Magnesium deficiency
disease diseaseOn this page
Summary
Magnesium deficiency (MONDO:0006844) is a disease and 19 clinical trials. Top therapeutic interventions include cholecalciferol, magnesium oxide, and magnesium chloride. A subtype of nutritional deficiency disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 19
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | magnesium deficiency |
| Mondo ID | MONDO:0006844 |
| EFO | EFO:1001029 |
| MeSH | D008275 |
| ICD-10-CM | E61.2 |
| SNOMED CT | 238118002 |
| UMLS | C0024473 |
| MedGen | 44244 |
| MedDRA | 10025433 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of nutritional deficiency disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › nutritional disorder › nutritional deficiency disease › magnesium deficiency
Related subtypes (13): Keshan disease, acquired night blindness, iron deficiency anemia, protein-energy malnutrition, folic acid deficiency anemia, ariboflavinosis, choline deficiency disease, endemic goiter, potassium deficiency, pernicious anemia, Wernicke-Korsakoff syndrome, pellagra, vitamin deficiency disorder
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 19.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 14 |
| PHASE4 | 2 |
| PHASE3 | 2 |
| PHASE2/PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01593501 | PHASE4 | COMPLETED | How Does Magnesium Status Influence Calcium Homeostasis? |
| NCT05149820 | PHASE4 | UNKNOWN | Point of Care RandOmisation Systems for Performing Embedded Comparative Effectiveness Trials Of Routine Treatments |
| NCT02032186 | PHASE3 | COMPLETED | A Randomized Clinical Trial of Oral Magnesium Supplementation in Pregnancy |
| NCT03466528 | PHASE2/PHASE3 | COMPLETED | Alcohol: Thiamine and or Magnesium 1 |
| NCT03840226 | PHASE3 | UNKNOWN | The Impact of Magnesium on Exercise Tolerance, Quality of Life and Clinical Outcomes in Chronic Heart Failure Patients |
| NCT06979648 | Not specified | NOT_YET_RECRUITING | Effectiveness of Qualia Magnesium+® Supplementation on RBC Magnesium Levels |
| NCT07338565 | Not specified | RECRUITING | Magnesium in Gastrointestinal Disease |
| NCT02674789 | Not specified | UNKNOWN | Ionized Magnesium in Athletes |
| NCT02719925 | Not specified | COMPLETED | Mineral Water Rich in Magnesium and Perceived Stress in Healthy Consumers |
| NCT03134417 | Not specified | COMPLETED | Magnesium and Vitamin D Supplementation and Cardiometabolic Outcomes |
| NCT03353636 | Not specified | COMPLETED | Bioavailability of Magnesium Supplements |
| NCT03471481 | Not specified | TERMINATED | Magnesium as a Mediator of Bone and Vitamin D Metabolism in Patients on Antiepileptic Drug Therapy |
| NCT03554668 | Not specified | COMPLETED | Systemic Inflammatory Response: Thiamine and Magnesium Status (Sir TaM Study) |
| NCT04130620 | Not specified | COMPLETED | Validation of the Magnesium Muscle Stretch Test |
| NCT04216836 | Not specified | COMPLETED | One Week of Magnesium Supplementation Lowers IL-6, Perceived Pain and Increases Post Exercise Blood Glucose in Response to Downhill Running |
| NCT04942119 | Not specified | UNKNOWN | Impact of Long-term Serum Magnesium and Potassium Levels Optimization and Multifactorial Adherence Intervention on the Progression of Diabetic Kidney Disease. |
| NCT04972344 | Not specified | COMPLETED | Preoperative Ionized Magnesium Assessment |
| NCT05271838 | Not specified | UNKNOWN | Protein and Magnesium in Ulcerative Colitis |
| NCT05630339 | Not specified | COMPLETED | Magnesium and Vitamin D Combination for Post-COVID Syndrome |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CHOLECALCIFEROL | 4 | 3 |
| MAGNESIUM OXIDE | 4 | 2 |
| MAGNESIUM CHLORIDE | 4 | 1 |
| MAGNESIUM CITRATE | 4 | 1 |
| MAGNESIUM SULFATE | 4 | 1 |
| MAGNESIUM | 3 | 1 |
Related Atlas pages
- Drugs: Cholecalciferol, Magnesium Oxide, Magnesium, Magnesium, Magnesium