Malabsorption syndrome
disease diseaseOn this page
Also known as malabsorption
Summary
Malabsorption syndrome (MONDO:0020598) is a disease (an umbrella term covering 9 Mondo subtypes) and 30 clinical trials. Top therapeutic interventions include lidocaine and tannic acid. A subtype of intestinal disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Umbrella term: 9 Mondo subtypes
- Clinical trials: 30
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | malabsorption syndrome |
| Mondo ID | MONDO:0020598 |
| EFO | EFO:0009554 |
| MeSH | D008286 |
| NCIT | C3214 |
| SNOMED CT | 32230006 |
| UMLS | C0024523 |
| MedGen | 44256 |
| Is cancer (heuristic) | no |
Also known as: malabsorption · malabsorption syndrome
Disease family
This is a subtype of intestinal disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › malabsorption syndrome
Related subtypes (57): intestinal atresia, steatorrhea, angiodysplasia of intestine, endometriosis of intestine, hypertrophic pyloric stenosis, mucocele of appendix, gastroenteritis, diverticulitis, intestinal obstruction, postgastrectomy syndrome, chronic intestinal vascular insufficiency, bowel dysfunction, irritable bowel syndrome, Whipple disease, inflammatory bowel disease, intestinal polyp, necrotizing enterocolitis, intestinal perforation, neurogenic bowel, pneumatosis cystoides intestinalis, volvulus of midgut, abetalipoproteinemia, aplasia cutis congenita-intestinal lymphangiectasia syndrome, trichohepatoenteric syndrome, protein-losing enteropathy, chronic diarrhea with villous atrophy, Satoyoshi syndrome, glucose-galactose malabsorption, congenital diarrhea 7 with exudative enteropathy, chronic atrial and intestinal dysrhythmia, congenital enterocyte heparan sulfate deficiency, short bowel syndrome, intractable diarrhea-choanal atresia-eye anomalies syndrome, solitary rectal ulcer syndrome, NK-cell enteropathy, chronic intestinal failure, intestinal lymphangiectasia, refractory celiac disease, eosinophilic gastrointestinal disease, cryptogenic multifocal ulcerous stenosing enteritis, chronic enteropathy associated with SLCO2A1 gene, cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder, malakoplakia, ischemic bowel disorder, intestinal neoplasm, intestinal motility disease, 4-hydroxyphenylacetic aciduria, parasitic intestinal disorder, Aeromonas hydrophila intestinal disease, large intestine disorder, small intestine disorder, primary desmosis coli, isolated mesenteric vein thrombosis, collagenous sprue, visceral leiomyopathy, African degenerative, intestinal dysmotility syndrome, intestinal fistula
Subtypes (9): tropical sprue, intestinal disaccharidase deficiency, celiac disease, blind loop syndrome, hereditary folate malabsorption, lysine malabsorption syndrome, idiopathic malabsorption due to bile acid synthesis defects, autoimmune enteropathy, lactose intolerance
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated or in trials for this disease
1 approved drug — disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Status |
|---|---|
| Teduglutide | Approved (phase 4) |
Clinical trials & evidence
Clinical trials
Clinical trials: 30.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 24 |
| PHASE3 | 3 |
| PHASE2 | 2 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00521703 | PHASE3 | COMPLETED | Evaluation of Topical Lidocaine Spray as Adjuvant to Upper Gastrointestinal Endoscopy in Children |
| NCT00662675 | PHASE3 | COMPLETED | A Study of the Efficacy and Tolerability of Pancrelipase Microtablet (MT) Capsules for the Treatment of Cystic Fibrosis-dependent Exocrine Pancreatic Insufficiency |
