Malignant neoplasm of thoracic esophagus
disease diseaseOn this page
Also known as cancer of thoracic part of esophaguscancer of thoracic part of oesophagusmalignant neoplasm of the thoracic esophagusmalignant neoplasm of the thoracic oesophagusmalignant neoplasm of thoracic part of esophagusmalignant neoplasm of thoracic part of oesophagusmalignant thoracic part of esophagus neoplasmmalignant thoracic part of oesophagus neoplasmthoracic part of esophagus cancerthoracic part of oesophagus cancer
Summary
Malignant neoplasm of thoracic esophagus (MONDO:0021325) is a cancer and 1 clinical trial. Top therapeutic interventions include carboplatin and ganetespib. A subtype of esophageal cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 1
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | malignant neoplasm of thoracic esophagus |
| Mondo ID | MONDO:0021325 |
| NCIT | C3532 |
| SNOMED CT | 187723009 |
| UMLS | C0153411 |
| MedGen | 102268 |
| GARD | 0027889 |
| Anatomy (UBERON) | UBERON:0035216 |
| Is cancer (heuristic) | yes |
Also known as: cancer of thoracic part of esophagus · cancer of thoracic part of oesophagus · malignant neoplasm of the thoracic esophagus · malignant neoplasm of the thoracic oesophagus · malignant neoplasm of thoracic part of esophagus · malignant neoplasm of thoracic part of oesophagus · malignant thoracic part of esophagus neoplasm · malignant thoracic part of oesophagus neoplasm · thoracic part of esophagus cancer · thoracic part of oesophagus cancer
Disease family
This is a subtype of esophageal cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › digestive system cancer › esophageal cancer › malignant neoplasm of thoracic esophagus
Related subtypes (6): esophagus lymphoma, esophageal melanoma, esophagus sarcoma, carcinoma of esophagus, malignant neoplasm of abdominal esophagus, malignant neoplasm of cervical esophagus
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 1.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02389751 | PHASE1 | COMPLETED | Ganetespib in Combination With Paclitaxel, Carboplatin, and Radiation Therapy in Treating Patients With Stage II-III Esophageal Cancer |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CARBOPLATIN | 4 | 1 |
| GANETESPIB | 3 | 1 |
Related Atlas pages
- Drugs: Carboplatin, Ganetespib