Male infertility due to acephalic spermatozoa
diseaseOn this page
Also known as Acephalic spermatozoa syndrome
Summary
Male infertility due to acephalic spermatozoa (MONDO:0035153) is a disease. A subtype of male infertility — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide) [Orphanet-validated]
- Phenotypes (HPO): 7
Clinical features
Signs & symptoms
Clinical features (HPO)
7 HPO clinical features (Orphanet curated; top 7 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0003251 | Male infertility | Very frequent (80-99%) |
| HP:0012869 | Acephalic spermatozoa | Very frequent (80-99%) |
| HP:0000798 | Oligozoospermia | Frequent (30-79%) |
| HP:0012207 | Reduced sperm motility | Frequent (30-79%) |
| HP:0012867 | Sperm mid-piece anomaly | Occasional (5-29%) |
| HP:0002916 | Abnormality of chromosome segregation | Excluded (0%) |
| HP:0008226 | Androgen insufficiency | Excluded (0%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | male infertility due to acephalic spermatozoa |
| Mondo ID | MONDO:0035153 |
| Orphanet | 529970 |
| DOID | DOID:0112311 |
| GARD | 0017971 |
| Is cancer (heuristic) | no |
Also known as: Acephalic spermatozoa syndrome
Disease family
This is a subtype of male infertility. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › reproductive system disorder › male reproductive system disorder › male infertility › male infertility due to acephalic spermatozoa
Related subtypes (7): infertility due to extratesticular cause, oligospermia, spermatogenic failure, partial chromosome Y deletion, male infertility with teratozoospermia due to single gene mutation, azoospermia, oligoasthenoteratozoospermia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.