| NCT02247102 | PHASE3 | UNKNOWN | Investigate the Breath Hydrogen Exhalation After a Test Meal Containing Isomaltulose or Sucrose in Infants |
| NCT06904872 | PHASE2 | RECRUITING | Safety and Efficacy of Crofelemer in Adult Patients With Short Bowel Syndrome and Intestinal Failure (SBS-IF) Without Colon-in-continuity (CIC) |
| NCT03644069 | PHASE2 | UNKNOWN | A Study of the Safety, Efficacy and Tolerability of Nexvax-2 in Patients With Celiac Disease (CeD) |
| NCT03543540 | PHASE1 | COMPLETED | Bioequivalence Study of Nexvax2 in Subjects With Celiac Disease |
| NCT03530852 | Not specified | RECRUITING | A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB |
| NCT05209568 | Not specified | RECRUITING | Immune Responses to Gluten |
| NCT05635747 | Not specified | ENROLLING_BY_INVITATION | A 90 Day Observational Study as an Extension to the Phase 3,Open Labeled Exploratory Study of RELiZORB |
| NCT06858631 | Not specified | ACTIVE_NOT_RECRUITING | IMPact of AerobiC Exercise in Addition to Nutritional Treatment on Quality of Life After Pancreatectomy |
| NCT06877923 | Not specified | RECRUITING | Elemental 028 Extra Case Studies |
| NCT07366151 | Not specified | NOT_YET_RECRUITING | Long-term Health Outcomes of Screen Detected and Potential Celiac Disease Patients |
| NCT00138879 | Not specified | COMPLETED | Citrulline: A Plasmatic Marker to Assess and Monitor Small Bowel Crohn’s Disease Patients |
| NCT00163813 | Not specified | UNKNOWN | The Early Nasojejunal Tube to Meet Energy Requirements in Intensive Care (ENTERIC) Study |
| NCT00456729 | Not specified | COMPLETED | Malabsorption as a Cause of Iron Treatment Failure in Infants |
| NCT00816842 | Not specified | COMPLETED | Plasma Citrulline Concentration in Tropical Enteropathy |
| NCT00872092 | Not specified | COMPLETED | Validation of Breath Tests in Diagnosing Small Bowel Bacterial Overgrowth |
| NCT01141998 | Not specified | COMPLETED | Vitamin D Substitution for Patients With Chronic Pancreatitis and Malabsorption |
| NCT01862510 | Not specified | COMPLETED | Detection of Celiac Disease in Patients With Hypothyroidism |
| NCT01900288 | Not specified | COMPLETED | Home Parenteral Nutrition (HPN) Families’ Mobile Distance Connections to Care Research |
| NCT02590120 | Not specified | COMPLETED | Enteral Nutrition and Amino Acid Absorption |
| NCT02750787 | Not specified | COMPLETED | Use of a Peptide-based Formula in an Adult Population |
| NCT02953223 | Not specified | COMPLETED | A Study to Monitor the Use of an Amino Acid-Based Infant Formula |
| NCT02987569 | Not specified | COMPLETED | Teen and Young Adult Connections for Support From Multidisciplinary Professionals & Peers |
| NCT03140371 | Not specified | COMPLETED | High Energy High Protein Peptide Feed Study |
| NCT03462979 | Not specified | SUSPENDED | Effects of Home Gluten Immunogenic Peptide Testing on Children With Celiac Disease |
| NCT03897517 | Not specified | UNKNOWN | Effect of Proprietary Botanical Blend on Glycemic Control and Post-prandial Carbohydrate Absorption |
| NCT04309149 | Not specified | COMPLETED | Market Research - Acceptability Study for a Range of MCT Products |
| NCT04309214 | Not specified | COMPLETED | Market Research - Acceptability Study for New MCT Fat Products |
| NCT04777682 | Not specified | UNKNOWN | Intestinal Ultrasound Versus Double Balloon Enteroscopy (DBE) in Diagnosis of Malabsorption Syndrome |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| LIDOCAINE | 4 | 1 |
| TANNIC ACID | 4 | 1 |
| CHEMBL3039201 | 0 | 1 |
| CHEMBL5193262 | 0 | 1 |
Related Atlas pages
- Drugs: Lidocaine, Tannic Acid