chemoradiotherapy
NCT04497714	Not specified	COMPLETED	Identifying Ultrasonic Diagnostic Characteristics of Cervical Lymphadenopathy: A Retrospective, Multicenter Study
NCT04735302	Not specified	COMPLETED	Radiographic Characteristics of Mediastinal and Hilar Lymph Nodes in Sarcoidosis
NCT06243965	Not specified	COMPLETED	Is Desmoplastic Stromal Reaction Useful to Modulate Lymph Node Dissection in Sporadic Medullary Thyroid Carcinoma?

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
INDOCYANINE GREEN ACID FORM	4	2