Malignant breast phyllodes tumor

Summary

Malignant breast phyllodes tumor (MONDO:0002489) is a cancer and 6 clinical trials. A subtype of breast cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 6

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	malignant breast phyllodes tumor
Mondo ID	MONDO:0002489
EFO	EFO:0008545
DOID	DOID:3016
ICD-11	147026376
NCIT	C4504
SNOMED CT	254844000
UMLS	C0346154
MedGen	87543
GARD	0023148
Is cancer (heuristic)	yes

Also known as: breast malignant phyllodes tumour · breast phyllodes tumor, malignant · malignant breast phyllodes neoplasm · malignant breast phyllodes tumor · malignant cystosarcoma phyllodes of breast · malignant cystosarcoma phyllodes of the breast · malignant mammary phyllodes neoplasm · malignant mammary phyllodes tumor · malignant phyllodes breast neoplasm · malignant phyllodes neoplasm · malignant phyllodes neoplasm of breast · malignant phyllodes neoplasm of the breast · malignant phyllodes tumor (morphologic abnormality) · malignant phyllodes tumor of breast · malignant phyllodes tumor of the breast · malignant phyllodes tumour · malignant phyllodes tumour (morphologic abnormality) · malignant phyllodes tumour of breast · malignant phyllodes tumour of the breast · phyllodes breast neoplasm (+3 more)

Data availability: 3 cell lines.

Disease family

This is a subtype of breast cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › thoracic cancer › breast cancer › malignant breast phyllodes tumor

Related subtypes (5): breast sarcoma, malignant breast melanoma, breast lymphoma, breast carcinoma, salivary gland type cancer of the breast

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 6.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	5
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03635632	PHASE1	ACTIVE_NOT_RECRUITING	C7R-GD2.CART Cells for Patients With Relapsed or Refractory Neuroblastoma and Other GD2 Positive Cancers (GAIL-N)
NCT06286267	Not specified	RECRUITING	AI-Assisted System for Accurate Diagnosis and Prognosis of Breast Phyllodes Tumors
NCT03030677	Not specified	COMPLETED	Establishing Technique for PECS2 Catheter Insertion
NCT03868475	Not specified	WITHDRAWN	Comparing Vacuum-Assisted Percutaneous Excision to Open Surgical Excision for Borderline or High-Risk Breast Lesions
NCT04571307	Not specified	UNKNOWN	Cryotherapy in Breast B3 Lesions
NCT06780059	Not specified	COMPLETED	Effects of Radiotherapy in Borderline and Malignant Phyllodes Tumors After R0 Resection